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find Keyword "烧伤" 123 results
  • Topical Phenytoin for Wound Healing: A Systematic Review

    Objective To explore the effectiveness and safety of topical phenytoin for wound healing. Methods We searched MEDLINE (1966 to Oct. 2002), EMBASE (1984 to 2002), The Cochrane Library (Issue 4, 2002), Biological Abstracts (1993 to 1996), Cancerlit (1997 to Sept. 2002), Life Science Collection (1982 to Mar. 1995), International Pharmaceutical Abstracts (1970 to 2002), and CBMdisc (1978 to Jan. 2003). Controlled trials on topical phenytoin for wound healing were identified. The methodological quality of included studies was assessed, and a descriptive analysis was performed. Results Nine studies (507 cases) including 1 randomized controlled trials (RCT) and 8 non-randomized controlled trials were included. These studies were of poor methodological quality. Because there were a variety of etiology of ulcers, differnet interventions in control groups, and different outcome measures, for which meta-analysis was difficult to perform, a descriptive analysis of the results was presented. Most studies showed that topical phenytoin had better effects on improving healthy granulation appearance, increasing complete recovery rate, reducing time for complete recovery, and positive cases of bacterial culture than those of control groups. Mild side effects were observed in only one study.Conclusions The reviewers think that the inclusion studies less rigorous than randomized controlled trials could result in misleading findings.Some well designed randomized controlled trials of topical phenytoin for wound healing are warranted.

    Release date:2016-08-25 03:33 Export PDF Favorites Scan
  • 湿润烧伤膏外涂治疗外周静脉留置针引发静脉炎的效果观察

    【摘要】 目的 总结湿润烧伤膏外涂治疗外周静脉留置针引发静脉炎的临床疗效。 方法 2007年9月-2008年3月,将62例使用外周静脉留置针引发静脉炎的患者按随机数字表法分为治疗组与对照组,每组各31例。治疗组患者使用湿润烧伤膏外涂治疗,对照组患者使用硫酸镁溶液局部湿敷常规治疗,观察两组患者穿刺点局部皮肤改善情况,并进行疼痛程度比较。 结果 治疗3 d后,局部皮肤改善与疼痛程度比较,治疗组均优于对照组,差异有统计学意义(Plt;0.05)。 结论 湿润烧伤膏外涂治疗外周静脉留置针引发静脉炎的疗效较好。

    Release date:2016-08-26 02:21 Export PDF Favorites Scan
  • 16例大面积Ⅲ度烧伤患者削痂术后延期自体植皮体会

    目的:观察延期断层浅筋膜创面(脂肪层)皮肤移植术治疗大面积Ⅲ度烧伤的临床效果。方法: 对16例大面积深度烧伤创面行早期(1~3 d)削痂术, 滚轴刀削除创面坏死组织至健康的浅筋膜界面, 行异体(种)皮移植过渡,以后根据异体(种)皮排异脱落、移植床血运重建和自体供皮情况,有计划的更植自体皮。观察患者总体治愈情况、创面愈合效果及创面愈合后的外观及功能情况。结果:本组患者共16例,无一例出现死亡,治愈率为100%。于术后2~3周创面愈合,多数瘢痕较轻,外形饱满,功能满意。功能部位植入大张皮片有3例出现局灶性坏死,通过换药愈合创面。少部分小皮片坏死,皮片间的肉芽组织过度生长,通过刮除高出的肉芽组织,并行换药治疗,创面愈合。随访16例功能部位植皮患者中,13例其皮肤外观、弹性及功能恢复良好,3例有轻、中度的功能障碍。结论:大面积Ⅲ度烧伤采用延期断层浅筋膜创面皮肤移植术,既可有效预防或减少并发症的发生,提高治愈率,又可减轻瘢痕形成,且功能部位早期得以良好修复,从而提高创面愈合质量。

    Release date:2016-08-26 02:21 Export PDF Favorites Scan
  • Clinical Analysis of Burn due to Epilepsy Attack

    目的:探讨癫痫发作致烧伤的临床特点及防治措施。方法:在系统抗癫痫的前提下,在抗休克、预防感染、营养支持等全身治疗同时,积极采用手术方法及早修复创面,结合良好的心理调试及护理。结果:该组43例患者除3例未完成治疗外,其余40例均痊愈出院,住院时间10~42天,住院期间出现癫痫再发作1例,经调整用药后控制,均无并发症发生。结论:采取系统的抗癫痫药物治疗与早期积极进行烧伤创面手术,全身和心理治疗并重的综合治疗方法,可使创面及早痊愈,明显降低癫痫再发作,是治疗癫痫合并烧伤的有效方法。

    Release date:2016-08-26 03:57 Export PDF Favorites Scan
  • 儿童食管腐蚀伤的外科治疗

    目的 探讨儿童食管腐蚀伤后瘢痕狭窄的预防和治疗措施. 方法 1988年5月~2000年5月收治食管腐蚀伤儿童32例,早期采用食管扩张3例,食管腔内置管8例;后期采用结肠代食管14例,胃代食管5例,颈阔肌皮瓣修复2例. 结果 全组手术治愈31例,死亡1例;术后发生并发症9例,其中吻合口瘘6例,吻合口狭窄2例,颈部瘘1例,均治愈.28例随访1~12年,均恢复进普通饮食;3例失访. 结论 早期食管腔内置管对预防食管腐蚀伤后瘢痕狭窄有明显疗效,结肠代食管术是后期食管重建的主要手段,主动脉弓以下瘢痕食管可切除用胃重建,颈阔肌皮瓣修复术是治疗颈部局限性食管狭窄的理想方法.

    Release date:2016-08-30 06:31 Export PDF Favorites Scan
  • RESEARCH PROGRESS OF MESENCHYMAL STEM CELLS IN BURN WOUND REPAIR

    Objective To review the research progress of mesenchymal stem cells (MSCs) in burn wound repair. Methods The recent literature about MSCs involved in burn wound repair and mechanism was extensively reviewed and analyzed. Results MSCs have the capacity of self-renew, rapid proliferation, differentiation and paracrine, and promote burn wound repair through differentiating into a series of skin wound cells and regulating wound microenvironment. Conclusion MSCs have great potentials in the burn field. However, the cell survival and outcome are also facing challenges from poor microenvironment of the burn wound.

    Release date:2016-08-31 04:07 Export PDF Favorites Scan
  • EFFECT OF SERUM FROM SEVERE BURN PATIENTS ON BIOLOGY CHARACTERISTICS OF HUMAN UMBILICAL CORD MESENCHYMAL STEM CELLS

    Objective To investigate the effect of the serum from severe burn patients on the biology characteristics of human umbilical cord mesenchymal stem cells (hUCMSCs) in vitro, so as to explore the feasibility of hUCMSCs transplantation for treating severe burn. Methods The 3rd passage of hUCMSCs were randomly divided into 3 groups: 10% fetal bovine serum group (group A), 10% normal serum group (group B), and 10% burn serum group (group C). At 24 hours, 72 hours, and 6 days after culture, the cell morphology and density were observed by inverted microscope; the cell proliferation was assessed by MTT; after 6 days of culture, the cell cycle by propidium iodide staining and flow cytometry, the apoptosis by acridine orange/ethidium bromide staining, and the cell senescence by β-galactosidase staining; the levels of tumor necrosis factor α (TNF-α), interleukin 1 (IL-1), platelet-derived growth factor (PDGF), and insulin-like growth factor 1 (IGF-1) in serum were detected by a double-antibody sandwich ELISA kit. Results hUCMSCs were long spindle/polygon in 3 groups. The cell fusion of group C was obviously faster than that in group A and group B. The cell proliferation curves showed that the velocity and number of cell proliferation in group C were significantly higher than those in group A and group B at 2-6 days after culture (P lt; 0.05). The rates of proliferation period (S) of hUCMSCs were 9.21% ± 1.02%, 11.79% ± 1.87%, and 20.54% ± 2.03%, respectively in groups A, B, and C at 6 days, and group C was significantly higher than that of group A and group B (P lt; 0.05). The hUCMSCs showed normal morphology and structure in 3 groups, and no apoptosis cells was observed. The positive cells percentage of group C (2.6% ± 0.1%) was significantly lower than that of group A (4.8% ± 0.2%) and group B (3.8% ± 0.4%) (P lt; 0.05). The levels of TNF-α, IL-1, PDGF, and IGF-1 in group C were significantly higher than those in group B (P lt; 0.05). Conclusion The higher levels of cytokines in serum from the severe burn patients can significantly stimulate hUCMSCs proliferation, prevent cells apoptosis, and reduce cells senescence. Therefore, it is feasible to use hUCMSCs transplantation for treating severe burn patients.

    Release date:2016-08-31 04:07 Export PDF Favorites Scan
  • 腕部高压电烧伤腹部皮瓣断蒂后手血运障碍二例

    Release date:2016-08-31 04:12 Export PDF Favorites Scan
  • EFFECTIVENESS EVALUATION OF COMPOSITE SKIN GRAFTS IN REPAIRING DEEP BURN WOUNDS INFUNCTIONAL REGIONS

    【Abstract】 Objective To evaluate the long-term effectiveness of composite grafts of acellular dermal matrix (ADM)and autologous spl it-thickness skin in repairing deep burn wounds. Methods Between June 2002 and December 2008, 30 patients (42 wound) were treated. There were 25 males and 5 females, aged 3-52 years with a median age of 31 years. Of them, 24 burned patients had 35 wounds, including 23 deep second degree and 12 third degree wounds with a mean disease duration of 24 days (range, 3-45 days); 6 patients with hyperplastic scar had 7 wounds with a mean disease duration of 16 days (range, 9-21 days). The wound locations were neck (2 wound), hand (4 wounds), forearm and elbow (8 wounds), shoulder (3 wounds), poples (6 wounds), laps (4 wounds), ankle and legs (15 wounds), and the area of wounds ranged from 10 cm × 10 cm to 30 cm × 20 cm. After thorough debridement, tangential excision, and scar excision, ADM and autologous spl it-thickness skin graft were used to repair the wounds by one-step method. Results After operation, composite skin graft survived completely in 39 wounds of 27 patients, with a survival rate of 92.9%; partial necrosis occurred in 3 wounds of 3 patients (7.1%), and healed after dressing change and secondary skin graft. The patients were followed up 30-34 months (mean, 32 months) postoperatively. The appearance of the composite grafts were smooth and soft with good elasticity and low pigmentation. The activity and function of limbs recovered well. No scar hyperplasia was observed at the donor sites. Conclusion It can achieve good outcomes in appearance and function to use ADM and autologous spl it-thickness skin graft for repairing deep burn wounds in functional regions.

    Release date:2016-08-31 04:22 Export PDF Favorites Scan
  • EFFECT OF EARLY DERMATOPLASTIC REPAIR ON TESTICULAR Survivin PROTEIN EXPRESSION IN JUVENILE PIGS WITH ENTIRE THIRD DEGREE BURN WOUND OF SCROTUM

    【Abstract】 Objective To explore the effect of early scrotal dermatoplasty on spermatogenic functional rehabilitation of testis in juvenile pigs with third degree burn wound of the scrotum. Methods Thirty healthy male Guizhou miniature pigs (weighing 10-15 kg, 2-month-old) were divided into 3 groups: control group (group A, n=10), natural healing group (group B, n=10), and dermatoplasty group (group C, n=10). In group A, the pig was not given any treatment; after third degree burn model of the scrotum was prepared, wounds were not treated in group B and the burn skin was excised and whole hypogastric pachydermia was used for dermatoplasty in group C. At 3 months and 1 year after model preparation, bilateral testis were collected from 5 pigs, respectively. HE staining was performed to observe the effects of different repair method on the morphology of spermatogenic cells and immunohistochemical staining was used to detect Survivin protein expression. Results All pigs survived to the end of the experiment and the wound healed successfully. Histological observation showed that spermatogenic cells had normal shape at all stages and mature sperms were seen in lumens in group A; the thickness of seminiferous epithelium was thinner, having one layer or two layers of spermatogenic cells in group B; the spermatogenic cells in group C were slightly more than that in group B with some spermatids; and in groups B and C, the spermatogenic cells at 1 year were more than that at 3 months. Immunohistochemistry staining showed that the Survivin protein expression in groups B and C was less than in group A, and group B was less than group C, showing significant differences at 3 months and 1 year (P lt; 0.05), but no significant difference between 3 months and 1 year in the same group (P gt; 0.05). Conclusion Dermatoplasty has inhibitory effect on spermatogenic functional rehabilitation of testis. Dermatoplasty can decrease spermatogenic cells and reduce Survivin protein expression, but some spermatids still survive in seminiferous tubule.

    Release date:2016-08-31 04:22 Export PDF Favorites Scan
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