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静脉再次注射荧光素钠致腹痛一例

荧光素钠静脉注射后的二次过敏反应

报告3例十分少见的荧光素钠静脉注射后引起的二次过敏反应。分别表现为晕厥、腹痛、腹泻或似癫痫样发作。文中对引起过敏反应的可能机理进行了探讨，并提出对过敏患者进行观察随访的必要性。 （中华眼底病杂志，1994，10：186-187）

实时荧光显像在胶质瘤术中应用的研究进展

【摘要】胶质瘤是中枢神经系统发病率最高的恶性肿瘤，目前的治疗方法是以手术为主、放化疗为辅的分级分型个体化综合治疗，其中手术为最快速和有效去除肿瘤组织的手段。由于肿瘤常呈浸润性生长，术中肿瘤边界显示不清，要达到术中全切非常困难。提高肿瘤边界判断的准确性，以助于术者最大限度地切除肿瘤，便成为改善患者预后的主要方法。术中实时荧光显像技术为近年来蓬勃发展的判断肿瘤边界的新技术。目前国际上荧光显像方法主要有δ-氨基-γ-酮戊酸、荧光素钠、纳米荧光探针、靛氰绿、多光子激发荧光等引导的荧光显像法，前两者相对较成熟而后三者仍处于研究之中。本文就术中实时荧光显像在胶质瘤术中应用进行阐述。

Optical coherence tomography angiography and traditional multimodal fundus imaging in the diagnosis and activity evaluation of choroidal neovascularization in exudative age-related macular degeneration

Objective To compare the consistency and difference of optical coherence tomography angiography (OCTA) and traditional multimodal fundus imaging in the diagnosis and activity evaluation of choroidal neovascularization (CNV) in exudative age-related macular degeneration (AMD). Methods A total of 112 exudative AMD patients (130 eyes) were included in this retrospective study, 62 were men (71 eyes) and 50 were women (59 eyes). The mean age was (68.250±9.789) years (range 50 – 91 years). All patients were underwent traditional multimodal fundus imaging including fundus fluorescein angiography (FFA), indocyanine green angiography (ICGA) and spectral domain optical coherence tomography (OCT); OCTA was performed at the same time. The CNV type was divided into active and non-active according to the results of traditional multimodal fundus imaging. The vascular pattern was divided into active and non-active according to the results of OCTA. Using traditional multimodal fundus imaging as the standard, the sensitivity and specialty of OCTA was evaluated. Results In 130 eyes, CNV was visualized on traditional multimodal fundus imaging in 109 eyes (83.8%); CNV was visualized on OCTA in 103 eyes (79.2%), which including 7 eyes of false negative and 1 eye of false positive. The sensitivity of OCTA for CNV diagnosis was 93.6%, with specificity of 95.2%. The CNV detection rate between two methods had no significant difference (Youden index=0.89,Kappa value=0.796,P=0.07). In 109 eyes diagnosed with CNV by traditional multimodal fundus imaging, 73 eyes (67.0%) were active CNV and 36 eyes (33.0%) were non-active CNV; the vascular pattern was active in 60 eyes (55.0%) and non-active in 49 eyes (45.0%). The sensitivity of OCTA for the detection of active CNV was 82.2%, with specificity of 100.0%. The active CNV detection rate between two methods had no significant difference (Youden index=0.82,Kappa value=0.753,P=0.00). Conclusion In the diagnosis and activity evaluation of CNV in exudative AMD, there is remarkable consistency between OCTA and traditional multimodal fundus imaging.