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find Keyword "胆囊胆固醇结石" 3 results
  • Research Status of Female Hormone in Cholesterol Gallstones

    Objective To review the mechanisms of cholesterol gallstones caused by female hormone so as to explore new treatments to prevent gallstones associated with estrogen and progesterone. Methods The literatures on gallstones related with female hormone were reviewed and the mechanisms of cholesterol gallstones were summarized. Results The cholesterol gallstones mechanisms was affected by estrogen through genomic effects,and the nucleation of cholesterol was promoted by estrogen through nongenomic,which resulted in the formation of cholesterol gallstones. And the bile empty dysfunction associated with estrogen through nongenomic effects was also the reason of cholesterol gallstone formation. The G proteins α subunit responsible for the motility of gallbladder were disrupted by progesterone through genomic effects,and the ionic channels and signal transduction were also interfered through nongenomic pathway,which impaired the contraction of gallbladder. However,the nongenomic effects might not play an important role in the gallstones formation caused by progesterone. Conclusions The mechanisms of cholesterol gallstones formation associated with female hormone are complicated,the understanding of chelesterol gallstones formation mechanisms might be helpful to prevent gallstones associated with estrogen and progesterone.

    Release date:2016-09-08 10:38 Export PDF Favorites Scan
  • Study on the Relationship Between STHZMDR1 Gene Expression in Liver Cell and Cholesterol Calculus in Gallbladder

    【Abstract】Objective To explore the relationship between the expression of MDR1 gene in liver cell and the formation of cholesterol calculus in gallbladder.Methods The mRNA expression level of MDR1 gene in liver cell of the cholesterol calculus group and the normal control group were measured through reverse transcriptionpolymerase chain reaction (RT-PCR), and microglobulin β2 was used as internal contrast.Results The MDR1 mRNA expression level of the cholesterol calculus group was lower than that of the normal control group(1.30±0.19 vs 2.25±0.28, P<0.01). Conclusion The formation of cholesterol calculus in gallbladder is related to the reducd expression level of MDR1 gene in liver cell.

    Release date:2016-09-08 11:54 Export PDF Favorites Scan
  • NHE3在胆固醇结石胆囊组织中的表达

    目的研究NHE3在正常和胆固醇结石患者胆囊黏膜上皮细胞中的表达情况,并探讨NHE3表达异常与结石形成的关系 方法利用Western blot以及免疫组织化学方法检测10例正常与16例胆固醇结石患者胆囊黏膜上皮细胞中NHE3蛋白和亚细胞定位的表达情况。 结果Western blot和免疫组织化学染色方法均显示,与正常胆囊组相比,结石组胆囊黏膜上皮细胞中NHE3表达增高(P<0.05),NHE3同时表达于胆囊黏膜上皮细胞的顶质膜和胞浆内。 结论NHE3表达异常可能与胆囊胆固醇结石发病相关,其发生机理有待进一步研究证实。

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