Objective To evaluate the clinical effectiveness of different surgical treatments for recurrent pterygium. Methods Databases such as The Cochrane Library, PubMed (1966 to 2011), EMbase (1989 to 2011), CNKI (1979 to 2011), VIP (1989 to 2011) and WanFang Data (1982 to 2011) were electronically searched for randomized controlled trials (RCTs) on different surgical treatments for recurrent pterygium, and the relevant references were also retrieved. According to the inclusion criteria, we screened literature, extracted data, and critically assessed the quality of RCTs. Then the meta-analysis was conducted using RevMan 5.0 software. Results A total of 19 RCTs were included. The results of meta-analyses showed, limbal stem cell autograft transplantation (LAT) combined with amniotic membrane transplantation (AMT), LAT alone, and intraoperative using of mitomycin C, effectively reduced the recurrence rate of recurrent pterygium. Statistic differences were found (Plt;0.01) when they were compared with conventional pterygium excision alone or plus AMT. Conclusion Current evidence shows LAT+AMT, LAT alone, and intraoperative using of mitomycin C can effectively reduce the recurrence rate of recurrent pterygium. But this conclusion still needs to be proved by large-scale RCTs due to the limited quantity and quality of the included studies.
目的 观察两种手术方式治疗翼状胬肉的临床效果。 方法 对2007年1月－2012年6月一般情况较好的73例单纯原发性双眼翼状胬肉患者进行了回顾性研究，比较同一患者双眼分别行翼状胬肉切除+生物羊膜移植（左眼）和翼状胬肉切除+自体角膜缘干细胞移植（右眼）手术后痊愈率、复发率及并发症。 结果 行翼状胬肉切除+自体角膜缘干细胞移植（右眼）的痊愈率达93.15%，复发率1.37%，并发症率5.48%，其痊愈率更高而复发率及并发症均更低。 结论 翼状胬肉切除+自体角膜缘干细胞移植用于治疗翼状胬肉比翼状胬肉切除+人工羊膜移植的疗效更好，值得临床推广。
目的:观察新鲜羊膜移植联合丝裂霉素C治疗复发性翼状胬肉的临床疗效。方法:对32例(38眼)复发性翼状胬肉行翼状胬肉切除联合新鲜羊膜移植加丝裂霉素C治疗,观察术后角膜上皮愈合、胬肉复发情况。结果:术后随访3～24个月,有2眼复发,复发率为5.26%。结论:新鲜羊膜移植联合丝裂霉素Ｃ治疗复发性翼状胬肉降低了复发率,无严重手术并发症,是一种安全有效的手术方法。