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find Author "杨芳" 7 results
  • Study on the intervention of platelet biological activity by ultrasound

    Platelets are non-nucleated blood effector cells, which plays an important role in coagulation, hemostasis, and thrombosis. However, platelets are extremely susceptible to activation by external stimuli, which in turn damages the platelet’s natural biological activity and affects its biological function. Platelet biological activity has become a hotspot in the field of vascular diseases. In this study, ultrasound parameters (ultrasound intensity and duration time) were used to intervene in the biological activity of platelets. The response of platelets to ultrasound energy was explored from the aspects of platelet morphology, aggregation ability and particle release (the expression of P-selectin and the number of particles). The results showed that the ultrasound intensity of 0.25 W/cm2 (1 MHz, 60 s) had no effect on the morphology, aggregation ability and particle release of platelets. When the ultrasonic intensity was increased to greater than 0.25 W/cm2, the generation of platelet pseudopods, morphological changes, increase of particle release, as well as effect on aggregation were observed. When the ultrasound duration time was 60 s (1 MHz, 0.25 W/cm2), it had no effect on the biological activity of platelets. However, when the ultrasound time was greater than 60 s, the morphology, aggregation ability and microparticles release would been induced with no effect on the secretion of CD62P and total protein components. Therefore, when the ultrasound parameters were 1 MHz and 0.25 W/cm2 with 60 s duration time, the ultrasound energy had no effect on the biological activity of platelets. The results in this study are of great significant for ultrasound energy intervention for the treatment of platelet-related diseases.

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  • 小儿静脉留置针的护理进展

    【摘要】小儿静脉留置针以操作简单、使用方便、套管柔软、套管在静脉内留置时间长且不宜穿破血管,可随时进行输液治疗,不仅有利于危重患儿的抢救和提高护理工作效率,还可以减轻患儿痛苦,已被广泛应用于临床。为了充分发挥留置针的临床应用效果,进一步提高护理质量,护理人员应重视留置针置管过程中每一环节的护理。置管前根据患儿的年龄及病情选择合适的留置针及穿刺部位,掌握正确的置管方法,妥善固定,置管后严密观察局部反应,做好穿刺部位局部护理,正确封管,同时加强患儿及家长的健康教育和心理护理,可有效预防并发症的发生,减轻患儿痛苦,促进患儿尽早康复。

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  • Comparison of Various Venae Profundae Catheterization

    目的:比较不同部位、不同方式深静脉置管的优缺点。方法:根据患者病情及能否配合操作,分别采用锁骨下静脉穿刺置管术、颈内静脉穿刺置管术、股静脉穿刺置管术并将三种术式的优缺点及所致的并发症进行比较。结果:276例深静脉置管术中(1) 经锁骨下置管者220例,占79.71%。其中术后感染2例,占0.91%;误入动脉2例,占0.91%;纵膈血肿1例,占0.45%;(2) 经颈内静脉置管者35例,占12.68%。其中术后感染3例,占1.40%;误入动脉者1例,占2.86%;气胸1例,占2.86%;术后导管脱落者1例,占2.86%;(3) 经股静脉置管者21例,占7.60%。其中术后感染5例,占23.8%;误入动脉者1例,占4.76%。结论:几种深静脉穿刺术中,尤以经锁骨下穿刺者并发症相对较少,是深静脉置管方式中的首选。

    Release date:2016-09-08 10:01 Export PDF Favorites Scan
  • Advancements in ophthalmological research on Waardenburg syndrome

    Waardenburg syndrome is a rare genetic disease of auditory pigmentation. The main symptom is sensorineural hearing loss. Pigment disorders and other developmental defects in skin, hair, iris, fundus and other parts are specifically divided into four different subtypes, each of which corresponds to different pathogenic genes, which encode transcription factors and signaling molecules that play a key role in the development process of neural crest cells into melanocytes. Because there are multiple subtypes of Waardenburg syndrome, different subtypes exhibit different symptoms, signs and ocular manifestations. Patients with Waardenburg syndrome are often first treated in ENT head and neck surgery due to hearing loss. Lack of theoretical knowledge related to Waardenburg syndrome by ophthalmologists may lead to misdiagnosis or missed diagnosis. Although there are currently limited treatments for the disease, with the continuous development of gene therapy and hearing management methods, the future treatment prospects will be broader.

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  • Effects of autologous platelet-rich gel on the treatment of refractory diabetic foot ulcer

    Objective To investigate the effects of autologous platelet-rich gel (APG) combined with intelligent trauma negative-pressure comprehensive therapeutic instrument on patients with refractory diabetic foot ulcer (DFU). Methods A total of 80 patients with refractory DFU treated in the hospital from January 2015 to January 2017 were divided into the trial group (n=40) and the control group (n=40) by the random number table method. The patients in the two groups were given routine treatment, and on the basis, the patients in the control group were treated with the intelligent trauma negative-pressure comprehensive therapeutic instrument while the ones in the trial group were treated with APG combined with intelligent trauma negative-pressure therapeutic instrument alternately. All patients were observed for 12 weeks. The cure rates, healing time and changes of wound volumes in the two groups before treatment and at 2, 4, 8, and 12 weeks after treatment were recorded. Results The total effective rate of treatment in the trial group was higher than that in the control group (87.5% vs. 67.5%, P<0.05). The wound volumes in the two groups at 4, 8 and 12 weeks after treatment were smaller than those before treatment and at 2 weeks after treatment (P<0.05). The wound volumes in the trial group at 4, 8 and 12 weeks after treatment were significantly smaller than those in the control group (P<0.05). The healing times of Wagner Ⅱ and Ⅲ DFU in the trial group were significantly shorter than those in the control group [(24.71±4.29)vs. (33.84±6.09) days, P<0.05; (33.04±5.97)vs. (45.29±7.05) days, P<0.05]. Conclusion Alternate treatment with APG combined with intelligent trauma negative-pressure comprehensive therapeutic instrument for refractory DFU can promote wound healing, shorten wound healing time, and improve the clinical efficacy.

    Release date:2018-11-22 04:28 Export PDF Favorites Scan
  • Research progress of foveal avascular zone in retinal vascular disease

    The fovea avascular area (FAZ) is an area of the retina surrounded by a continuous capillary plexus that does not have any capillary structure of its own. FAZ is an important region for the formation of fine vision function. The changes of its morphology and surrounding capillary density reflect the degree of macular ischemia, and are closely related to retinal vascular diseases such as diabetic retinopathy, retinal vein occlusion, Coats disease, idiopathic macular telangiectasia, and retinopathy of prematurity. Early observation of FAZ region changes in patients with retinal vascular disease by optical coherence tomography angiography (OCTA) can evaluate the severity and prognosis of the disease. However, the measurement error of FAZ-related data is still a problem that cannot be ignored. At present, OCTA devices of various manufacturers have different methods and algorithms for measuring and analyzing FAZ, which makes it impossible to compare the measured data between different devices. It is believed that with the continuous progress of OCTA related technology, more accurate data of FAZ regional changes can be obtained, which will bring more help to clinical work.

    Release date:2021-03-19 07:10 Export PDF Favorites Scan
  • Image Feature Extraction and Discriminant Analysis of Xinjiang Uygur Medicine Based on Color Histogram

    Image feature extraction is an important part of image processing and it is an important field of research and application of image processing technology. Uygur medicine is one of Chinese traditional medicine and researchers pay more attention to it. But large amounts of Uygur medicine data have not been fully utilized. In this study, we extracted the image color histogram feature of herbal and zooid medicine of Xinjiang Uygur. First, we did preprocessing, including image color enhancement, size normalizition and color space transformation. Then we extracted color histogram feature and analyzed them with statistical method. And finally, we evaluated the classification ability of features by Bayes discriminant analysis. Experimental results showed that high accuracy for Uygur medicine image classification was obtained by using color histogram feature. This study would have a certain help for the content-based medical image retrieval for Xinjiang Uygur medicine.

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