west china medical publishers
Author
  • Title
  • Author
  • Keyword
  • Abstract
Advance search
Advance search

Search

find Author "胡绳" 2 results
  • 地震吸入性肺炎的诊治经验

    地震导致的房屋垮塌、山体滑坡、泥石流,一般伴随有大量泥土粉尘形成。处于此类环境中的人员,可以在短期内吸人大量的粉尘,形成急性吸人性肺炎,所产生的病理变化与长期井下作业的慢性粉尘吸人不同。我们收治了1例颅脑外伤合并吸人性肺炎地震伤员,其吸人性肺炎改变与经典定义的吸人性肺炎有一些差异。现整理、分析如下,以期引起对地震吸人性肺炎的诊治情况的注意。

    Release date:2016-09-14 11:56 Export PDF Favorites Scan
  • Effect of hypoxic preconditioning on rat lungs exposed to simulated high altitude hypoxia

    Objective To investigate the influence of hypoxic preconditioning on pulmonary structure of rats exposed to simulated high altitude hypoxia and to explore the role of hypoxia inducible factor-1α(HIF-1α).Methods Fifty-six Wistar rats were randomly divided into 7 groups(n=8 in each group),ie,a normal control group(N group),an acute hypoxic control group(H0 group),an acute hypoxic group(H1 group),a 3 000 m hypoxic preconditioning group(C3.0 group),a 3 000 m hypoxic preconditioning + acute hypoxic group (C3.1 group),a 5 000 m hypoxic preconditioning group(C5.0 group),and a 5 000 m hypoxic preconditioning + acute hypoxic group(C5.1 group).After treated with hypoxic preconditioning,the animals were exposed to simulated altitude of 6 000 m for 24 hours.Then the protein and mRNA expression of HIF-1α in lung of N,H0,C3.0 and C5.0 groups were assessed by Western blot and RT-PCR,respectively.The lung structure in N,H1,C3.1 and C5.1 groups was observed by light microscope and electron microscope.Results Pulmonary interstitial edema was apparently observed in H1 group,while significantly relieved in two hypoxic preconditioning groups.HIF-1α protein was not detected in rat lungs by Western blot analysis.Compared to N group,the levels of HIF-1α mRNA significantly increased in C3.0 group and C5.0 group(both Plt;0.01).Conclusions Hypoxic preconditioning can relieve hypoxic pulmonary interstitial edema and increase HIF-1α mRNA expression in rat lungs.HIF-1 may be involved in the process of hypoxic preconditioning in rat lungs.

    Release date:2016-09-14 11:56 Export PDF Favorites Scan
1 pages Previous 1 Next

Format

Content