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find Author "蔡琳" 20 results
  • Effectiveness and Safety of Safflor Yellow for Unstable Angina: A Systematic Review

    Objective To systematically review the effectiveness and safety of safflor yellow for unstable angina. Methods Relevant studies of safflor yellow for unstable angina were collected from databases including CENTRAL (Issue 4, 2012), MEDLINE, EMbase, CNKI, VIP, WanFang Data and CBM from January, 2007 to December, 2012. Two reviewers independently screened literature according to the inclusion and exclusion criteria, extracted data and assessed the quality of the included studies. Then, meta-analysis was performed using RevMan 5.1 software. Results A total of 6 RCTs involving 533 patients were included, which were of low quality. The results of meta-analysis showed: compared with conventional treatment alone, safflor yellow plus routine biomedical treatment significantly improved the symptoms f angina (excellence: OR=2.34, 95%CI 1.79 to 4.87; effectiveness: OR=1.23, 95%CI 0.86 to 1.76). Besides, it significantly improved ECG outcomes (excellence: OR=1.85, 95%CI 1.29 to 2.64; effectiveness: OR=1.43, 95%CI 1.00 to 2.05), obviously improved the hemorheology index and blood lipid, reduced plasma homocysteine concentration, and increased the decreasing of nitroglycerin stop amount. No damage of the liver and kidney were reported. Conclusion Current evidence showed that, safflor yellow plus routine biomedical treatment is effective in the treatment of unstable angina, which is superior to routine biomedical treatment alone. Due to the limited quantity and quality of the included studies, more high quality, double blind, randomized controlled trials are needed to verify the above conclusion.

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  • 无痛纤维支气管镜检查围手术期护理

    目的 总结无痛纤维支气管镜检查围手术期护理要点。 方法 对2011年11月-2012年5月行无痛纤维支气管镜检查的335例患者的围手术期护理方法进行回顾分析。 结果 335例患者均顺利完成检查,仅1例出现低氧血症但无麻醉意外发生,患者平均检查时间为(12.9 ± 2.27)min。 结论 采取积极有效的围手术期护理措施,能有效降低无痛纤维支气管镜检查患者围手术期相关并发症的发生率。

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  • ICU医护人员对床旁X线摄片的防护对策

    目的 探讨ICU医护人员对床旁X线摄片的防护方法与措施。 方法 通过采取时间防护、屏蔽防护、距离防护、提高医护人员防护认知等方法,加强对床旁X线摄片的辐射进行防护。 结果 医护人员对床旁X线摄片防护措施满意度较高;年度体检中未出现与X射线不良反应有关的表现,白细胞均在正常范围。 结论 在合理、科学、正确的应用辐射技术的同时,应使之达到辐射防护的最优化,最大限度的预防和缩小电离辐射对人类的危害。

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  • Detection of Epithelial to Mesenchymal Transition in Airways of a Bleomycin Induced Pulmonary Fibrosis Model Derived From an α-Smooth Muscle Actin-Cre Transgenic Mouse

    Objective To explore whether epithelial to mesenchymal transition ( EMT) occurs in bleomycin( BLM) induced pulmonary fibrosis, and the involvement of bronchial epithelial cells( BECs) in the EMT. Methods BLM-induced peribronchial fibrosis in an α-smooth muscle actin-Cre transgenic mouse( α-SMACre /R26R) was examined by pulmonary βgal staining and α-SMA immunofluorescence staining. Results BLMtreated mice showed significantly enhanced βgal staining in subepithelial areas in bronchi, terminal bronchioles and walls of pulmonary vessels. Some alveolar epithelial cells( AECs) in certain peribronchial areas or even a small subset of BECs were also positively stained, as confirmed by α-SMA immunostaining. Conclusions EMT occurs in BLM-induced peribronchial fibrosis mice. BECs, like AECs, have the capacity to undergo EMT and to contribute to mesenchymal expansion in pulmonary fibrosis.

    Release date:2016-09-14 11:22 Export PDF Favorites Scan
  • The Expression of High Mobility Group Protein-B1 and Alpha-Smooth Muscle Actin in Lung Tissues of Pulmonary Fibrosis Mice

    Objective To investigate the expression of high mobility group protein-B1( HMGB1)and α-smooth muscle actin( α-SMA) in Bleomycin induced pulmonary fibrosis in mice. Methods Twenty C57BL/ 6 male mice were randomly divided into a Bleomycin group and a control group. The Bleomycin group was treated with Bleomycin( 3 mg/kg) by endotracheally injection to induce pulmonary fibrosis. The control group were treated with normal saline( NS) . Then they were sacrificed by abdominal aortic bleeding 10 days after the injection. The right lung was stained with hematoxylin-eosin and Masson trichrome respectively for pathological examination. Immunohistochemistry and RT-PCR were performed to identify the protein and mRNA levels of α-SMA and HMGB1 respectively. Results The mRNA( 0. 89 ±0. 12, 0. 61 ±0. 08) and protein( 13. 66 ±1. 01, 13. 12 ±1. 33) expressions of α-SMA and HMGB1 in the Bleomycin group were all significantly higher than those of the control group( mRNA: 0. 60 ±0. 07, 0. 15 ±0. 02; protein: 8. 18 ±1. 33,7. 92 ±1. 10; all P lt; 0. 01) . Conclusions The expressions of HMGB1 and α-SMA are increased in Bleomycin induced pulmonary fibrosis. HMGB1 participates in the pathological process of pulmonary fibrosis probably by activation of the α-SMA expression.

    Release date:2016-09-14 11:23 Export PDF Favorites Scan
  • Effects of Lactic Acid Bacteria on Dust Mite Induced Allergic Inflammation in Mice Involving the Regulation of MAPK Signaling

    Objective To investigate the effects and mechanisms of lactic acid bacteria on MAPK signaling in immune response of dust mite sensitized mice. Methods Forty C57BL/6 mice in Group M, P and L, were sensitized and challenged with mite extract while then the animals in Group N were treated with saline as control. The mice in Group L and P were fed with Lactococcus lactis or Lactobacillus respectively.Three days after the last challenge, all mice were sacrificed for lung pathological examination. IL-10 level in culture supernatant of splenocytes stimulated with mite extract was detected by ELISA. The expression of IL-4/ IFN-γon CD3 +CD4 + cells was detected by flow cytometry. Western blot were performed for detection of MAPK signaling ( P38, ERK, and JNK) from mice’s spleen cells stimulated with mite extract. Results The mice fed with Lactococcus lactis ( Group L) had lower rate of eosinophilic airway inflammation and higher level of IL-10 in the culture supernatant of splenocytes than Group P. Meanwhile, the number of CD4 + T cell with IL-4 expression was decreased revealed by the analysis of flow cytometry. P38 signaling inspleen cells was activated in the mice of Group M, similarly in the mice of Group P, but not of Group L.Conclusion Oral treatment of Lactococcus lactis can induce an immune tolerance in response to mite by up-regulating the level of Tr cells secreting IL-10, thus inhibiting activation of P38 signaling.

    Release date:2016-09-13 04:06 Export PDF Favorites Scan
  • 糖类抗原125与慢性阻塞性肺疾病急性加重期及右心功能关系的研究

    目的 探讨糖类抗原125(CA125)与慢性阻塞性肺疾病急性加重期(AECOPD)、右心功能临床状态关系。 方法 收集2011年3月-2012年2月住院AECOPD患者54例,根据患者临床症状及心脏超声结果将其分为3组,每组各18例。A组为单纯AECOPD,B组为AECOPD伴右心功能代偿期,C组为AECOPD伴右心功能失代偿期;另有年龄匹配的同期入院的无明显器质性病变患者18例作为对照组(D组)。入院后搜集各组患者临床基本资料,测量CA125值。 结果 A、B、C、D组CA125水平分别为(25.40 ± 12.48)、(10.22 ± 3.42)、(39.82 ± 25.70)、(91.91 ± 39.98) U/mL。与D组比较,A、B、C组的CA125水平均明显升高(P≤0.001);C组与其他组比较,CA125水平升高(P=0.000);A、B组CA125水平差异无统计学意义(P=0.168)。 结论 升高的CA125与AECOPD临床状态及其恶化有一定相关性,可能是监测慢性肺源性心脏病心功能失代偿期的有用指标。

    Release date:2016-09-07 02:34 Export PDF Favorites Scan
  • The Association between Extent and Severity of Acute Coronary Syndrome and Uric Acid, Leukocytes

    ObjectiveTo evaluate the association between extent and severity of acute coronary syndrome and uric acid, leukocytes. MethodsA retrospective analysis of leukocytes, platelets, lipids and uric acid levels were performed on 23 patients with acute myocardial infarction (AMI group), 17 patients with unstable angina (UA group), and 17 healthy subjects (controls) between January and December 2010. ResultsIn the three groups (AMI, UA, and Control), the leukocyte count was respectively (10.4±3.2)×109/L, (6.9±2.4)×109/L and (5.4±1.1)×109/L (P<0.05); neutrophil was (7.4±3.2)×109/L, (4.8±2.3)×109/L, and (3.4±0.8)×109/L (P<0.001); and uric acid was (401.4±94.3), (384.1±74.1) and (285.5±76.8) μmol/L, respectively (P<0.001). Multinomial Logistic regression showed leukocyte was a predictor for AMI (OR=1.712, P=0.003), while uric acid was not (OR=1.006, P=0.255), regarding the UA group as the reference. When the control group was using as reference, leukocyte was an independently significant factor for AMI (OR=2.942, P=0.004) and was not a significant factor for UA (OR=1.718, P=0.125); uric acid was a significant factor for AMI and UA (OR=1.027, P=0.016; OR=1.021, P=0.041). ConclusionUric acid may be associated with the chronic development of coronary heart disease, while leukocytes may play a potential role in plaque destabilization and the onset of AMI.

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  • Effects of Comprehensive Nursing Intervention to Prevent Multi-drug Resistant Infections of Patients in Intensive Care Unit

    ObjectiveTo confirm the effect of comprehensive prevention and care measures in reducing the incidence of multi-drug resistance in Intensive Care Unit (ICU) patients. MethodFrom March 1 to August 31 in 2014, we took routine measures to prevent multi-drug-resistant infections in ICU patients, and from September 1 in 2014 to February 28 in 2015, We added a series of comprehensive prevention measures to prevent multi-drug resistant infections including focus on isolation, temperature control of the ward, ward disinfection, quality improvement of basic care, standardized management and disinfection of equipments in ICU. Finally, we compared the detection rate of multi-drug resistant patients before and after the comprehensive nursing intervention. ResultsAfter taking comprehensive care interventions and a six-month monitoring, the detection rate of multi-resistant bacteria occurred in 11.87‰ of the patients. Compared with the previous six months, the detection rate dropped from 16.64‰ to 11.87‰ with a significant difference (χ2=6.346,P=0.012). ConclusionsComprehensive nursing intervention measures taken by the ICU department can effectively reduce multi-drug resistant infections in ICU patients.

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  • Application of Nasopharyngeal Airway in Obesity Patients during General Anesthesia Induction

    ObjectiveTo evaluate the superiority of nasopharyngeal airway on obesity patients during general anesthesia induction period. MethodForty-two trachea cannula and general anesthesia obesity patients treated from June to November in 2013 were chosen and divided equally into two groups:nasopharyngeal airway group (group A) and control group (group B). Mean arterial pressure (MAP), heart rate (HR), pulse oxygen saturation (SpO2), arterial blood partial pressure of carbon dioxide (PaCO2) were recorded when the patients entered the operation room, three minutes after man-made positive pressure ventilating and five minutes after intubation. Peak voltage (Ppeak) of man-made positive pressure ventilation for three minutes was also observed, and intubation frequency and time, mouth mucosa bleeding, and sore throat examples were compared between the two groups. ResultsCompared with group B, MAP, HR, PaCO2 and Ppeak three minutes after man-made positive pressure ventilating were lower (P<0.05), but SpO2 was higher in group A (P<0.05). Intubation frequency and time, mouth mucosa bleeding, and sore throat examples of group A were less than those in group B (P<0.05). ConclusionsNasopharyngeal airway is better for obesity patients during general anesthesia induction period, which also improves anesthesia safety level.

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