目的 探讨纤维乳管镜（FDS）联合液基薄层细胞学检查（TCT）在诊断非血性乳头溢液中的临床价值。方法 回顾性分析笔者所在医院2008年7月至2011年7月期间因非血性单侧单孔乳头溢液的176例住院患者的临床资料。所有患者均行FDS检查及冲洗液TCT，且均有明确的病理学诊断结果，比较联合法与单一FDS或TCT检查的诊断准确率。结果 FDS的诊断准确率为80.7%（142/176），TCT为53.4%（94/176），联合法为86.9% （153/176）。结论 FDS联合TCT对非血性乳头溢液的诊断准确率高，可以提高FDS检查阴性的乳腺疾病的检出率。
ObjectiveTo evaluate clinical value of indocyanine green (ICG) fluorescence in sentinel lymph node (SLN) biopsy (SLNB) for breast cancer. MethodThe SLNBs were performed in 66 patients with breast cancer,who were divided into ICG group (n=34) and methylene blue dye group (n=32) according to the tracing method. ResultsThe SLNs were found in 59 patients,the detection rate was 89.39%(59/66).One hundred and sixty-two SLNs in 59 patients were detected,the average number of detected SLNs was 2.75.The SLNs detection rate was 97.06%(33/34) and 81.25%(26/32) in the ICG group and in the methylene blue dye group,respectively,which in the ICG group was significantly higher than that in the methylene blue dye group (P<0.05).The positive SLNs were found in 32 cases,within which was 20 cases in the ICG group,12 cases in the methylene blue dye group.The axillary lymph node metastases were found in 35 of 66 cases,within which was 21 cases in the ICG group,14 cases in the methylene blue dye group.The sensitivity and false negative rate had no significant differences between the ICG group and the methylene blue dye group (sensitivity:95.2% versus 85.7%,P>0.05;false negative rate:4.8% versus 14.3%,P>0.05). ConclusionThe ICG fluorescence in SLNB for breast cancer has many advantages,including shorter time,simple operation,high sensitivity,and high detection rate as compared with methylene blue dye.