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find Keyword "胰岛素样生长因子-1受体" 2 results
  • 心肌梗死后残存心肌细胞肥大性改变及其IGF1、IGF1R的表达

    目的 观察心肌梗死后残存心肌细胞肥大性改变及其胰岛素样生长因子-1(IGF-1)、胰岛素样生长因子-1受体(IGF-1R)的表达,探讨梗死心肌心肌细胞肥大的机制。 方法 取急性心肌梗死后2周、4周、8周的梗死心肌,制备单心肌细胞悬液,采用激光共聚焦扫描显微镜(Confocal)检测心肌细胞体积,采用免疫组织化学法检测心肌细胞IGF-1、IGF-1R的表达。 结果 〖HTSS〗急性心肌梗死8周梗死区域心肌细胞体积较正常区域心肌细胞增大(37 563.93±6 176.79 μm3 vs. 28 638.61±6 890.89 μm3, t=4.840,P=0.020),细胞肥大以宽度和厚度为主;梗死区域心肌细胞可见IGF1染色阳性颗粒,IGF-1表达高于正常区域心肌细胞(79.58±4.57 vs. 64.12±3.91,t=27.564,P=0.002);IGF-1R主要分布于心肌细胞膜,梗死区域心肌细胞IGF1R表达高于正常区域心肌细胞(67.02±2.56 vs. 66.73±3.49,t=3.845,P=0.042),其中以急性心肌梗死4周IGF-1R表达最高。 结论 心肌梗死后残存心肌细胞分泌IGF-1和IGF-1R,并可能在促使残存心肌细胞肥大中起了积极作用。

    Release date:2016-08-30 05:59 Export PDF Favorites Scan
  • Influence of Neoadjuvant Chemotherapy on Insulin-Like Growth Factor-1 Receptor Expression of Breast Cancer Patients

    Objective To investigate the impacts of neoadjuvant chemotherapy on the expression of insulin-like growth factor-1 receptor (IGF-1R) and on operation procedure and the significance of prognosis. Methods The expression of IGF-1R in 40 patients with breast cancer before and after neoadjuvant chemotherapy was measured by immunohistochemistry. The diagnosis was proved by core biopsy. All the patients took the TAC chemotherapy regimen. Modified radical operation was performed after two chemotherapy cycles and the IGF-1R expression was measured again. The clinical effect of neoadjuvant chemotherapy was assessed according to WHO criterion by measuring the size of tumor by physical examination and B type ultrasound. Results After neoadjuvant chemotherapy the tumor size shrank in 29 patients, there was no CR (complete response) or PD (progressed disease) to be documented. IGF-1R expression could be downregulated in 25 patients. Conclusion Neoadjuvant chemotherapy can inhibit the tumor growth by downregulation of the expression of IGF-1R.

    Release date:2016-09-08 10:56 Export PDF Favorites Scan
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