循环纤维细胞是一类外周血中骨髓来源的间充质祖细胞, 其细胞表面表达造血细胞、单核细胞和成纤维细胞系的三种细胞标记, 参与组织应对损伤和破坏后的反应。根据近年来大量动物实验的研究, 循环纤维细胞的分化、迁移以及功能提示其在以慢性炎症和大量胶原沉积为特征的疾病中起着重要作用。尽管这些细胞参与疾病发生发展的具体机制仍然不清楚, 但是近年来积累的临床资料表明循环纤维细胞计数可以作为慢性肺部疾病( 包括肺纤维化、哮喘) 进展的生物学标志。通过免疫调节来影响循环纤维细胞的分化、迁移以及功能, 进而改善慢性炎症并减少胶原沉积, 可能成为治疗慢性肺部疾病特别是肺纤维化研究的新方向。
Endoscopic technology can reduce the surgical incision, and on the basis of ensuring tumor safety, effectively improve aesthetic outcomes and enhance patient satisfaction. Endoscopic breast-conserving surgery can offer benefits to scar appearance for patients with early breast cancer; however, for patients with tumors in the lower quadrant, the trauma of surgery should be carefully considered. Endoscopic breast reconstruction provides a preferred option for the patients underwent total mastectomy by reshaping a scarless breast. The choice of surgery should be considered by oncological safety, postoperative aesthetic effects, patient’s willingness, and medical conditions. The more high-quality clinical studies are needed to provide reference for decision-making. The development of endoscopic technology will provide better treatment options for patients with breast cancer.