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find Author "袁冬青" 2 results
  • 热休克蛋白90抑制剂治疗新生血管性眼病的研究现状

    热休克蛋白90(HSP90)作为一种广泛存在的分子伴侣,在新生血管性疾病的发生发展中起重要作用。HSP90抑制剂能抑制HSP90活性,引起与细胞增生、细胞周期调节、细胞凋亡有关的重要信号蛋白选择性降解,并通过与磷脂酰肌醇-3激酶/蛋白激酶B和类风湿性关节炎因子/蛋氨酸脑啡肽/促分裂原活化蛋白激酶等信号通路中的多种HSP90客户蛋白分子相互作用,降低血管生成因子的表达,从而抑制血管内皮细胞的增生和存活。研发特异性的HSP90抑制剂药物已经成为治疗肿瘤及相关新生血管性疾病的新选择。其可能成为治疗新生血管性眼病的全新靶点。

    Release date:2016-09-02 05:26 Export PDF Favorites Scan
  • Effect of internal limiting membrane peeling and transplantation on vision-related quality of life in refractory macular hole

    ObjectiveTo observe the effect of internal limiting membrane peeling and transplantation on vision-related quality of life in refractory macular hole.MethodsA retrospective clinical study. Thirty patients (30 eyes) with refractory macular hole diagnosed in Ophthalmology Department of The First Affiliated Hospital of Nanjing Medical University from January to December 2016 were included in this study. There were 13 males (13 eyes) and 17 females (17 eyes), with the mean age of 57.3±6.9 years. There were 15 patients (15 eyes) with large macular diameter, 12 patients (12 eyes) with high myopia macular hole, and 3 patients (3 eyes) with secondary traumatic macular hole. The BCVA examination was performed using the Snellen visual acuity chart, which was converted into logMAR visual acuity. OCT was performed to measure the macular retinal thickness (CRT), base diameter and minimum diameter of macular hole. Then, the macular hole index (MHI) was calculated. The logMAR BCVA was 1.52±0.30, MHI was 0.51±0.19. The Chinese version of visual-related quality of life scale -25 (CVRQoL-25) was used to evaluate the vision-related quality of life of patients. The CVRQoL-25 score was 57.60±7.13. All patients underwent 23G vitrectomy combined with inner limited membrane peeling and autologous ILM transplantation. The follow-up was at least 3 months after surgery. The changes of BCVA, MHI, CRT and CVRQoL-25 score before and after surgery were comparatively analyzed. Paired t test was performed to compare the measurement data before and after surgery, and Spearman rank correlation analysis was used for the correlation analysis among the parameters.ResultsAt 3 months after surgery, the hole closure was detected in 28 eyes (93.3%), not detected in 2 eyes (6.7%). The logMAR BCVA was 1.16±0.33, CRT was 161.00±15.26, and CVRQoL-25 scores was 70.83±9.77. Compared with before surgery, the BCVA (t=4.386, P=0.000) and CVRQoL-25 score (t=-5.991, P=0.000) after surgery were improved. Spearman rank correlation analysis showed that CVRQoL-25 score was negatively correlated with preoperative and postoperative logMAR BCVA (r=−0.536, −0.796; P=0.002, 0.000); positively correlated with preoperative MHI (r=0.421, P=0.020) and postoperative CRT (r=0.589, P=0.001).ConclusionInternal limiting membrane peeling and transplantation for refractory macular hole can significantly improve the vision-related quality of life and visual acuity, while achieved a high hole closure rate (93.3%).

    Release date:2020-01-11 10:26 Export PDF Favorites Scan
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