Objective To review the research progress of electrospun nanofibers scaffold in nerve tissue engineering. Methods The related l iterature on electrospun nanofibers scaffold in nerve tissue engineering was extensively reviewed and analyzed. Results A variety of material nanofibers scaffolds can be fabricated through electrospinning. The chemical and physical properties of the scaffold can be modified and it was suitable for neuron. The scaffold can bridge the defect of peripheral nerve and partial function can be restored. Conclusion Electrospun nanofibers scaffold has broad appl ication prospects in nerve tissue engineering.