Objective To explore the relationship between the structure and function of galectin-3, lipid metabolism disorders, and investigate the expression of galectin-3 in the occurrence and progress of lower limb arteriosclerosis block disease. Methods Related articles were reviewed. Results Galectin-3 participates in inflammatory reaction and lipid metabolism disorders, regulates the cell growth, differentiation, adhesion, apoptosis, and angiogenesis, and palys a role in the occurrence and progress of arteriosclerosis obliterans. Conclusion Galectin-3 is correlation with the occurrence, progress, and the prognosis of arteriosclerosis obliterans.