Systematic reviews provide information about the effectiveness of interventions by identifying, appraising, and summarizing the results of otherwise unmanageable quantities of primary research in an effort to provide valid, reliable evidence for health decision-making and clinical practice. They differ from traditional reviews produced by "content experts" in that they use a replicable, scientific and explicit approach that seeks to minimize bias. They are particularly useful when there is uncertainty regarding the potential benefits or harm of an intervention and when there are variations in practice. Poor quality systematic reviews may mislead policy-makers and clinicians. This paper will introduce the basic methods of Cochrane systematic reviews in order to help those who are interested in conducting systematic review.
【摘要】 目的 加强输血管理是保障血液合理利用和临床用血安全的重要手段。 方法 通过对医院临床用血情况的分析，以减少手术输血为切入点，采取强化意识，严控指征，完善术前准备，倡导自体输血，加强考核管理等方式促进临床合理用血。 结果 有效提升了医疗服务品质，保障医疗安全。 结论 其方法与措施此方法与措施供大型医院医疗管理参考借鉴。【Abstract】 Objective Strengthening blood transfusion management is an important means to ensure reasonable blood usage and clinical security during blood use. Methods With reducing surgery blood transfusion as a breakthrough point, We promotes clinical reasonable blood use and medical service quality by strengthening awareness of health workers, controlling indicators strictly, perfecting preoperative preparation, initiating autologous blood transfusion, enhancing assessment and management, and so on. Results The medical service quality was improved and the medical safety was ensured. Conclusion The experience could provide a reference for medical management in large hospitals.
Objective To evaluate the diagnostic value of anti-nucleosome antibody (AnuA) in patients with systemic lupus erythematosus (SLE). Methods We searched MEDLINE, EMbase and The Cochrane Library to identify studies on the diagnostic value of AnuA in patients with SLE. The searching time was from 1990 to 2005. The quality of included studies was evaluated and the data were extracted. The Cochrane Collaboration’s RevMan software was used to analyze heterogeneity, and MetaDisc was used to perform meta-analyses and draw summary receiver operator characteristic curve (SROC). Results Twenty-five studies involving 7 289 patients (2 459 SLE and 5 030 non-SLE patients were diagnosed by gold standard) were included, most of which were poor in quality. The heterogeneity among studies was high (Plt;0.000 01, I2=87.2%). The pooled sensitivity was 64.9%, 95% CI 63.0 to 66.85, and the pooled specificity was 92.6%, 95% CI 91.8% to 93.3%. Area under the SROC was 0.918, SE0.0212. These data suggested that AnuA had a relatively high false negative rate (35.1%) and a relatively low false positive rate (7.4%). Conclusions AnuA has some value in diagnosing SLE and could possibly be used as one of the diagnostic tests for SLE.