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find Keyword "肌肉注射" 3 results
  • AN EXPERIMENTAL STUDY ON PERIPHERAL NERVE REGENERATION BY CELL-ASSOCIATED THERAPY

    Objective To explore the facilitative effects of different allogenic cells injected into the denervated muscles on the nerve regeneration, the protection of the myoceptor degeneration, and the promotion for rehabilitation of the muscular function. Methods Schwann cells, myoblast cells, and renal endothelial cells were prepared from 400 SD rats aged 7 days and weighing 20.0±2.3 g. Thirty-six adult female SD rats weighing 120-150 g were randomly divided into 4 groups(n=9). Under the asepsis condition, the left ischiadic nerves of all the SD rats were cut off, and the primary suture of the epineurium was performed. After operation, the different corresponding cells were injected into the triceps muscles of the rat calf in each group once per week for 4 times in all. One ml of Schwann cells (1×106/ml) was injected into the rats in Group A; 1 ml of the mixed cells of Schwann cells and myoblast cells (1×106/ml) was injected into the rats in Group B; 1 ml of the extract from the mixed cells of Schwann cells, myoblast cells, and renal endothelial cells (1×106/ml) was injected into the rats in Group C; 1 ml of the culture medium without any serum was injected into the rats in Group D as a control. After operation, observation was made for the general condition of the rats; 3 months after operation, enzymohistochemistry and the CJun expression were performedin the ventricornual motor neuron. At the proximal and the distal ends of the nerve suture, the density of neurilemma cells in the unit area and the area size of the regenerated nerve fibers were observed and measured. Results The affected limbs of the rats in Groups A, B and C improved 13 months after operation. The ulcers and swelling at the ankles gradually relieved and the rats could move normally 3 months after operation. However, the affected limbsof the rats in Group D still had ulcers and swelling, with an obvious contracture of the toes and a difficult movement. Three months after operation, the number of the target muscle myoceptor, the number of the Actin positive cells, the activity of the various enzymes in the denervated muscles, and the histological changes of the regenerated nerves were better in Group C than in Groups A and B (P<0.01); and they were all better in Groups A, B and C than in Group D(Plt;0.01). Conclusion Schwann cells, the mixture of Schwann cells and myoblast cells, and the extract from the mixture of Schwann cells, myoblast cells and renal endothelial cells can all promote neurotization and rehabilitation of the muscular function, and protect against the myoceptor degeneration. However, the effect of the extract is superior to that of Schwann cells or the mixed cells.

    Release date:2016-09-01 09:23 Export PDF Favorites Scan
  • 不同排气方式对肝癌患者醋酸兰瑞肽肌肉注射成功率的比较

    【摘要】 目的 总结不同排气方式对肝癌患者醋酸兰瑞肽肌肉注射成功率的关系,选择最佳的排气方法。 方法 2006年11月-2009年9月,将需行醋酸兰瑞肽肌肉注射的肝癌患者182例随机分为两组,常规法92例,改良法90例。两组均用药物自带的注射用水稀释粉剂,溶解药液备用,消毒皮肤后抽吸药液,常规法排气至针乳头后,更换针头后将针头内空气排尽行肌肉注射;改良法将药液抽取在针筒,暂不排气,更换针头后快速排气至针头行肌肉注射。比较两种方法的一次肌肉注射成功率。 结果 改良法成功率明显高于常规法。 结论 将抽吸药液保留于针筒,更换针头后快速而连续排气,能提高醋酸兰瑞肽肌肉注射成功率。

    Release date:2016-09-08 09:51 Export PDF Favorites Scan
  • 心理干预对注射长效青霉素疼痛的影响

    目的探讨心理干预对注射长效青霉素疼痛的影响。 方法选取2012年1月-8月100例肌肉注射长效青霉素的患者,随机分成对照组和试验组,每组各50例。对照组采用常规注射法,干预组在常规注射基础上采用心理干预予以辅助,比较两组疼痛程度和一次性注射成功率。 结果干预组视觉模拟疼痛评分为0~2、3~5、6~8、>8分的患者分别为22、15、8、5例,对照组分别为5、18、12、15例,干预组疼痛程度轻于对照组,差异有统计学意义(Z=-3.867,P<0.001);干预组一次性注射成功率(70.0%)高于对照组(40.0%),差异有统计学意义(χ2=9.091,P=0.003)。 结论心理干预能有效降低患者疼痛程度,且一次性注射成功率高,值得推广。

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