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find Author "谢娜" 3 results
  • Clinical Features of Infectious Mononucleosis with Liver Damage in Children

    目的 总结儿童传染性单核细胞增多症(IM)合并肝损害的临床特点及相关因素。 方法 对2000年1月-2012年1月入院收治48例合并肝损害IM与120例无肝损害IM的患儿年龄、性别、主要症状和体征、系统损害、实验室检查等资料进行回顾性分析。 结果 合并肝损害IM患儿血小板减少、异形淋巴细胞增加、丙氨酸氨基转换酶和天门冬氨酸氨基转移酶等血清酶学异常、持续发热、中重度肝脾肿大,以及多系统损害发生率较高;而咽峡炎、皮疹和浅表淋巴结肿大发生率较低;IM合并肝损害与发病年龄、性别无明显相关(r=0.127,0.075,P<0.05)。 结论 IM合并肝损害表现为持续发热、肝脾肿大、肝酶异常、血小板减少、异形淋巴细胞增加较常见。及时作肝功能等辅助检查,及早发现和干预IM肝损害,有助于减少重症IM的发生。

    Release date:2016-09-08 09:17 Export PDF Favorites Scan
  • Clinical Observation of Docetaxel Combined with Oxaliplatin Regimen for Advanced Gastric Cancer

    ObjectiveTo evaluate the efficacy and safety of docetaxel (DOC) combined with oxaliplatin (OXA) regimen in the treatment of advanced gastric cancer. MethodsSixty patients with advanced gastric cancer treated in our hospital from January 2008 to January 2011 were randomly divided into two groups. The treatment group (n=30) was given DOC combined with OXA regimen. Patients in this group were treated with DOC 75 mg/m2, ivgtt, d1; OXA 130 mg/m2, ivgtt, d4; with 21 days as a cycle. The control group (n=30) was given DCF regimen. Patients in the control group were treated with DOC 75 mg/m2, ivgtt, d1; cisplatin 75 mg/m2, ivgtt, d1; calcium folinate 200/m2, ivgtt, 2 h, d1-2; fluorouracil 400 mg/m2, bolus 10 minutes, fluorouracil 600 mg/m2 civ 22 h d1-2; also with 21 days as a cycle. All patients received two cycles of chemotherapy at least. The effective rate (complete remission+partial remission), adverse reactions, median survival time and quality of life were analyzed and compared between the two groups. ResultsThe effective rates in the treatment group and the control group were 60.0% and 46.7% respectively, showing a non-significant difference (P>0.05). The appetite increasing rate (70.0% vs 43.3%), the weight gain rate (60.0% vs 33.3%), and the Karnofsky score improvement rate (63.3% vs 30.0%) of the treatment group were significantly higher than those of the control group (P<0.05). The adverse reactions were fewer in the treatment group, and most of them were between grade Ⅰ and Ⅱ. The median time of disease progression (5.8 months vs 5.6 months) and the median survival period (11.8 months vs 9.2 months) of the treatment group were longer than those in the control group. ConclusionDOC combined with OXA regimen is effective in treating advanced gastric cancer. It can significantly improve the quality of life of the patients, and it has fewer adverse reactions. Meanwhile, the median survival period is prolonged. DOC combined with OXA regimen is worth to be applied in clinic.

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  • 危急值报告制度在肿瘤内科住院患者诊断和治疗中的应用体会

    目的 探讨持续改进危急值报告制度对肿瘤内科住院患者诊断和治疗的作用。 方法 收集2013年1月1日-2015年1月1日肿瘤内科危急值登记本上所有数据并进行整理分析。 结果 2013年1月1日-2014年1月1日(改进前)接到相关科室报告并记录有危急值的患者共96例,2014年1月2日-2015年1月1日(改进后)接到相关科室报告并记录有危急值的患者共61例。常见的异常指标为白细胞、血小板、血清钾、血清钠、血清钙、肌酐和尿酸。与改进前比较,改进后危急值重复报告率明显降低,患者的满意度明显提高,且未发生因危急值所致的医疗纠纷,差异有统计学意义(P<0.05)。 结论 根据科室实际情况持续改进危急值报告制度能更好地指导临床工作,保障患者医疗安全。

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