Objective To compare the clinical efficacy and safety of thrombolysis with anticoagulation therapy for patients with acute sub-massive pulmonary thromboembolism. Methods The clinical data of 84 patients with acute sub-massive pulmonary thromboembolism were analyzed retrospectively, mainly focusing on the in-hospital efficacy and safety of thrombolysis and/ or anticoagulation. The efficacy was evaluated based on 6 grades: cured, markedly improved, improved, not changed, deteriorated and died. Results Among the 84 patients,49 patients received thrombolysis and sequential anticoagulation therapy( thrombolysis group) , 35 patients received anticoagulation therapy alone( anticoagulation group) . As compared with the anticoagulation group, the thrombolysis group had higher effective rate( defined as patients who were cured, markedly improved or improved, 81. 6% versus 54. 3%, P = 0. 007) , lower critical event occurrence ( defined as clinical condition deteriorated or died, 2. 0% versus 14. 3% , P = 0. 032) . There was no significant difference in bleeding rates between the two groups ( thrombolysis group 20. 4% versus anticoagulation group 14. 3% , P gt; 0. 05) . No major bleeding or intracranial hemorrhage occurred in any of the patients. Conclusions Thrombolysis therapy may be more effective than anticoagulation therapy alone in patients with acute sub-massive pulmonary thromboembolism, and thus warrants further prospective randomized control study in large population.
目的 了解住院患者病死率以及死亡病例的年龄、性别及主要死因的分布状况，为疾病预防治疗提供科学依据。 方法 对重庆医科大学附属第二医院2007年1月－2011年12月3 030例住院死亡患者进行统计分析，根据国际疾病分类第10版（ICD-10）进行疾病分类，所有资料经SPSS 13.0软件进行统计分析。 结果 该院近5年共有出院患者173 411例，死亡3 030例，病死率1.75%。各年龄段男性患者病死率均高于女性。各年度、不同性别前3位死因均依次为：肿瘤、循环系统疾病、呼吸系统疾病。 结论 慢性非传染性疾病是住院患者的主要死亡原因。提高医疗技术水平、普及群众的预防保健知识、大力开展健康体检是降低病死率的主要措施。