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Diagnosis and Surgical Therapy of Intestinal Obstruction Caused by Colon Carcinoma in Gerontism Patient

目的 为进一步探讨老年急性结肠癌性肠梗阻的诊断及外科治疗方法，总结经验教训。方法 对我院1993~2005年收治的38例老年急性结肠癌性肠梗阻患者的临床资料进行回顾性分析。结果 38例老年急性结肠癌性肠梗阻患者，手术行一期切除吻合23例，肿瘤姑息性切除4例，单纯结肠双腔造口2例，Hartmann手术9例。术后发生并发症6例，其中切口感染5例，经换药愈合； 发生吻合口漏1例，最终死于腹腔感染、多器官功能衰竭。其余32例术后恢复良好。结论 提高对老年急性结肠癌性肠梗阻的认识，选择合理术式，加强围手术期处理，是减少手术并发症的发生、降低死亡率的重要措施。

Diagnosis and Treatment of Acute Colonic Pseudo-Obstruction （Report of 24 Cases ）

【摘要】 目的 探讨急性假性结肠梗阻的临床诊断与治疗。方法 回顾性分析24例急性假性结肠梗阻患者的临床资料。结果 24例患者均有机械性肠梗阻的临床表现。12例经保守治疗治愈； 6例经结肠镜结合中西医药物治疗治愈； 6例行手术治疗，其中4例因误诊为器质性结肠梗阻而手术，2例死亡。结论 要提高对急性假性结肠梗阻的认识，多数急性假性结肠梗阻可通过非手术方法治愈，在采取积极保守治疗的同时，通过临床仔细分析可与器质性结肠梗阻相鉴别，要严密观察患者腹部体征，防止肠穿孔等并发症的发生。

简易Feloy’S尿管行肠排列外固定术治疗复发性粘连性肠梗阻3例体会

The Management of Left Colon Carcinoma Obstruction

Objective To investigate the surgical techniques for management of left colon carcinoma obstruction. MethodsThe techniques used in left colon carcinoma obstruction and the corresponding efficiencies reported in foreign literatures were reviewed. ResultsThe surgical techniques for management of left colon carcinoma obstruction involve palliative operation, staged operation and onestage operation. These methods had their own virtues as well as shortages. But on all accounts, onestage operation was favorable for both the patients and docters. ConclusionDifferent methods for management of left colon carcinoma obstruction have different adaptation index, first you must ensure safety, then you should try your best to do onestage operation.

Prediction model of surgical treatment selection for acute adhesive small intestinal obstruction

ObjectiveTo explore the risk factors affecting operation treatment selection of acute adhesive small bowel obstruction (ASBO), and establish a prediction model of surgical treatment selection to provide a guidance for clinical decision-making. MethodsThe patients with acute ASBO admitted to this hospital and met the inclusion and exclusion criteria, from January 2019 to December 2022, were retrospectively collected, and the patients were assigned into the surgical treatment and conservative treatment according to the treatment selection. The differences in the clinicopathologic factors between the patients with surgical treatment and conservative treatment were compared. Meanwhile, the factors with statistical differences (P<0.05) or the factors with clinical significance judged based on professional knowledge were included to screen the influencing factors of surgical treatment selection using the multivariate logistic regression analysis, and the selected influencing factors were used to construct the logistic regression prediction model equation. The area under the receiver operating characteristic curve (AUC) and its 95% confidence interval (95%CI) was used to evaluate the prediction efficiency of the prediction model equation. ResultsA total of 231 patients with acute ASBO were included, 117 (50.6%) of whom underwent surgical treatment and 114 (49.4%) underwent conservative treatment. In all 16 clinicopathologic factors between the patients with surgical treatment and conservative treatment had statistical differences (P<0.05) including the body mass index (BMI), preopeative high fever, intestinal type, sign of peritonitis, acute physiology and chronic health evaluation Ⅱ (APACHE Ⅱ) score excluded age scoring, abdominal surgery history and times of abdominal surgery history, times of pre-admission seek medical advice and preoperative conservative treatment time, the air-liquid level by X-ray plain film, and severe small bowel obstruction and adhesive bands by CT examination, as well as the white blood cell count (WBC), neutrophil percentage, albumin (ALB), and urea nitrogen. The multivariate logistic regression analysis showed that the acute ASBO accompanied by sign of peritonitis (β=1.778, P=0.028), history of abdominal surgery (β=1.394, P=0.022), and adhesive bands (β=1.321, P=0.010) and severe small bowel obstruction (β=1.183, P=0.018) by CT examination, WBC (β=0.524, P＜0.001), APACHEⅡ score excluded age scoring (β=0.291, P＜0.001), and BMI (β=0.191, P=0.011) had positive impacts on adopting surgical treatment, while preoperative ALB (β=–0.101, P=0.023) and conservative treatment time (β=–0.391, P＜0.001) had negative impacts on adopting surgical treatment. The accuracy, specificity, and sensitivity of the logistic regression prediction model equation constructed according to these 9 influencing factors were 84.8%, 71.1%, and 77.7%, respectively. The AUC (95%CI) of the prediction model equation to distinguish selection of surgical treatment from conservative treatment was 0.942 (0.914, 0.970). ConclusionsAccording to the preliminary results of this study, surgical treatment is recommended for patients with acute ASBO accompanied by signs of peritonitis, history of abdominal surgery, adhesive bands and severe small bowel obstruction by CT, increased preoperative WBC, high APACHEⅡ score excluded age scoring, high BMI, preoperative low ALB level, and shorter preoperative conservative treatment time. And the logistic prediction model equation constructed according to these characteristics in this study has a good discrimination for patients with surgical treatment or conservative treatment selection.

THE EFFECTS OF DRAINAGE THROUGH ANUS ON ENDOTOXIN AND TUMOR NECROSIS FACTOR AFTER ONE STAGE RESECTION FOR LEFT OBSTRUCTING COLONIC CARCINOMAS

目的 确定不同的经肛引流方式对左半结肠癌患者一期术后外周血浆内毒素(ET)及肿瘤坏死因子(TNF)水平的影响。 方法左半结肠癌伴梗阻患者按术后经肛引流方法不同分为扩肛组(A)、经肛吻合口上单管引流组(B)及经肛吻合口上下双管引流组(C)3个组，观察各组患者一期术后ET及TNF的变化。 结果 术后A、B、C 3组ET及TNF水平均呈下降趋势，与术前比较差异有显著性意义(P＜0.01)。自术后第4天，C组患者ET及TNF水平开始显著低于B组(P＜0.05)。结论 左半结肠癌性梗阻患者一期手术行经肛引流能更有效地减少内毒素的吸收，降低TNF水平，而经肛双管引流法引流效果又优于经肛单管引流法。

Effect of Early Application of Traditional Chinese Medicine in Treating Severe Acute Pancreatitis with Paralytic Intestinal Obstruction by Retention Enema Catharsis

目的：观察柴芩承气汤治疗重症急性胰腺炎(SAP)并发麻痹性肠梗阻 (Paralytic Intestinal Obstruction)的疗效。方法:依据纳入和排除标准,选取四川大学华西医院中西医结合科收治的SAP患者40例,按1∶1比例随机分成试验组(20例)和对照组(20例),试验组入院时即给予柴芩承气汤灌肠治疗,对照组使用安慰剂灌肠治疗;两组入院时基线资料差异无统计学意义(Pgt;005)，且两组均给予相同常规西医治疗。观察入院后其首次自行排便排气时间,入院时、入院后第3天、第7天APACHEⅡ评分及住院病程。结果:入院后首次自行排便排气时间试验组（302±154）天,低于对照组（453±241）天;入院后第3天APACHEⅡ评分试验组（925±184）分，低于对照组（1163±222）分;入院后第7天APACHEⅡ评分试验组（624±247）分，低于对照组（881±325）分。住院时间试验组（2453±426）天,低于对照组（3032±589）天。结论:早期应用柴芩承气汤灌肠治疗SAP并发麻痹性肠梗阻,可缩短麻痹性肠梗阻的持续时间及减轻其危害,减少住院病程。

Study of Depression and Anxiety in Patients with Postoperative Inflammatory Small Bowel Obstruction

ObjectiveTo investigate the situation of depression and anxiety in the patients with postoperative inflammatory small bowel obstruction (PISBO), and to provide the dependent indications for the treatment. MethodsThe serf-rating depression scale (SDS scale) and self-rating anxiety scale (SAS scale) were used to test the depression and anxiety of 79 patients with PISBO, who treated in the Department of General Surgery of The Second Hospital of Lanzhou from Jan. 2008 to Oct. 2014. Comparison between the scores of SDS scale/SAS scale and corresponding Chinese norms was performed, and then exploring the influence factor of depression and anxiety of PISBO patients. ResultsThe standard scores of depression and anxiety were 49.23±11.39 and 50.31±6.25 respectively, which were higher than those of corresponding Chinese norms (P < 0.05). The results of multivariate logistic regression analysis indicated that, the independent influential factors of depression and anxiety in patients with PISBO included course of disease, type of tumor, other postoperative complications, and postoperative insomnia (P < 0.05), patients whose course of disease longer than 15 days, who with malignant tumor, and who suffered from other postoperative complications and postoperative insomnia, had higher ratios of depression and anxiety. ConclusionThe depression and anxiety is very evident in the patients with PISBO, we should pay attention to this phenomenon and give intervention for it.

Shape Memory Alloy Stent for Intestinal Obstruction Due to Rectal Cancer

Objective To evaluate initial experience with shape memory alloy stent as an alterative to colostomy in patients with intestinal obstruction of rectal cancer. Methods Twenty-one patients with acute and chronic rectal obstructions from malignant causes underwent stent placement. After rectal stent was slenderized in ice water, it was inserted into the strictured rectum by hand or sigmoidoscope. Nitinol mesh stent were deployed in hot water. Results Eighteen patients who had underwent rectal stent placement achieved clinical decompression within 5 hours. Colostomy underwent in 3 patients due to stent failure. Eighteen patients with stent were followed-up, 14 cases died in 56-720 days and 4 other cases were still alive without intestinal obstruction in 2-15 months. Conclusion Nitinol mesh stent may be useful in the management of terminal or high-risk surgical patients for palliative purposes shuning colostomy. Palliation of stent combined with chemotherapy and immunotherapy can be performed to improve survival.

THE DIAGNOSIS AND TREATMENT OF EARLY POSTOPERATIVE INFLAMMATORY SMALL BOWEL OBSTRUCTION (REPORT OF 16 CASES)

目的 探讨术后早期炎症性肠梗阻的诊断和治疗。方法 对我院1995年至1999年间收治的16例术后早期炎症性肠梗阻患者的临床资料进行回顾性分析。结果 15例患者经胃肠减压、抗生素、理疗、肾上腺皮质激素及中药等治疗治愈，平均治疗时间11天； 中转手术治疗1例，无1例肠坏死。结论 术后早期炎症性肠梗阻的特点有： ①多在手术后7天左右出现梗阻症状，多由腹腔内炎症所致广泛粘连引起； ②症状以腹胀为主，腹痛相对较轻，较少发生肠绞窄； ③治疗应首选非手术疗法。