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find Author "薛志强" 3 results
  • Single Utility Port Complete Video-assisted Thoracoscopic Surgery Lobectomy for Patients with Early-stage Lung Cancer

    Abstract:?Objective?To evaluate clinical outcomes of single utility port complete video-assisted thoracoscopic surgery (VATS) lobectomy for patients with early-stage lung cancer.?Methods?We retrospectively analyzed the clinical data of 162 consecutive patients with early-stage lung cancer who underwent single utility port complete VATS lobectomy from September 2009 to October 2011 in Chinese PLA General Hospital (single utility port group),and compared them with 221 patients with early-stage lung cancer who underwent video-assisted mini-thoracotomy (VAMT) lobectomy in the same period (VAMT group). The clinical outcomes including operation time, intraoperative blood loss, lymph node dissection number, time to first activity out of bed, chest drainage duration and postoperative complications, were compared between the two groups.?Results?No perioperative death was observed in both groups. There were statistical differences in the intraoperative blood loss (162.8±75.6 ml vs. 231.4±62.8 ml), time to first activity out of bed (2.2±0.3 d vs. 3.7±0.5 d) , and chest drainage duration (3.5±0.2 d vs. 4.6±0.4 d) between the two groups (P<0.05). There was no statistical difference in operation time (133.7±22.0 min vs. 124.9±25.7 min) , lymph node dissection number (11.7±1.9 vs. 12.5±2.7), and incidence of serious postoperative complications (7.4% vs. 8.1%)between the two groups.?Conclusion?Single utility port complete VATS lobectomy and lymph node dissection are safe and reliable for patients with early-stage lung cancer with less injury and better postoperative recovery compared with VAMT.

    Release date:2016-08-30 05:49 Export PDF Favorites Scan
  • 胸腺瘤表皮生长因子受体、增殖细胞核抗原、Bcl-2和Bax表达及临床意义

    目的 探讨胸腺瘤表皮生长因子受体(EGFR)、增殖细胞核抗原(PCNA)、Bcl-2和Bax的表达与胸腺瘤临床病理特征的关系及临床意义. 方法 应用免疫组织化学链霉素亲生物蛋白-过氧化酶(S-P)法检测46例胸腺瘤患者EGFR、PCNA、Bcl-2和Bax的表达. 结果 胸腺瘤EGFR阳性表达率为71.7%,PCNA标记指数为4.00%±1.87%,Bcl-2、Bax阳性率分别为41.3%、15.2%.EGFR表达与胸腺瘤Masaoka分期、肿瘤性质有明显关系,EGFR阴性者术后生存率显著高于阳性者(P=0.005).PCNA标记指数和Bcl-2与胸腺瘤肿瘤性质有明显关系,Bcl-2阴性者术后生存率显著高于阳性者(P=0.002).EGFR、PCNA、Bcl-2和Bax表达均与胸腺瘤组织学类型、是否合并重症肌无力无明显关系. 结论 EGFR与胸腺瘤的发生、发展有关,可作为Masaoka分期的补充推测预后.Bcl-2与胸腺癌发生有关,可作为胸腺癌的标记物用于鉴别诊断.

    Release date:2016-08-30 06:32 Export PDF Favorites Scan
  • The Early Responses of VEGFs During Acute Lung Injury Induced by Immersion in Seawater after Open Chest Trauma

    【Abstract】Objective To investigate the role of VEGF and its soluble VEGF receptor ( sVEGFR-1) in pathogenesis of acute lung injury ( ALI) induced by immersion in seawater after open chest trauma. Methods Sixteen hybridized adult dogs were randomly divided into control group and seawater group. The control group only suffered from open chest trauma, whereas the seawater group were exposed to seawater after open chest trauma. Blood samples were collected at the 0, 2, 4, 6, 8 h after trauma for measurement of white blood cell count, arterial blood gas, plasma osmotic pressure ( POP) , electrolyte concentration, IL-8, vWF, VEGF and sVEGFR-1 levels. The lungs tissue and BALF was collected at 8 h after trauma. Pathological changes of the lung was observed under light microscope by HE staining. Meanwhile VEGF and sVEGFR-1 levels were measured in BALF and lung tissue homogenate. Total protein concentrations in plasma and BALF were measured to calculate the pulmonary penetration index ( PPI) . Results The lung of the seawater group showed interstitial mononuclear cell and neutrophil infiltration, interstitial edema, and vascular congestion. VEGF and sVEGFR-1 were significantly increased in the plasma, while VEGF was significantly reduced in the lung tissues and BALF. The levels of IL-1β, IL-8 and vWF, just as the level of VEGF, were significantly increased in the plasma. Meanwhile, the POP and electrolyte concentration were significantly increased. In the plasma, the responses of VEGFs during the early onset of ALI induced by immersion in seawater after open chest trauma were consistent with the POP and PPI. Conclusions High plasma levels and low BALF/ lung tissue levels of VEGFs is a distinguishing characteristic during the early onset of ALI induced by immersion in seawater after open chest trauma. VEGF may be a novel biomarker which has an important role in the development of ALI.

    Release date:2016-09-14 11:24 Export PDF Favorites Scan
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