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find Author "袁维利" 2 results
  • 艾迪注射液联合化疗治疗原发性肝细胞癌系统评价

    目的:评价艾迪注射液配合肝动脉栓塞化疗(Transcatheter arterial chemoembolization TACE)或全身化疗与照单纯TACE或单纯化疗(干预Ⅰ与干预Ⅱ)治疗原发性肝细胞癌的有效性和安全性。方法:采用Cochrane系统评价方法,计算机检索MEDLINE、CENTRAL、EMBASE、CBM、CNKI、VIP和万方数据库、Cochrane图书馆临床对照试验库等;同时互联网检索正在进行的临床试验;手工检索相关期刊和附加检索相关会议论文集。对纳入的同质研究采用RevMan50进行Meta分析。结果:Meta分析结果表明:干预Ⅰ在提高近期疗效有效率、生活质量提高率、减少骨髓抑制率、提高免疫力、提高生存率等方面优于干预Ⅱ,差异有统计学意义。但艾迪注射液联合全身化疗在提高近期疗效有效率方面无统计学意义。结论:艾迪注射液对原发性肝癌有一定的治疗作用,但由于纳入试验的方法学质量普遍较低,期待更多设计合理、严格执行的大样本随机双盲对照试验提供高质量的证据。

    Release date:2016-08-26 02:21 Export PDF Favorites Scan
  • Protective Effects of Decoction Plus Radiotherapy on Nasopharyngeal Carcinoma: A Meta-analysis of Randomized Controlled Trials

    【摘要】 目的 评价中药复方(益气养阴、清热活血方Yiqi Yangyin Qingre Huoxue decoction,YYQHD)联合放射疗法治疗鼻咽癌在减毒增效方面的疗效。 方法 采用Cochrane系统评价方法,电子检索Cochrane图书馆临床对照试验资料库(Cochrane Central Register of Controlled Trials,CENTRAL)、PubMed、EMBASE、中国生物医学文献数据库(CBM)、中文科技期刊全文数据库(CNKI)和中国期刊全文数据库(VIP)以及万方数据库等数据库2010年3月前所发表的相关文献。同时互联网检索Current Controlled Trial、Clinical Trials和中国临床试验注册网。手工检索部分肿瘤类核心期刊。采用Cochrane协作网推荐的 “偏倚风险评估”工具,评估纳入研究的质量,使用RevMan 5.0.23.0软件对纳入的研究进行定量系统评价。 结果 最终纳入符合标准的中文文献9篇共795例患者。定量分析结果显示:与单纯常规放射治疗相比较,中药复方(YYQHD)联合常规放射治疗能显著提高肿瘤近期疗效、生存率,并且能显著减少放射治疗常见毒副反应的发生,从而提高放射治疗按时完成率确保放射治疗疗效、改善患者生存质量。 结论 虽现有研究尚不能得出可以将中药复方(YYQHD)作为标准治疗手段辅助放射治疗的结论,但提示益气养阴、清热活血类中药联合放射治疗治疗鼻咽癌是值得继续探索的研究方向,期待设计科学合理、高质量的多中心、大样本、双盲、随机对照临床试验以进一步验证其疗效。【Abstract】 Objective To compare the efficacy of traditional Chinese medicine (TCM) plus radiotherapy (RT) with RT alone on nasopharyngeal carcinoma (NPC) by Yiqi Yangyin Qingre Huoxue decoction (YYQHD) through a meta-analysis of all available randomized controlled trials. Methods Literature retrieval was conducted using the Cochrane Library, PubMed, EMBASE, CBMdisk, CNKI, VIP, and Wanfang Database electronically. Relevant journals and conference proceedings were also hand-searched until March 31, 2010. The quality of included studies was assessed according to the criteria recommended by the Cochrane handbook, and the Meta-analysis was performed for homogeneous studies using RevMan 5.0.23.0 Software. Results Basing on our search criteria, we found nine trials (795 patients) which all published in Chinese. Our results showed that TCM (YYQHD) plus RT compared with RT alone, improved immediate tumor response, survival, completion rate of RT, quality of life, and alleviation of adverse effect of patients with NPC. Conclusions Considering the limitations related to this Meta-analysis, it nevertheless presents credible evidence that TCM (YYQHD) plus RT is worthy of additional study. Therefore, further large-scale, muti-center, randomized, and double-blind trials are warranted.

    Release date:2016-09-08 09:24 Export PDF Favorites Scan
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