west china medical publishers
Author
  • Title
  • Author
  • Keyword
  • Abstract
Advance search
Advance search

Search

find Author "王代科" 17 results
  • 胃十二指肠溃疡手术方式的选择

    Release date:2016-08-29 03:44 Export PDF Favorites Scan
  • 良性小肠疾病并大出血的诊断与治疗

    Release date:2016-08-29 03:44 Export PDF Favorites Scan
  • 临床病例讨论第3例——上腹隐痛2年加重2周

    Release date:2016-08-29 03:44 Export PDF Favorites Scan
  • 直肠癌保肛手术的现代观念

    Release date:2016-08-29 03:24 Export PDF Favorites Scan
  • 胃大部切除术后再手术127例分析

    Release date:2016-08-29 09:16 Export PDF Favorites Scan
  • GROSS AND HISTOLOGICAL OBSERVATIONS OF DOG’S STOMACH AFTER HIGHLY SELECTIVE VAGOTOMY AND MUCOSAL ANTRECTOMY

    Six dogs underwent high selective vagotomy and mucosal antrectomy (HSV+MA). The gross and histological change of dog’s stomach were observed at 4-6 months after operation. It was found that the reconstructed antrum healed well and there was no stasis and distension in the stomach .The appearance of the nerves in muscular layer of the antrum was normal. No serious gastritis and mucosal atrophy was observed. These results indicat that HSV+MA is a reasonable procedure for the treatment of duodenal ulcer.

    Release date:2016-08-29 03:44 Export PDF Favorites Scan
  • THE EARLY AND LATE CLINIC INVESTIGATION AFTER HIGH SELECTIVE VAGOTOMY AND MUCOSAL ANTRECTOMY FOR DUODENAL ULCER

    Objective To study the earlier and later clinic results of 64 chronic duodenal ulcer patients treated with high selective vagotomy and mucosal antrectomy (HSV+MA). Methods The clinic results of the patients and the changes of gastrin, motilin and somatostatin in the blood were prospectively investigated. Results Fifty nine (92.2%) patients after 3-6 months of follow-up and 26 (92.9%) patients after 5-8 years of follow-up achieved Visick grates Ⅰ-Ⅱ. No patients died. Gastric acid secretion and infection rate of helicobacter pylori in antral mucosa were significantly reduced after operation. No significant difference was showed in bile acids and total bacterial counts of gastric juice before and after operation. No ulcer recurrence was found by barium meal and endoscopy. There was no significant difference in serum gastrin and plasma motilin before and after operation. The level of somatostatin in the blood of patients after 5-8 years of follow-up was decreased. Conclusion HSV+MA is the better operative treatment for duodenal ulcer, since it can not only effectively and lastingly decrease acid secretion and rates of ulcer recurrence, but also preserve the function of the antrum and pylorus and keep the gastric milieu interne relatively stable.

    Release date:2016-09-08 01:59 Export PDF Favorites Scan
  • 早期直肠癌经骶尾局部切除12例分析

    目的总结经骶尾行直肠癌局部切除术治疗12例早期直肠癌的临床经验。方法1993年6月至2002年6月对其中12例早期直肠癌患者行经骶尾局部切除术并分析其治疗效果。结果该组病例术后平均住院14.6 d,其中2例术后发生切口感染,经治疗后愈合。术后随访2~110个月,平均38.2个月,局部复发2例,死亡1例。结论经骶尾局部切除术或局部切除术辅助放疗、化疗,适用于恶性程度较低的早期直肠癌患者。

    Release date:2016-08-28 04:43 Export PDF Favorites Scan
  • EFFECTS AND CLINICAL SIGNIFICANCE OF VINCRISTINE IN GASTRIN-STIMULATING CELL PROLIFERATION ON HUMAN COLONIC CANCER CELL LINE SW480

    Objective To investigate the mechanism and clinical significance of vincristine (VCR) inhibiting gastrinproliferation effects on human colon cell line SW480. Methods Effects of VCR on the viable cell count (A value), myoinositol triphosphate (IP3, CPM value), 〔Ca2+〕i and protein kinase C (PKC) activity of human colon cell line SW480 were evaluated in vitro by MTT assay,3Hmyoinositol incorporation, fluorescence measurements and γ-32P-ATP incorporation.Results A value of VCR+PG group was lower than that of PG or control group (P<0.01 vs control, P<0.01 vs PG). The concentration of IP3 or 〔Ca2+〕i in VCR+PG group was lower than that in PG group (P<0.01 vs PG); and the PKC activity of membrane was lower than that in PG group (P<0.05 vs PG, P>0.05 vs control). Conclusion Effects of vincristine may be through the phosphoinositide signaling pathway on gastrinstimulating cell proliferation in human colon cell line SW480. It has provided an experimental evidence for antisignaling therapy for patients with colon cancer.

    Release date:2016-09-08 01:59 Export PDF Favorites Scan
  • EFFECT OF PERITONEAL PERFUSION WITH HYPERTHERMIA, HYPER-OSMOLAR SOLUTIONS AND ANTINEOPLASTIC DRUG ON NORMAL TISSUE IN NUDE MICE

    To observe the pathologic changes of normal tissue in nude mice after peritoneal perfusion with hyperthermia, hyper-osmolar solution and mitomycin C (MMC). Fifty BALB/c nunu mices (7-10 weeks old) bearing HT-2 lines were chosen for the study, and were randomly divided into five groups: isotonic solution (control group), hyperosmolar solution (HOS group), HOS plus MMC group, hyperthermia (HT group) and HOS plus HT plus MMC group. After continuous hyperthermic peritoneal perfusion (42℃/30min) with 7.5% NaCl and 5μg/ml MMC, the liver, spleen, small intestine and kidney were examined by light microscopy. Results: ①In HOS and HOS plus MMC groups, no changes of liver, spleen and kidney were found. ②In HT and HOS plus HT plus MMC groups, slight degeneration of liver, hyperemia of spleen, swelling of kidney tubule cells and small intestine were found. ③In HOS plus HT plus MMC group, partial loss of small intestinal villi were also observed. Conclusioin: After continuous hyperthermic perfusion conbined with hyper-osmolar solutions and mitomycin C, a slight injury was showed in normal tissue of nude mice.

    Release date:2016-08-29 09:18 Export PDF Favorites Scan
2 pages Previous 1 2 Next

Format

Content