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find Author "王红" 14 results
  • Th17细胞在葡萄膜炎中的作用

    Th17细胞是新近发现的CD4+辅助性T细胞亚群。Th17细胞分泌以白细胞介素(IL)-17为主的致炎因子,导致炎症产生和升级,在介导多种炎症性自身免疫反应中发挥关键作用;在葡萄膜炎的发病过程中也占有重要地位。有关Th17细胞在葡萄膜炎中的作用机制和信号传导通路已成为免疫学研究的热点,随着Th17细胞的诱导分化、生物效应及其与葡萄膜炎致病关系研究的不断深入,有希望为葡萄膜炎的防治对策开辟新的研究方向和思路。

    Release date:2016-09-02 05:41 Export PDF Favorites Scan
  • 朗格汉斯细胞组织细胞增生症漏诊一例

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  • Current research status of negative immune checkpoint factors in autoimmune eye diseases

    Autoimmune ocular diseases are a type of inflammatory eye condition characterized by the involvement of the immune response. This includes various types disease such as autoimmune uveitis, thyroid-associated eye disease, and primary Sjögren's syndrome. In recent years, breakthroughs have been achieved in inducing transplant tolerance, understanding tumor immune evasion, and preventing autoimmune diseases using immune checkpoint molecules. Negative immune checkpoints effectively control disease progression by inhibiting T cell proliferation, reducing inflammatory cytokine levels, and ultimately regulating autoimmune balance. Therefore, the negative immune checkpoint molecules are expected to be used as a new therapeutic target in the future, and the combination therapy through the combination of negative immune checkpoint drugs is expected to become an important direction to improve the efficacy of the treatment of autoimmune diseases.

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  • 碱性成纤维细胞生长因子对视网膜缺血再灌注损伤中蛋白激酶C表达、Ca2+ 含量变化的影响

    Release date:2016-09-02 06:00 Export PDF Favorites Scan
  • 糖尿病患者烧伤创面的治疗

    【摘要】 目的 总结糖尿病患者烧伤后的创面诊治措施。 方法 回顾总结2007年10月-2010年5月30例糖尿病患者发生烧伤后,其治疗中就严格饮食控制、调节血糖、防治感染及处理创面等综合治疗的手段与方法。 结果 30例患者均未出现糖尿病急性并发症且烧伤创面愈合。 结论 加强血糖控制,积极创面处理,应用抗生素、防治多种并发症,是治疗糖尿病烧伤的关键。

    Release date:2016-09-08 09:27 Export PDF Favorites Scan
  • Related Factors for Acute Altitude Sickness in Tourists and the Nursing Intervention

    ObjectiveTo discuss the treatment and nursing care for Daocheng tourists with acute altitude sickness, and analyze its related factors. MethodsFrom April to September 2012, 236 Daocheng tourists with acute altitude sickness were given drugs in time, and underwent oxygen inspiration. On the basis of observing the disease, nurses also provided care and health education to the patients. ResultsBy guiding patients' psychology, diet, oxygen uptake, medication and health related education, we cured 234 patients, and the rest 2 with high altitude cerebral edema were cured after being transferred to low-lying areas. ConclusionTourists from low-lying areas are vulnerable to altitude sickness when touring high lands. Preventive medicine before entering highland areas, more rest and less exercise are important factors to prevent the occurrence of altitude sickness. Health education from nursing care providers can effectively guarantee the safety of tourists entering plateau.

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  • Experimental Study of Intrahepatic Biliary Perfusion by Contrast Enhanced Ultrasonography via Bile Duct

    ObjectiveTo explore the possibility of intrahepatic biliary perfusion by contrast enhanced ultrasonography via bile duct. MethodsSixteen rabbits weighing 2 000-2 500 g were studied. A 22 gauge catheter was inserted in the common bile duct by surgery. The rabbits were divided into 4 groups according to the concentration of contrast agent, including group A:1/100 of standard concentration; group B:1/200 of standard concentration; group C:1/400 of standard concentration; and group D:1/800 of standard concentration. We observed the filling status, presence of outflow of contrast enhanced signal and satisfactory enhanced time after the injection of contrast agent via the catheter in common bile duct. ResultsFive milliliter of contrast agent was injected in each rabbit. The number of homogeneous filling in group A, B, C and D was 4, 4, 3 and 0 respectively. The number of presence of outflow of contrast enhanced signal in group A, B, C and D was 4, 1, 0 and 0 respectively. The satisfactory enhanced time in group A, B, C and D was (340±29) s, (284±37) s, (82±8) s and 0 s respectively. There was no statistical difference in the satisfactory enhanced time between group A and B (P=0.06) while significant difference in the satisfactory enhanced time between group A and C (P < 0.01), and between group B and C (P < 0.01) was found. ConclusionIt is possible to perfuse the intrahepatic biliary system by sonographic contrast agents via bile duct, and 1/200 of standard concentration is a proper concentration of contrast agent to achieve satisfactory imaging.

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  • Application of Humanistic Ideas in High Quality Nursing Service in Grass-root Hospitals

    ObjectiveTo explore the effect of humanistic ideas applied for high quality nursing service in grass-root hospitals. MethodsIn the process of high quality nursing service between January 2011 and December 2013, humanistic philosophy was adopted. We provided humanistic nursing care for the patients, and humanistic management and care for doctors and nurses. Then, we used self-made questionnaire to do survey on the satisfaction degree in 1 200 patients, 500 nurses and 100 doctors in a third-grade class-A hospital. ResultsThrough the application of humanistic management idea, the satisfaction degree of all patients, nurses and doctors was significantly raised. ConclusionHumanistic concept applied in high quality nursing service inspires the enthusiasm and activity of nurses, promotes their nursing mode, and raise the nursing quality, which satisfies all the patients nurses and doctors.

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  • Expression of interleukin-17, interleukin-4 and interferon γ in experimental autoimmune uveoretinitis

    ObjectiveTo observe the expression of interleukin (IL)-17, IL-4 and interferon γ (IFN-γ) in experimental autoimmune uveoretinitis (EAU). MethodsC57BL/6 mice were immunized with interphotoreceptor retinoid-binding protein 1-20 to induce EAU. The inflammatory reaction before and on 7, 14, 21, 28 days after immunization were observed. The level of IL-17, IL-4 and IFN-γ in the serum were measured by enzyme-linked immune sorbent assay (ELISA). mRNA and protein expression of spleen and retina were analysed using quantitative reverse transcription-polymerase chain reaction (RT-PCR) and Western blot at the same time, respectively. ResultsThe most serious inflammatory reaction occurred at the 14th day after immunization. The highest level of IFN-γ in serum, highest mRNA and protein expression of IFN-γ in spleen and retina of mice occurred at day 7 after being immunized. The highest level of IL-17, IL-4 in serum, highest mRNA and protein expression of IL-17, IL-4 in spleen and retina of mice occurred at day 14 after being immunized. The increase degree of IL-17 was more than IFN-γ and IL-4. At 7, 14 and 21 days after immunization, compared with the pre-immunization, the level of IL-17, IL-4, IFN-γ in serum of mice were significantly increased (F=1 817.346, 268.600, 164.621; P < 0.05). There was no difference in the levels of IL-17, IL-4, IFN-γin serum of mice between pre-and 28 days after immunization (P > 0.05). At 7, 14 and 21 days after immunization, compared with the pre-immunization, the protein expression of IL-17, IL-4, IFN-γ in spleen (F=312.67, 114.250, 216.220) and retina (F=271.504, 85.370, 80.722) of mice were significantly increased (P < 0.05). There was no difference in protein expression of IL-17, IL-4, IFN-γ in spleen and retina of mice between pre-and 28 days after immunization (P > 0.05). ConclusionsThere were IL-17, IL-4 and IFN-γ expression in EAU. IL-17, IL-4 and IFN-γ play a key role in the occurrence and development of the EAU.

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  • Preliminary exploration on the application of hydrogel from acellular porcine adipose tissue to assist lipofilling

    ObjectiveTo investigate the effect of hydrogel from acellular porcine adipose tissue (HAPA) on the survival of transplanted adipose tissue.MethodsFor in vitro study, adipose tissue and HAPA-adipose tissue complex were cultured in normoxia and hypoxia atmospheres for 24 and 72 hours. TUNEL and Perilipin immunofluorescence staining were performed to observe the effect of HAPA on apoptosis and survival of adipocities. For in vivo study, 42 healthy male nude mice (4-6 weeks old) weighing 15-18 g were randomly divided into adipose group (group A), 10%HAPA group (group B), 20%HAPA group (group C), 30%HAPA group (group D), 40%HAPA group (group E), and 50%HAPA group (group F) according to different HAPA/adipose tissue volume ratio (n=7). For each group, 1 mL adipose tissue or HAPA-adipose tissue complex was injected subcutaneously into the dorsum of the nude mice. At 4 weeks after transplantation, 7 nude mice in each group were sacrificed and grafts were harvested, gross observation, volume measurement, ultrasound examination, and histologic staining (HE staining, CD31 and Perilipin immunofluorescence stainings) were applied.ResultsHypoxia showed a tendency of promoting adipose tissue necrosis and apoptosis, while HAPA exhibited an obvious effect of inhibiting cell apoptosis in vitro study (P<0.05). For in vivo study, grafts of all groups had intact fibrocapsule. No obvious signs of infection and necrosis were observed at 4 weeks. Volume shrinkage was observed in all groups, however, the groups A-D had significantly higher volume retention rate than groups E and F (P<0.05). Ultrasound examination showed that there were no significant difference in the number and volume of liquify area of the grafts in each group (P>0.05). With the increase of HAPA’s volume ratio, HE staining proved an improved fat integrity while a gradually decreased vacuoles and fibrosis. CD31 immunohistochemical staining showed that the number of neo-vascularisation in groups E and F were significantly higher than those in groups A-D (P<0.05). Perilipin immunofluorescence staining showed that with the increase of HAPA volume ratio, the number of living adipocytes increased gradually, and more new adipocytes could be seen in the field of vision.ConclusionAs the volume ratio of HAPA gradually increased, the survival of transplanted adipose tissue also increased, but the volume retention rate decreased gradually. 30%HAPA was considered the relative optimal volume ratio for its superior adipose tissue survival and volume retation rate.

    Release date:2020-11-02 06:24 Export PDF Favorites Scan
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