Objective To investigate the protective effects of ulinastatin on acute lung injury ( ALI)induced by seawater drowning in rats. Methods Thirty male SD rats were randomly divided into three groups, ie. a control group, a model group, and an ulinastatin treatment group. The rats in the model group and the ulinastatin treatment group received intratracheal artificial seawater ( 4 mL/kg) instillation. Then the ulinastatin treatment group received ulinastatin ( 100 000 U/kg) injection after infusion of seawater while the model group received an injection of same amount of saline. The rats were sacrificed at 4 hours after instillation. The pathological changes of lung were evaluated by hematoxylin-eosin stain under light microscope. Lung wet/dry weight ratios were measured to assess the level of pulmonary edema.Concentrations of tumor necrosis factor ( TNF) -α, interleukin ( IL) -1β, IL-6, and IL-10 in bronchoalveolar lavage fluid ( BALF) were detected by enzyme-linked immunosorbent assay ( ELISA) . The myeloperoxidase activity in lung tissue homogenates were measured by colorimetric method. Results Ulinastatin treatmentsignificantly relieved the decline of PaO2 and lung pathological changes, inhibited myeloperoxidase activity,and reduced lung wet/dry weight ratios. Ulinastatin also inhibited the release of TNF-α, IL-1β, and IL-6,whereas increased the expression of IL-10 simultaneously. Conclusion Ulinastatin attenuates seawater induced ALI, which may be related to its inhibitory effects on inflammation reaction through regulating cytokine secretion.
目的:分析不典型肺癌CT误诊的原因,以提高对不典型肺癌的认识水平。方法:回顾性经手术、病理及细胞学检查证实的不典型肺癌误诊病例65例的临床及CT资料。其中胸部CT平扫20例,平扫+增强扫描45例。结果:误诊为肺结核28例,肺炎23例,慢性阻塞性肺病11例,支气管扩张2例,肺脓肿1例。误诊时间1～11个月。结论:不典型肺癌CT表现呈多样性,当肺部有多发病灶特别是合并基础疾病时,容易造成误诊。反复脱落细胞检查、及时纤支镜检、穿刺活检及密切随访复查是减少不典型肺癌误诊的有效方法。
ObjectiveTo explore the correlation between coronary artery plaque composition and the gender via 128-slice spiral CT coronary angiography (128-SCTCA). MethodsBetween January and December 2012, 143 patients with coronary artery plaque diagnosed by 128-SCTCA were selected. The patients were divided into group A (no more than 50 years old, n=37) and group B (over 50 years old, n=106). ResultsThere were 29 male patients in group A, with 70 plaques including 30 fibrous plaques, 17 mixed plaques, 11 soft plaques, 12 calcified plaques; and the other 8 female patients had 13 plaques including 7 fibrous plaques, 2 mixed plaques, 2 soft plaques, and 2 calcified plaques. In group B, 56 male patients had 116 plaques, including 48 mixed plaques, 40 fibrous plaques, 14 soft plaques and 14 calcified plaques; the other 50 female patients had 90 plaques, including 36 mixed plaques, 22 fibrous plaques, and 16 soft plaques and calcified plaques. The differences of the plaque composition between males and females were not significant both in group A (χ2=0.664, P>0.05) and group B (χ2=3.708, P>0.05). ConclusionThere is no obvious correlation between gender and coronary plaque composition.
目的 应用128层螺旋CT冠状动脉成像，探讨冠状动脉不同成分斑块与狭窄程度的诊断价值。 方法 对2010年3月－2012年10月150例临床拟诊冠心病及确诊冠心病患者的128层螺旋CT冠状动脉成像检查，冠状动脉影像表现由两位心血管CT诊断医师独立判断冠状动脉斑块成分及测量冠状动脉狭窄程度。应用Circulation血管分析软件，分析冠状动脉斑块成分与狭窄程度之间的相关性。 结果 150例患者中，共发现319处斑块，其中软斑块104处，纤维、混合斑块103处，钙化斑块112处。冠状动脉轻度狭窄114处中，钙化斑块86处 （75.4%）；冠状动脉中度狭窄113处中，纤维、混合斑块75处（66.3%）；冠状动脉重度狭窄92处中，软斑块68处（73.9%）。 结论 128层螺旋CT冠状动脉成像能够有效检测患者冠状动脉斑块的成分及准确判断冠状动脉狭窄程度。