west china medical publishers
Keyword
  • Title
  • Author
  • Keyword
  • Abstract
Advance search
Advance search

Search

find Keyword "氧化酶增殖因子活化受体" 1 results
  • Research on mRNA Expression and Clinical Significance of Peroxisome Proliferator-activated Receptorγ and Vascular Endothelial Growth Factor C in Gastric Cancer Patients

    【摘要】 目的 研究过氧化酶增殖因子活化受体γ(peroxisome proliferator-activated receptor gamma, PPARγ)和血管内皮生长因子C(vascular endothelial growth factor C, VEGF-C)在胃癌组织中表达的相关性,分析其表达与临床病理因素之间的关系。 方法 2005年3月-2009年3月间采用逆转录-聚合酶链反应方法检测36例胃癌手术标本中PPARγ和VEGF-C mRNA的表达,同时选取相同患者的胃正常组织作为对照。 结果 PPARγ mRNA在胃癌中的表达量高于癌旁正常组织,两者的差异有统计学意义(P=0.007);VEGF-C在胃癌中的表达量高于癌旁正常组织,两者的差异有统计学意义(P=0.004);PPARγ的表达与VEGF-C表达无关联性(r=0.135,P=0.414);PPARγ表达与胃癌组织中浸润程度有关(χ2=4.620,P=0.032)、淋巴结转移有关(χ2=15.753,P=0.000)和临床病理分期有关(χ2=4.610,P=0.032);VEGF-C表达与胃癌组织中淋巴结转移有关(χ2=4.729,P=0.030)、远处转移有关(χ2=4.064,P=0.044)和临床病理分期有关(χ2=6.300,P=0.012)。 结论 PPARγ和VEGF-C可能在胃癌新生淋巴管形成中起重要作用,两者的表达水平与胃癌患者的病情判断及预后评价密切相关。【Abstract】 Objective To investigate the significance of expressions of peroxisome proliferator-activated receptor gamma (PPARγ) and vascular endothelial growth factor C (VEGF-C) in gastric carcinoma as well as their correlation, and to study the relationship between the expressions and clinicopathologic characteristics of gastric carcinoma.  Methods Thirty-six pairs of normal mucosa and cancer specimens were obtained from patients who had undergone gastric operation for primary gastric carcinoma and subjected to reverse transcription-ploymerase chain reaction (RT-PCR) for PPARγ and VEGF-C mRNA detection. Results The positive rate and level of PPARγ mRNA expression were higher in gastric cancer tissues than those in normal gastric mucosa (P=0.007). The positive rate and level of VEGF-C mRNA expression were also higher in gastric cancer tissues than those in normal gastric mucosa (P=0.004). Simultaneously, the expression of PPARγ was not correlated with that of VEGF-C (r=0.135, P=0.414), while the highly productions of PPARγ and VEGF-C in gastric carcinomas were both associated with the lymph node metastasis and the clinical stage (Plt;0.05). Conclusion PPARγ and VEGF-C may play an important role in the lymphangio-genesis of gastric cancer, and united detection of PPARγ and VEGF-C expressions may be correlated with making diagnosis, evaluating prognosis in patients with gastric cancer at the same time.

    Release date:2016-09-08 09:26 Export PDF Favorites Scan
1 pages Previous 1 Next

Format

Content