【摘要】 目的 评价经皮冠状动脉成形术（percutaneous coronary interventions，PCI）术后，穿刺股动脉应用Perclose ProGlide血管缝合器止血的安全性、可靠性及对常见并发症的防范。 方法 2007年4月-2009年5月，收治217例经股动脉PCI术后患者，根据术后是否使用血管缝合器将患者随机分成血管缝合器组（105例）和对照组（经手法压迫止血112例）。观察记录两组患者下肢制动时间及血管并发症等。 结果 血管缝合器组103例操作成功（98.1%），2例失败；对照组成功112例（100%）。两组成功率比较，差异无统计学意义（Pgt;0.05）。血管缝合器组和对照组患者下肢制动时间分别为（4.1±1.2）和（25.0±3.1）h，两组比较，差异有统计学意义（Plt;0.01）。术后两组并发症发生率比较，差异无统计学意义（Pgt;0.05）。 结论 血管缝合器是一种安全、可靠的止血方法，可明显缩短制动时间，无明显的穿刺部位血管并发症，熟练操作可减少并发症的发生。【Abstract】 Objective To evaluate the safety of Perclose ProGlide Suture-Mediated Closure System applied to femoral artery puncture site after percutaneous coronary interventions (PCI) and to explore the prevention of possible common complications. Methods A total of 217 patients who underwent PCI from April 2007 to May 2009 were randomly divided into Perclose ProGlide group (105 patients, hemostasis by Perclose ProGlide Suture-Mediated Closure System) and control group (112 patients, hemostasis by compression). The Lower-limb braking time and the complications were recorded and analyzed. Results The successful rate was 98.1% (103 patients) in Perclose ProGlide group, and 100% (112 patients) in the control group; the difference between the two groups was not significant (Pgt;0.05). But there was a significant difference (Plt;0.01) in Lower-limb braking time between the two groups[(4.1±1.2) and (25±3.1) hours]. The post-operative complications between the two groups didn’t differ much. Conclusions Perclose ProGlide Suture-Mediated Closure System is a safe,effective and simple method after percutaneous coronary intervention to achieve immediate hemastasis. Skillfully processing may reduce the vascular complications.