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find Keyword "程序性坏死" 4 results
  • 细胞程序性坏死的研究进展

    坏死是细胞死亡的3种表现形式之一,一直是生命科学的研究热点和难点。越来越多的研究发现坏死可被调节,并参与了许多疾病的病理生理过程。该文对目前研究涉及的有关细胞程序性坏死的特点、分子机制和病理生理特点加以综述。将来对其体内具体分子级联反应过程和分子级联反应过程的揭示,有利于更好地认识细胞生命过程,拓展包括肿瘤治疗在内的生命科学研究新领域。

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  • Preliminary Study of Necroptosis in Cardiac Hypertrophy Induced by Pressure Overload

    The aim of this study was to observe whether necroptosis is involved in the process of cardiac hypertrophy induced by pressure overload. SD rats underwent transverse abdominal aortic constriction (TAC) operation for establishing cardiac hypertrophy model. The structure and function of the left ventricle of rats were evaluated via echocardiography, left ventricular mass index, the expression of markers of cardiac hypertrophy and histological detection. Real-time PCR and Western blot were used to measure the gene and protein expression of receptor interacting protein kinase 1 and 3 (RIPK1 and RIPK3, the necroptosis markers) respectively. Four weeks after TAC operation, rat model for cardiac hypertrophy was established. The experimental data showed that the gene and protein expressions of RIPK1 and RIPK3 in the rat heart hypertrophic tissues after TAC for 4 weeks were increased significantly compared with those in the sham group. HE staining showed cardiomyocytes injury and hypertrophy in the hearts of TAC rat models. By transmission electron microscope, we observed that mitochondria of cardiomyocytes were damaged seriously in the TAC models. Treatment with losartan used, the selective antagonist of angiotensinⅡtypeⅠreceptor could improve the cardiac function of TAC rats. Moreover, losartan treatment decreased the expression of RIPK1 and RIPK3 in heart tissues of TAC rats. The results suggest that necroptosis occurrs in the process of cardiac hypertrophy with pressure overload, and losartan could alleviate the cardiac hypertrophy and inhibit necroptosis.

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  • 细胞程序化死亡在癫痫发生过程中的机制研究

    癫痫是一种病因复杂且发病机制尚未明确的慢性神经系统疾病。目前,国内外对癫痫开展了大量的研究。其中有研究认为,癫痫发生后,大脑海马区出现了一些结构性的改变,这些改变就包括细胞程序化死亡。细胞程序化死亡的方式主要有四种,分别是细胞自噬、细胞凋亡、程序性坏死和细胞焦亡,这四种死亡方式有着各自的特点和相应的机制。文章就细胞程序化死亡在癫痫发生过程中的相关机制作一综述,探讨癫痫发生分别与细胞自噬、细胞凋亡、程序性坏死和细胞焦亡的关系。

    Release date:2021-04-25 09:50 Export PDF Favorites Scan
  • Research progress of programmed necrosis in coronavirus disease 2019

    Patients with coronavirus disease 2019 may have systemic symptoms of varying degrees. These symptoms are related to inflammatory response, massive release of pro-inflammatory cytokines and cytokine storm. In recent years, programmed necrosis, as a controllable type of necrosis, is considered to be an important factor that mediates inflammation. Recent studies have shown that programmed necrosis is involved in the inflammatory response and pulmonary fibrosis of coronavirus disease 2019. This article mainly reviews the mechanism of programmed necrosis, its participation in the occurrence and development of coronavirus disease 2019, and the research progress of programmed necrosis inhibitors in the treatment of coronavirus disease 2019, aiming to provide a certain basis for the diagnosis and treatment of coronavirus disease 2019.

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