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find Keyword "肉瘤" 99 results
  • 中药与骨肉瘤耐药逆转研究探讨

    【摘要】肿瘤多药耐药(multidrug resistance,MDR) 是制约肿瘤成功化疗的重要因素之一,逆转MDR治疗恶性肿瘤是肿瘤治疗的有效策略,但由于肿瘤MDR机制复杂,耐药逆转药物作用靶点及机制单一,其治疗效果并不理想。中药抗肿瘤及耐药逆转具有高效低毒、多靶点、多阶段性等作用特点及其他优点,可针对肿瘤多药耐药的多种机制进行有效逆转。MDR亦是骨肉瘤化疗的主要障碍,骨肉瘤及其耐药有其特殊性,根据骨肉瘤耐药机理及中药耐药逆转机理,中药有潜力开发成为低毒高效的骨肉瘤耐药逆转剂,可能成为骨肉瘤治疗的理想药物。

    Release date:2016-08-26 02:21 Export PDF Favorites Scan
  • Clinicopathological Analysis of Cutaneous Angiosarcoma on the Scalp and Face in Elder Patients

    【摘要】 目的 探讨老年人头面部脉管肉瘤的临床病理学特征。 方法 1996年-2008年对5例老年人头面部脉管肉瘤的临床资料、病理形态学、免疫组织化学染色进行观察,并对其中4例进行了随访。 结果 临床表现主要是头面部发生的瘀斑、溃疡或结节状病变。肿瘤细胞围绕皮肤附件周围排列成交通状吻合的血窦网,衬覆有异型性的内皮细胞,有的区域内皮细胞形成乳头状突起。肿瘤组织内有不同程度的弥漫性出血。肿瘤细胞表达CD34、CD31、Fli-1和FⅧ,部分表达CD117和CK8/18。经随访3例3年内死亡,1例带瘤存活1年余,1例失访。 结论 老年人头面部脉管肉瘤组织形态多样,预后较差,及时诊治十分重要。需要与其他皮肤良性血管病变和低分化癌、恶性黑色素瘤、恶性梭形细胞肿瘤、Kaposi肉瘤等鉴别。【Abstract】 Objective To explore the clinicopathological features of cutaneous angiosarcoma on the scalp and face in elder patients. Methods The clinical data of five elder patients with cutaneous angiosarcoma on the scalp and face from 1996 to 2008 were retrospectively analyzed. The patients underwent the light microscopy, pathomorphological examination, and immunohistochemistry. Four patients were followed up. Results Most clinical manifestation was dusky irregular erythematous plaques which were often ulcerated. The tumor was composed of asymmetric collection of angulated and irregular vascular spaces infiltrating between collagen bundles. Endothelial cells attaching to the vascular spaces had hyperchromatic irregular nuclei and prominent nucleoli. Hemorrhage was another histologic feature. Positive expression of CD34,CD31,Fli-1 and FⅧ were found in tumor cells, and expression of CD117 and CK8/18 was found in some of the patients. In the follow-up duration, three patients died in three years, and one failed to be followed up. Conclusion Cutaneous angiosarcoma of the scalp and face has various histomorphology and poor prognosis, which should be diagnosed and treated in time. It should be distinguished from benign cutaneous hemangioma, poorly differentiated carcinoma, malignant melanoma and malignant spindle cell tumor.

    Release date:2016-08-26 02:21 Export PDF Favorites Scan
  • Cutaneous Leiomyosarcoma:A Clinic Pathologic Study of Two Cases

    摘要:目的:探讨皮肤平滑肌肉瘤的临床病理特点和诊断要点及预后。方法:对2例皮肤平滑肌肉瘤组织病理学、免疫组化观察,并复习相关文献。结果: 例1为皮下平滑肌肉瘤,具有结节型的生长形态,瘤细胞丰富,异型性较大,核分裂活跃;例2为真皮平滑肌肉瘤,具有弥漫型的生长形态,瘤细胞较少,分化好,核分裂象不明显。免疫组化2例均表达SMA、MSA、Vim,1例灶性表达Desmin。2例随访迄今均无复发及转移。结论:皮肤平滑肌肉瘤少见,可分为真皮和皮下两种类型,两者具有不同的组织起源和预后特点,我们要注意区分,诊断除核分裂象计数外,尚需进行综合评估,对某些病例建议采用恶性潜能未定的平滑肌肉瘤的诊断,治疗首选外科手术切除。Abstract: Objective: To investigate the clinic pathological features diagnosis main point and prognosis of cutaneous leiomyosarcoma(CLMS).Methods:Histopathology,immunohistochemical stainings observation were analyzed in two cases of CLMS and the related literatures were reviewed. Results:Case 1 was subcutaneous leiomyosarcoma with tubercular growth pattern,rich tumor cell,big heterogeneous type,active mitotic;Case 2 was dermis leiomyosarcoma with diffuse growth pattern,few tumor cell,well differentiated,no more mitotic. Immunohistochemically,the two cases reacted positively with smooth muscle action、MSA and Vim,Case 1 also expressed desman partially. The two cases were revisited to date,no recurrences and metastases.Conclusion:Cutaneous leiomyosar coma is a rare tumor,subdivided into dermis and subcutaneous forms because of their different tissue origins and prognosis features. We must discriminate between them. Diagnosis need synthetic appraisal besides mitotic counts and “smooth muscle tumor of uncertain malignant potential” should be used for diagnosis of certain cases.Primary treatment for cutaneous leiomyosarcoma is surgical excision.

    Release date:2016-08-26 03:57 Export PDF Favorites Scan
  • Diagnosis and Treatment of 23 Cases with Primary Retroperitoneal Liposarcoma

    目的 总结原发性腹膜后脂肪肉瘤(primary retroperitoneal liposarcoma,PRL)的临床病理特征、诊断及治疗方法。 方法 回顾性分析经手术和活检证实的23例PRL患者的临床病理资料。结果 首发症状及体征表现为腹部肿块(91.3%,21/23),腹胀(56.5%,13/23)及腹痛(30.4%,7/23)。B超及CT的定位诊断准确率分别为66.7%(12/18)和85.7%(12/14)。首次手术肿瘤完整切除16例(69.6%),其中8例联合脏器切除; 部分切除3例(13.0%); 仅行活检4例(17.4%)。PRL肿瘤完整切除术后复发率为75.0%(12/16),该12例中再次手术8例(66.7%)可完全切除肿瘤。结论 CT是诊断PRL的重要手段,优于B超; 手术以完整切除肿瘤为主,对侵犯脏器者采用累及脏器一并切除; 术后复发者可再次手术。

    Release date:2016-08-28 04:08 Export PDF Favorites Scan
  • Diagnosis and Treatment of Cystosarcoma Phyllodes and GiantFibroadenomas of Breast (Report of 〖STHZ〗17 Cases)

    目的 探讨乳腺叶状囊肉瘤和巨纤维腺瘤的诊断和治疗。方法 回顾分析我院1985~2002年期间外科收治的9例乳腺叶状囊肉瘤和8例乳腺巨纤维腺瘤的临床资料。结果 9例乳腺叶状囊肉瘤中行单纯乳房切除术4例,保留乳头皮下乳房切除术1例,保留乳头和部分压缩腺体+肿块切除术1例,改良根治术3例; 术后恢复良好,仅1例复发。8例乳腺巨纤维腺瘤中行单纯乳房切除术2例,保留乳头皮下乳房切除术1例,保留乳头和部分压缩腺体+肿块切除术2例,单纯乳腺肿块切除术3例; 术后恢复良好,术后2例复发。结论 乳腺叶状囊肉瘤和巨纤维腺瘤临床上均表现为无痛性包块,除乳腺叶状囊肉瘤发病年龄较大、肿块范围大及易恶变外,二者主要依据病理检查结果相鉴别; 均以手术治疗为主,根据患者年龄、肿块大小以及病理检查结果选择不同的手术方式。

    Release date:2016-08-28 04:08 Export PDF Favorites Scan
  • THE SIGNIFICANCE OF CYCLIN D1 AND P53 PROTEIN EXPRESSION IN BREAST CARCINOMA AND FIBROSARCOMA INDUCED BY DMBA IN RATS

    【Abstract】Objective To investigate the significance of cyclin D1 and p53 protein expression in synchronous breast carcinoma and fibrosarcoma in rats. Methods Immunohistochemical SP methods was used to study the expression of cyclin D1 and p53 in synchronous breast carcinoma and fibrosarcoma induced by DMBA in rats.Results There was no expression of cyclin D1 and p53 in normal breast tissue. In atypical hyperplasia of mammary, there was overexpression of cyclin D1(7/14) and no expression of p53. The overexpression of cyclin D1 and p53 were detected in breast carcinoma (8/18,7/18 respectively) and fibrosarcoma (9/14,5/14 respectively). There was no expression of cyclin D1 and p53 in adjacent sarcoma.The expression of cyclin D1 and p53 protein was associated with histological grading, and showed inverse relation between them. Conclusion There are cyclin D1 and p53 protein overexpression in the synchronous breast carcinoma and fibrosarcoma induced by DMBA in rats. Cyclin D1 may paticipate in the course of the carcinogenesis of breast carcinoma and fibrosarcoma in rats, and p53 protein overexpression may relate to the degree of malignancy of the tumors.

    Release date:2016-08-28 05:30 Export PDF Favorites Scan
  • 乳腺叶状囊肉瘤10例诊治体会

    Release date:2016-08-29 09:16 Export PDF Favorites Scan
  • 乳腺叶状囊肉瘤(附3例报告)

    Release date:2016-08-29 09:18 Export PDF Favorites Scan
  • The Diagnosis and Treatment of Pulmonary Arterial Hypertension Due to Rare Causes

    Objective To investigate the diagnosis and treatment of pulmonary arterial hypertension ( PAH) due to rare causes. Methods The clinical presentation, laboratory testing, diagnosis and treatment of 4 patients with PAH associated with rare causes in Beijing Anzhen Hospital from January 2001 to March 2008 were analysed retrospectively. Results Primary biliary cirrhosis, hyperthyroidism, antiphospholipid syndrome and pulmonary artery sarcoma may cause PAH, which were improved after corresponding diagnosis and management. Conclusion PAH can result from rare causes. The enhancement of its recognition will help earlier diagnosis and treatment and improve the prognosis.

    Release date:2016-09-14 11:22 Export PDF Favorites Scan
  • 原发性肺动脉肉瘤一例

    病历摘要 患者男性,65 岁。因发热伴咳嗽、气短8 d就诊。患“高血压病”4 年, 平素口服降压药, 血压控制良好。入院体检: 体温38. 4 ℃, 呼吸22 次/min, 脉搏102 次/min,血压109 /72 mm Hg( 1 mm Hg =0. 133 kPa) , 口唇无发绀, 浅表淋巴结无肿大。颈静脉无怒张, 左下肺叩诊浊音, 余肺叩清音; 两肺呼吸音粗, 左下肺呼吸音减弱, 可闻及少量湿啰音。心界向左扩大, 胸骨左缘第3 肋间可及全收缩期隆隆样杂音3/6 级, 无心包摩擦音。腹平软, 无压痛, 未及包块, 肝脾肋下未及。双下肢无肿胀。

    Release date:2016-08-30 11:53 Export PDF Favorites Scan
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