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find Author "罗庆" 3 results
  • EXPRESSION OF MECHANO-GROWTH FACTOR AND ITS ROLES IN TISSUE REPAIRS AND REGENERATION/

    Objective To review the expression of mechano-growth factor (MGF) and its roles in tissue repairs andregeneration. Methods The l iterature about the expression of MGF and its roles in tissue repairs and regeneration in recentyears was reviewed. Results MGF is sensitive to mechanical stimulation and can be expressed in various tissues/cells. MGF isresponsible for satell ite cell activation, myoblast proliferation, and plays important roles in the treatment of muscle coloboma,prevention of myocardial injury, and neuroprotection. Conclusion The important role of MGF in tissue repairs andregeneration has been identified, however, the detailed mechanisms remain unclear up to now and still need a further study.

    Release date:2016-08-31 04:23 Export PDF Favorites Scan
  • 骨桥蛋白对肿瘤细胞恶性行为影响的研究进展

    骨桥蛋白(osteopontin,OPN)是在多种组织中广泛存在的一种分泌型糖蛋白,与癌症的发生和进程有密切的关系,是癌症的标志物之一。肿瘤细胞的恶性行为直接影响癌症的治疗和预后,近年来相关研究发现,OPN 以多种方式促进肿瘤细胞恶性行为。研究 OPN 对肿瘤细胞抗凋亡、血管生成、侵袭、干性维持等恶性行为的影响以及 OPN 在癌症中的诊断意义,有利于为基于 OPN 的针对性治疗方案的提出而提供理论参考。因此,该文从表型、分子机制和诊断意义几个方面讨论 OPN 对肿瘤细胞恶性行为的影响。

    Release date:2017-12-25 06:02 Export PDF Favorites Scan
  • Effect of Conditioned Medium from Endothelial Cells on Cancer Stem Cell Phenotype of Hepatoma Cells

    In this study, we aimed to investigate the influences of conditioned medium from human umbilical vein endothelial cells (HUVEC) on cancer stem cell phenotype of human hepatoma cells. HUVEC and human hepatoma cells (MHCC97H) were cultured, respectively, and then the MHCC97H cells were co-cultured with conditioned medium from HUVEC (EC-CM) with Transwell system. Anti-cancer drug sensitivity, colony-formation, migration/invasion ability, expression of cancer stem cell marker and sphere formation were performed to determine the cancer stem cell phenotype in MHCC97H cells. We found that MHCC97H cells co-cultured with EC-CM exhibited significantly higher colony-formation ability and lower sensitivity of anti-cancer drugs 5-FU and Cis. Transwell assay showed that treatment with EC-CM obviously increased migration and invasion of MHCC97H cells. Moreover, increased sphere forming capability and expression of CD133 in MHCC97H cells were observed after co-cultured with EC-CM. These results suggested that EC-CM could promote cancer stem cell phenotype of hepatoma cells.

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