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find Author "秦建伟" 3 results
  • Correlation Between Inflammation-related Gene Polymorphisms and Efficacy of Warfarin Therapy after Heart Valve Replacement Surgery

    ObjectiveTo clarify the relationship between the G/C polymorphism of inflammatory gene matrix metalloproteinase-2 (MMP2) and warfarin therapy after cardiac valve replacement (CVR). MethodsWe finally identified 96 patients who received additional warfarin therapy after CVR as a trial group and 78 patients without the warfarin therapy as a control group. Gene sequencing techniques were adopted to determine single nucleotide polymorphism allele. We analyzed genotype and clinical features of the two groups and explored the relationship between the different MMP2 geno-types and warfarin therapy after CVR. Logistic regression was used to analyze the correlation between genotypes and risk factors after CVR and Kaplan-Meier survival curves were performed to analyze the survival time and efficacy of patients carrying MMP2 GC and GG genotypes. ResultsThe distribution of MMP2 genotype in patients receiving warfarin therapy after surgery was different from that in patients without warfarin therapy. The results of multivariate logistic regression analysis showed that GC and GG genotypes were risk factors of complications of CVR. The proportion of GG genotype was higher in the patients with postoperative complications compared with those without. The survival time of patients carrying genotype MMP2 GG was shorter than those carrying GC genotype (P < 0.05), which reveals that the level of MMP2 GG genotype was associated with the prognosis. ConclusionG allele of MMP2 is a risk factor of complications following CVR. GG genotype is relevant to CVR and prognosis, which can be regarded as a risk factor post CVR.

    Release date:2016-11-04 06:36 Export PDF Favorites Scan
  • 抑肽酶在心肺转流术中对肺损伤的保护

    目的 探讨心肺转流术(cardiopulmonary bypass,CPB)导致肺缺血-再灌注损伤,抑肽酶对肺损伤保护的作用。方法 将24例心内直视手术的患者随机分为对照组和实验组,每组12例,实验组给予抑肽酶处理。检测CPB前后左、右心房血中性粒细胞和血小板计数,围手术期各时段桡动脉血浆中内皮素、血栓素B2、6-酮-前列腺素F1α和呼吸指数的变化。结果 对照组CPB后左、右心房血中血小板和中性粒细胞计数差异有显著性(P〈0.05);实验组CPB前后则差异无显著性;内皮素、血栓素B2、呼吸指数在CPB中、CPB后两组比较均差异有显著性(P〈0.01)。结论 CPB致肺损伤,血小板和中性粒细胞在肺内聚集,内皮素、血栓素B2、6-酮-前列腺素F1α在其病理过程中起重要作用。抑肽酶能通过干预这些因素而达到保护肺功能的

    Release date:2016-08-30 06:35 Export PDF Favorites Scan
  • Application of Molecular Targeted Drugs in Neoadjuvant Treatment of Breast Cancer

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