目的了解甲状腺原发性恶性淋巴瘤的特点，探讨其诊治方法。方法回顾分析我院收治的7例甲状腺原发性恶性淋巴瘤患者的临床表现，血清抗甲状腺球蛋白抗体（TGA）,抗甲状腺微粒体抗体（TMA），B超，核素扫描，病理组织学及免疫组织化学染色特点。结果7例患者均行手术切除和术后化疗，病理石蜡切片证实为甲状腺原发性恶性淋巴瘤，免疫组化染色显示白细胞共同抗原阳性，细胞角蛋白阴性，支持本诊断。治疗后随访4个月～11年患者均生存。结论病理检查是明确诊断的可靠依据，手术应尽可能切除肿瘤，术后予以化疗，治疗效果较为满意。
【Abstract】ObjectiveTo study the expressions of P-gp, nm23 and p53 in primary breast cancer tissues and to evaluate the prediction significance in recurrence of the primary breast cancer. MethodsExpressions of P-gp, nm23 and p53 in 57 benign and malignant breast paraffin-embedded specimens, the difference of the rate and intensity of positive reaction of P-gp,nm23 and p53 were checked by immunohistochemical staining.ResultsThe positive rate of nm23 significantly increased in benign breast tissues compared with the tissues of recurrence of breast cancer. The positive intensity of nm23 was significantly decreased in the tissues of recurrence of breast cancer compared with the tissues of primary breast cancer. The positive rate of p53 was significantly increased in malignant breast tissues compared with benign breast tissues. The positive intensity of p53 was significantly increased in the tissues of recurrence of breast cancer compared with the tissues of primary breast cancer. There was no difference in the positive rate of P-gp in the tissue of recurrence and primary of breast cancer compared with benign breast tumor. But the positive intensity of P-gp was significantly decreased in the tissues of recurrence and primary of breast cancer compared with benign breast tumor. ConclusionThe expression of p53 may indicate the proliferating activity of carcinoma cell. The positive intensity of expression of p53 and nm23 is valuable in prediction of the recurrence of primary breast cancer.