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find Keyword "糖化血红蛋白" 17 results
  • Anti-interference hemoglobin analysis system by high performance liquid chromatography

    High performance liquid chromatography (HPLC) is currently the mainstream technology for detecting hemoglobin. Glycated hemoglobin (HbA1c) is a gold indicator for diagnosing diabetes, however, the accuracy of HbA1c test is affected by thalassemia factor hemoglobin F (HbF)/hemoglobin A2 (HbA2) and variant hemoglobin during HPLC analysis. In this study, a new anti-interference hemoglobin analysis system of HPLC is proposed. In this system, the high-pressure three-gradient elution method was improved, and the particle size and sieve plate aperture in the high-pressure chromatography column and the structure of the double-plunger reciprocating series high-pressure pump were optimized. The system could diagnose both HbA1c and thalassemia factor HbF/HbA2 and variant hemoglobin, and the performance of the system was anti-interference and stable. It is expected to achieve industrialization. In this study, the HbA1c and thalassemia factor HbF/HbA2 detection performance was compared between this system and the world’s first-line brand products such as Tosoh G8, Bio-Rad Ⅶ and D10 glycosylated hemoglobin analysis system. The results showed that the linear correlation between this system and the world-class system was good. The system is the first domestic hemoglobin analysis system by HPLC for screening of HbA1c and thalassemia factor HbF/HbA2 rapidly and accurately.

    Release date:2021-12-24 04:01 Export PDF Favorites Scan
  • The Relationship between Type-2 Diabetes and HbA1c Levels, and Postoperative Cognitive Dysfunction in Elderly Patients

    ObjectiveTo study the correlation of postoperative cognitive dysfunction (POCD) with type-2 diabetes and glycosylated hemoglobin (HbA1c) levels in elderly patients. MethodsA total of 140 elderly patients who were going to undergo non-cardiothoracic surgery in our hospital between January 2011 and February 2013 were included in this study.ASA classification was between I and Ⅲ.There were 78 males and 62 females,aged between 65 and 86 years old.Group A had 70 patients with diabetes,while group B had another 70 corresponding patients without diabetes.One day before surgery and a week after surgery,Mini-mental State Examination (MMSE) and Montreal Cognitive Functioning Scale (MoCA) were used to test patients'cognitive function,and the incidence of POCD was compared between the two groups.Group A patients,according to HbA1c levels,were divided into group AH (HbA1c>7.5%) and group AL (HbA1c<7.5%).And we compared the relationship between group AL and group B,and the relationship between group AH and group B. ResultsThe incidence of POCD in group A was significantly higher than that in group B (P<0.05).Group AH had a significantly higher incidence of POCD than group AL (P<0.05).No significant difference was found in fasting plasma glucose among the groups. ConclusionElderly diabetic patients with poor glycemic control is a risk factor for POCD occurrence,but fasting glucose as a predictor of POCD is not as good as HbA1C.

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  • Correlation between HbA1c on admission and blood glucose fluctuations and adverse events after coronary artery bypass grafting in non-diabetic patients

    ObjectiveTo explore the relationship between glycated hemoglobin (HbA1c) level and blood glucose fluctuations after coronary artery bypass grafting (CABG) and adverse events in non-diabetic patients, thus providing theoretical support for intensive preoperative blood glucose management in patients undergoing CABG surgery.MethodsA total of 304 patients undergoing CABG with or without valvular surgery from October 2013 to December 2017 were enrolled in this prospective, single-center, observational cohort study. We classified them into two different groups which were a low-level group and a high-level group according to the HbA1c level. There were 102 males and 37 females, aged 36–85 (61.5±9.5) years in the low-level group, and 118 males and 47 females aged 34–85 (63.1±9.4) years in the high-level group. The main results were different in hospital mortality and perioperative complications including in-hospital death, myocardial infarction, sternal incision infection, new stroke, new-onset renal failure and multiple organ failure. To assess the effects of confounding factors, multivariate logistic regression analysis was used.Results Postoperative blood glucose fluctuation was more pronounced in the high-level group than that in the low-level group before admission [0.8 (0.6, 1.2) mmol/L vs. 1.0 (0.8, 1.8) mmol/L, P<0.01]. This study also suggested that the incidence of major adverse events was significantly lower in the low-level group compared with the high-level group (P=0.001). Multivariate logistic regression analyses to correct the influence of other confounding factors showed that HbA1c (OR=2.773, P=0.002) and postoperative blood glucose fluctuations (OR=3.091, P<0.001) could still predict the occurrence of postoperative adverse events.ConclusionHbA1c on admission can effectively predict blood glucose fluctuations in 24 hours after surgery. Secondly, HbA1c on admission and postoperative blood glucose fluctuations can further predict postoperative adverse events. It is suggested that we control the patient's preoperative HbA1c at a low level, which is beneficial to control postoperative blood glucose fluctuation and postoperative adverse events.

    Release date:2019-09-18 03:45 Export PDF Favorites Scan
  • Diagnostic value of shear wave elastography combined with vascular endothelial growth factor B and hemoglobin A1c in early diabetic peripheral neuropathy

    Objective To analyze the diagnostic value of shear wave elastography (SWE) combined with vascular endothelial growth factor B (VEGF-B) and hemoglobin A1c (HbA1c) in early diabetic peripheral neuropathy (DPN). Methods A total of 100 patients with type 2 diabetes mellitus (T2DM) admitted to Mianyang Central Hospital between October 2020 and October 2023 were selected and divided into a T2DM with DPN group (n=31) and a T2DM without DPN group (n=69) based on the presence or absence of DPN. Additionally, 50 healthy individuals from the same hospital’s health examination center were included as a healthy control group. The basic clinical characteristics, mean elasticity (Emean) values of the left and right median and tibial nerves, serum VEGF-B, and HbA1c levels were compared among the three groups. The diagnostic efficacy of SWE, VEGF-B, and HbA1c for DPN was evaluated using receiver operating characteristic (ROC) curves, and Pearson correlation analysis was performed to assess the relationships between median/tibial nerve Emean and VEGF-B/HbA1c. Results The Emean values of the left and right median nerves, Emean values of the left and right tibial nerves, serum VEGF-B, and HbA1c levels in the T2DM with DPN group were significantly higher than those in the T2DM without DPN group and the healthy control group (P<0.05). The Emean values of the left and right median and tibial nerves, Emean values of the left and right tibial nerves, and HbA1c level in the T2DM without DPN group were significantly higher than those in the healthy control group (P<0.05), while no significant difference was observed in serum VEGF-B level between the T2DM without DPN group and the healthy control group (P>0.05). The area under the ROC curve for the combined diagnosis of DPN using SWE, VEGF-B, and HbA1c was 0.859 [95% confidence interval (0.828, 0.955)]. The sensitivity of the combined diagnosis (93.72%) was significantly higher than that of individual diagnoses (78.82%, 75.39%, and 71.05%, respectively; P<0.05), while the specificity (88.64%) showed no significant difference compared to individual diagnoses (80.18%, 78.96%, and 82.88%, respectively; P>0.05). Positive correlations were observed between median/tibial nerve Emean and VEGF-B/HbA1c levels (r=0.428, 0.395, 0.416, and 0.416, respectively; P<0.05). Conclusions Elevated median/tibial nerve Emean, serum VEGF-B, and HbA1c levels are closely associated with DPN. The combination of SWE, VEGF-B, and HbA1c improves diagnostic sensitivity for DPN, demonstrating significant clinical value.

    Release date:2025-05-26 04:29 Export PDF Favorites Scan
  • 糖化血红蛋白检测结果的置信区间

    目的 应用生物学变异和分析变异探讨糖化血红蛋白(glycosylated hemoglobin,HbA1c)测定结果对糖尿病诊断治疗的影响。 方法 以三级质量规范为标准,应用 HbA1c 生物学变异和参考变化值,分析实验室测量固有分析变异(analytical variance,CVA)、个体内生物学变异(within-individual variation,CVI)以及偏倚对 HbA1c 测定结果的影响。 结果 HbA1c 的测定结果随 CVA 的增加而导致的额外偏倚不呈线性增加。不同的生物学变异质量规范要求对 HbA1c 测定结果的影响有差异。不同的 CVA 对非糖尿病个体和糖尿病患者的 HbA1c 测定结果离散范围影响不同。HbA1c 检测要求分析方法的 CVA<3%。 结论 糖尿病诊断和治疗并不能单独依赖 HbA1c 测定结果的实际数值为判断标准。应结合 CVA 及 CVI 对于 HbA1c 测定值偏倚的影响给出测定值,并附上置信区间。

    Release date:2017-07-21 03:43 Export PDF Favorites Scan
  • 测定糖化血红蛋白诊断妊娠期糖尿病的意义

    目的 探讨糖化血红蛋白(HbAlc)测定在妊娠期糖尿病(gestationa l diabetes mellitus, GDM)诊断中的意义。 方法 选择2006年3月-2008年12月确诊的GDM患者35例为观察组,同期健康女性和正常妊娠组各30例为对照组。均清晨空腹采静脉血,测定FPG和HbAlc, GCT:口服50 g葡萄糖溶于250 mL水中的葡萄糖液,5 min内服下,1 h后采集静脉血测血糖。 结果 正常妊娠组FPG、GCT和HbA1c与健康对照组差异无统计学意义(P>0.05), GDM组FPG、GCT和HbA1c比正常妊娠组显著增高,差异有统计学意义(P<0.05);GDM组FPG、GCT和HbA1c阳性率分别是42.9%,85.7%和82.9%,阳性检出率大小顺序依次为GCT>HbA1c>FPG。 结论 HbA1c可作为GDM诊断的指标推广。

    Release date:2016-09-08 09:47 Export PDF Favorites Scan
  • Association among Fructosamine and Blood Glucose, Glycated Hemoglobin

    【摘要】 目的 探讨果糖胺(fructosamine,FMN)与血糖、糖化血红蛋白(HbA1c)的关系。 方法 2009年5月-2009年8月,以75例糖尿病患者作为糖尿病组,36例健康志愿者作为正常对照组,进行口服糖耐量试验,检测其空腹血糖及餐后2 h血糖水平,并同时检测FMN与HbA1c水平。 结果 糖尿病组空腹血糖、餐后2 h血糖、FMN、HbA1c均高于正常对照组(Plt;0.05)。FMN与HbA1c、空腹血糖、餐后2 h血糖均呈正相关关系(Plt;0.05)。FMN与空腹血糖的相关系数高于HbA1c与空腹血糖的相关系数,FMN与餐后血糖的相关系数也高于HbA1c与餐后血糖的相关系数。 结论 果糖胺与HbA1c相比有一定的优势,可作为监测糖尿病患者血糖控制的良好指标。【Abstract】Objective To investigate the association among fructosamine (FMN) and blood glucose, glycated hemoglobin (HbA1c). Methods From May 2009 to April 2009, 75 diabetes and 36 health subjects were recruited for this study. Blood samples was collected and assayed for FMN, HbA1C, and fasting glucose.The 2-hour oral glucose tolerance test (OGTT-2h) was given. Results Fasting glucose, OGTT-2h glucose, FMN and HbA1c were all higher in diabetes group than in healthy control group (Plt;0.05) .There was positive correlation between FMN and fasting glucose, OGTT-2h glucose, and HbA1c (Plt;0.05). The correlation coefficients between FMN and glucose were higher than those between HbA1c and glucose. Conclusion Compared with HbA1c, FMN has advantage in monitoring blood glucose in diabetes and be regarded as a suitable index for blood glucose control.

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  • 糖化血红蛋白测定对骨折患者高血糖状态判定价值

    目的 探讨糖化血红蛋白(HbA1c)在骨折患者中糖尿病诊断和筛查的价值。 方法 2009年3月-6月测定502例因骨折住院患者的空腹血糖(FBG)和HbA1c。 结果 502例患者,血糖异常350例,而糖化血红蛋白≥7%只有39例,经糖耐量确诊为糖尿病36例。 结论 对于骨折患者,由于应激性反应,FBG波动性较大,HbA1c的测定对因骨折应激性反应而引起FBG异常的筛查有一定价值

    Release date:2016-09-08 09:47 Export PDF Favorites Scan
  • Study on the association between glycosylated hemoglobin level and poor prognosis of intravenous thrombolysis in patients with acute ischemic stroke

    ObjectiveTo explore the association between glycosylated hemoglobin level and poor prognosis in acute ischemic stroke (AIS) patients treated with intravenous thrombolysis.MethodsThe AIS patients treated with recombinant tissue-type plasminogen activator who were hospitalized in the Department of Neurology of the First Affiliated Hospital of Henan University of Science and Technology from September to December 2020 were retrospectively included. According to different levels of glycosylated hemoglobin, they were divided into pre-diabetic group (5.7%≤glycated hemoglobin≤6.4%), diabetic group (previously diabetic or glycosylated hemoglobin≥6.5%), and non-diabetic group (glycated hemoglobin <5.7%). The relevant information of the patients was collected, and a telephone follow-up was conducted 90 days after discharge. According to the modified Rankin Scale (mRS) score, the patients were divided into the good prognosis group (mRS score≤2) and the poor prognosis group (mRS score>2). Logistic regression analysis was used to determine the risk factors for the poor prognosis of intravenous thrombolysis in patients with AIS.ResultEventually 101 patients were included, including 44 in the non-diabetic group, 24 in the pre-diabetic group, and 33 in the diabetic group. And 64 patients were in the good prognosis group and 37 patients were in the poor prognosis group. Regression analysis results showed that diabetes was associated with poor prognosis 3 months after intravenous thrombolysis in patients with AIS [odds ratio=6.518, 95% confidence interval (1.568, 27.096), P=0.010]; and the higher the National Institutesof Health Stroke Scale score at admission was, the higher the risk of poor prognosis would be [odds ratio=1.421, 95% confidence interval (1.231, 1.640), P<0.001].ConclusionIn AIS patients who received intravenous thrombolysis, diabetes is associated with poor prognosis after 3 months.

    Release date:2021-07-22 06:28 Export PDF Favorites Scan
  • 高原人群糖化血红蛋白的研究进展

    在多项血糖监测的指标中,糖化血红蛋白(hemoglobin A1c,HbA1c)目前是在评价血糖管理、治疗方案有效性及防控糖尿病并发症中运用最广泛且最重要的指标。然而高原低氧、低气压及民族等因素对 HbA1c 水平影响的结论仍存在争议,该文就高原环境及民族差异对 HbA1c 的具体影响及可能的机制进行了综述。

    Release date:2017-12-25 06:02 Export PDF Favorites Scan
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