OBJECTIVE: To observe the curative effects of basic fibroblast growth factor (bFGF) on anus wound healing. METHODS: From April 1996 to December 2000, out of 109 patients with anus trauma, hemorrhoidectomy or fistula resection, 68 were treated with bFGF as the experimental group, while 41 were treated routinely as the control group. The healing of the wound, the general and local reaction were observed. RESULTS: The healing time of the experimental group was(17.00 +/- 1.54) days while that of the control group was(20.00 +/- 1.16) days (P lt; 0.01). Three weeks after operation, the healing rates of the experimental and control groups were 97.1% and 87.8%, respectively (P lt; 0.01). No general or local detrimental reactions were found in two groups. CONCLUSION: Local application of bFGF can accelerate the healing of anus wound, and the patients have little pain.
目的 探讨保留括约肌虚挂线法治疗高位肛周脓肿的临床疗效。 方法 2009年10月-2010年10月采用随机对照试验,对52例高位肛周脓肿患者施行手术治疗,其中保留括约肌虚挂线法(治疗组)26例,切开挂线引流法(对照组)26例。对两组患者术后6个月肛瘘发生率、切口愈合时间、术后1~15 d每晚疼痛视觉模拟评分(VAS)和术后6个月痊愈患者肛门功能后遗症发生率进行比较。 结果 术后6个月,治疗组和对照组肛瘘发生率分别为4.0%和3.8%,差异无统计学意义(P>0.05)。术后7~15 d治疗组VAS评分均低于对照组,差异有统计学意义(P<0.05)。两组切口愈合时间分别为(19.05 ± 6.71)d和(21.42 ± 8.40)d,差异有统计学意义(P<0.05)。术后6个月治疗组痊愈患者肛门功能全部正常,对照组后遗症发生率为12.0%,两组比较差异有统计学意义(P<0.05)。 结论 保留括约肌虚挂线治疗在术后疼痛、切口愈合时间和保护肛门功能等方面明显优于切开挂线引流治疗,是一种治疗高位肛周脓肿较为理想的方法。
目的 探讨一期后位切开挂线左右侧切开引流手术治疗高位马蹄型肛周脓肿的临床效果。方法 前瞻性纳入2008年10月至2010年10月期间庆阳市人民医院收治的60例高位马蹄型肛周脓肿患者,将其随机分成2组,其中观察组30例,行一期后位切开挂线左右侧切开引流术;对照组30例,行一期切开挂线术。比较2组患者的临床疗效。结果 临床疗效观察组为优11例(36.67%),良17例(56.66%),差2例(6.67%),优良率为93.33%(28/30);对照组为优5例(16.67%),良16例(53.33%),差9例(30.00%),优良率为70.00%(21/30)。观察组的临床疗效优于对照组(P<0.05)。观察组患者术后肛缘水肿、肛门前移和肛门内陷的发生率以及创面愈合时间均低于或短于对照组(P<0.05)。2组患者术后均获访1年,均无复发,肛门功能均正常,无畸形。结论 一期后位切开挂线左右侧切开引流术治疗高位马蹄型肛周脓肿的临床疗效确切,患者术后恢复良好,值得临床推广应用。
目的 观察AQUACEL-Ag®亲水性纤维敷料对肛周脓肿患者术后创面愈合的作用。方法 将49例肛周脓肿术后患者按随机数字表法随机分为试验组(25例)和对照组(24例),分别予AQUACEL-Ag®亲水性纤维敷料换药(1 次/3d)和无菌凡士林纱布换药(1次/d),并观察2组患者的换药时创面疼痛程度、创面愈合时间、创面换药次数、创面愈合率及换药时创面分泌物培养结果。结果 试验组在创面疼痛、愈合时间、创面换药次数及换药时分泌物培养转阴时间方面均优于对照组(P<0.05);动态监测创面愈合率:第3d时2组间比较差异无统计学意义(P>0.05),第9、15、21d时试验组创面愈合率明显高于对照组(P<0.05)。结论 从本组有限的数据看,AQUACEL-Ag®亲水性纤维敷料对肛周脓肿患者术后创面愈合有重要作用。
Objective To investigate the early diagnosis and effective treatment of Fournier syndrome. Methods The clinical data of 385 patients with perianal abscess in this hospital between 2006 and 2009 were retrospectively analyzed for screening the patients with complication of Fournier syndrome. Results Fournier syndrome was detected in 6 patients (1.56%), who were all cured by treating with early incision and drainage, complete debridement, effective antibiotics, and supporting therapy. Conclusions Perianal abscess can induce Fournier syndrome of perineal, genital, and abdominal wall regions, which spreads rapidly and progressively, so early diagnosis and extensive surgical debridement play a decisive role on the prognosis.