目的观察激光腔内闭合联合点式切除治疗下肢静脉曲张的疗效。方法回顾性分析我科2007年5月至2011年1月期间采用激光腔内闭合联合点式切除治疗310例下肢静脉曲张患者的临床资料，其中男121例，女189例，共406条肢体; 平均年龄52.6岁。结果所有患者术后临床症状得到改善，术后第3天查彩超显示所有大隐静脉主干完全闭合。36例合并皮肤溃疡患者中25例术后经换药后溃疡面明显缩小，11例术后3个月溃疡面愈合。术后有110例出现不同程度患肢皮下瘀斑，15例出现大隐静脉行程的皮下血肿，未予特殊处理，术后2~3周后均自行好转。术后出现小腿中下段内侧皮肤麻木及感觉障碍118例，术后3个月均有不同程度好转。所有患者切口一期愈合，无切口感染，未出现皮肤烧灼伤及术后下肢深静脉血栓形成。平均住院时间6.3 d。结论激光腔内闭合联合点式切除是治疗下肢静脉曲张的微创、安全及有效的方法。
Objective To explore the methods of early diagnosis of arteriosclerosis obliterans of lower extremity (ASOLE). Methods The related literatures on ASOLE detection means adopted clinically were reviewed, and their advantages and disadvantages were compared.Results Asymptomatic ASOLE could be discovered by determination of ankle brachial index (ABI) and toe brachial index (TBI), which was a good index for arterial function assessment of lower extremity. Pulse wave velocity (PWV) was more vulnerable and less sensitive than ABI, and therefore more suitable for screening of a large sample. ASI was an index to assess arterial structure and function, and it had a good correlation with PWV. Flow-mediated dilation (FMD) was a measurement evaluating the function of endothelial cell; Pulse wave measurement was simple, sensitive, and its result was reliable. Color Doppler ultrasonography could localizate the lesion and determine the degree of stenosis at the same time. Multiple-slice CT angiography (MSCTA) was more accurate than color Doppler ultrasonography, but its inherent shortcomings, such as nephrotoxicity of contrast agent, was still need to be resolved. 3D-contrast enhancement magnetic resonance angiography (CEMRA) had little nephrotoxicity, but a combination of other imaging methods was necessary. Microcirculation detections required high consistency of the measurement environment, but they were simple, sensitive and noninvasive, and therefore could be used for screening of ASO. Conclusion Publicity and education of highrisk groups, and reasonable selection of all kinds of detection means, are helpful to improve the early diagnosis of ASOLE.