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find Author "解立新" 4 results
  • 氦氧混合气Heliox 在慢性阻塞性肺疾病治疗中的应用进展

    Heliox 是氦气和氧气相混合后制成的一种低密度混合气体, 通常应用于深水潜水作业防止肺减压伤的发生。由于Heliox 的特殊物理特性, 吸入Heliox 后可降低气体在支气管树中的流速阻力, 从而降低气道阻力, 因此为临床工作者所重视, 也被逐步应用到了临床声带障碍、喉炎、上气道阻塞、支气管炎及支气管肺发育异常等疾病, 以及重症监护室针对重症哮喘、慢性阻塞性肺疾病/ 慢性阻塞性肺疾病急性加重( COPD/AECOPD) 患者的治疗中。本文主要就Heliox 的物理学特性及作用原理, 以及在COPD/AECOPD 患者中的临床应用作一综述。

    Release date:2016-08-30 11:53 Export PDF Favorites Scan
  • Effects of Vaporized Perfluorocarbon Inhalation on Histopathology of Lung and Extra-Pulmonary Organs in Rabbits with Acute Lung Injury

    Objective To investigate the effects of vaporized perfluorocarbon( PFC) inhalation on histopathology of lung, small intestine, liver and kidney of acute lung-injured rabbits. Methods Eighteen New Zealand rabbits were randomly divided into 3 groups, ie. a conventional mechanical ventilation( CMV)group, a PFC group, and a control group. The rabbits were mechanical ventilated and intratracheally infused artificial seawater to induce acute lung injury. After ALI was established( PaO2 /FiO2 lt; 200 mm Hg) , the CMV group received CMV for 6 hours. The PFC group received PFC inhalation for 2 hours, and followed by CMV for 4 hours. And the control group was weaned from ventilation. Then they were sacrificed for histopathological measurement of lung, small intestine, liver and kidney. Results The rabbits in the control group died in 15 minutes after discontinuation of ventilation. Vaporized PFC inhalation can obviously improve oxygenation and attenuate the damage of the lung in contrast to CMV. Mild improvement was observed in small intestine, liver and kidney after vaporized PFC inhalation, but without statistical significance. Conclusion Vaporized PFC inhalation can improve oxygenation and attenuate lung injury in histopathology,but have no apparent protective effects on extra-pulmonary organs.

    Release date:2016-09-14 11:23 Export PDF Favorites Scan
  • Modeling the noninvasive bi-level positive airway pressure ventilation therapy system and simulated application

    Without artificial airway though oral, nasal or airway incision, the bi-level positive airway pressure (Bi-PAP) has been widely employed for respiratory patients. In an effort to investigate the therapeutic effects and measures for the respiratory patients under the noninvasive Bi-PAP ventilation, a therapy system model was designed for virtual ventilation experiments. In this system model, it includes a sub-model of noninvasive Bi-PAP respirator, a sub-model of respiratory patient, and a sub-model of the breath circuit and mask. And based on the Matlab Simulink, a simulation platform for the noninvasive Bi-PAP therapy system was developed to conduct the virtual experiments in simulated respiratory patient with no spontaneous breathing (NSB), chronic obstructive pulmonary disease (COPD) and acute respiratory distress syndrome (ARDS). The simulated outputs such as the respiratory flows, pressures, volumes, etc, were collected and compared to the outputs which were obtained in the physical experiments with the active servo lung. By statistically analyzed with SPSS, the results demonstrated that there was no significant difference (P > 0.1) and was in high similarity (R > 0.7) between the data collected in simulations and physical experiments. The therapy system model of noninvasive Bi-PAP is probably applied for simulating the practical clinical experiment, and maybe conveniently applied to study the technology of noninvasive Bi-PAP for clinicians.

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  • Construction of SARS Information System in Xiao Tang Shan Hospital

    Objective To summarize primary clinical data from Xiao Tang Shan Hospital (XTSH) Information System, to provide evidence for clinical data of emerging diseases. Method The primary data were extracted from XTSH information system, which related to demographic and background information, case history, prescriptions, laboratory tests, physical examination, vital sign, surgery, diagnostics and expenditures. The software for data verification was developed by Delphi language program. The information of SARS management was developed by Oracle Developer. Results XTSH information system for SARS management collected 1.09 million pieces of information covering 680 SARS cases. The database was functionally divided into inquiry window, conditional case list window and case details spread window, which provided information of SARS management and shaped a platform for further investigation. Quality control of clinical data was done by the software of SARS Information Real Control.Conclusions XTSH information system collected complete data of SARS management, which made healthcare, research and policy-making on SARS accessible, and made it possible to share resources and train the professionals.

    Release date:2016-09-07 02:27 Export PDF Favorites Scan
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