ObjectiveTo know the status and risk factors of occupational exposure in a top-class hospital in Sichuan, and provide the basis for occupational safety and protective measures. Methods"Hospital Medical Staff Occupational Exposure Registration Form" was used in this retrospective study. Statistical analysis was performed on medical workers' exposure data between January 2011 and June 2014 in a top-class hospital in Sichuan Province. ResultsA total of 139 cases of occupational exposures were recorded in some of the medical staff. There were more females than males. Nurses had the most exposures (70.5%), and the exposure sources were mainly human immunodeficiency virus and hepatitis B virus (27.9% and 21.0%, respectively). The exposure type was mainly sharp injury (84.2%). Exposure occurred mainly in surgery (47.5%), and different job or places had different exposure types with significant differences (χ2=12.683, 20.897, P<0.05). Sharp injury was mainly caused by the scalp needle and syringe, and the injured sites were mainly upper limbs (98.3%). However, exposure to blood and body fluids occurred mainly on upper limbs (54.5%) or face (45.5%). ConclusionOccupational exposures are mainly sharp injuries, especially in surgeries. Women, nurses or medical staff with low qualifications had the highest exposure risk. Thus, occupational safety and protection training should be strengthened.