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find Author "费哲为" 4 results
  • Research Progress of Sentinel Lymph Node Biopsy in the Surgery of Thyroid Carcinoma

    ObjectiveTo summarize the research progress of sentinel lymph node biopsy (SLNB) in the surgery of thyroid carcinoma in recent years. MethodsLiteratures about the recent studies on categories of SLNB and the neck lymph node dissection conducted by SLNB in the surgery of thyroid carcinoma were reviewed following the results searched from PubMed and CNKI data base. ResultsSLNB has a high detection rate and it is of great significance to detect the occult metastatic lymph nodes and guide the neck lymph node dissection during operation. ConclusionThe SLNB, with its high accuracy rate on the detection of occult metastatic lymph nodes, guides neck lymph node dissection during operation in order that it can maximize the benefits of patients.

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  • Clinical Application Research of Fluorescent Tracer Technique in cN0 Papillary Thyroid Carcinoma

    ObjectiveTo explore the value of fluorescence tracer technique in sentinel lymph node (SLN) orientation of cN0 papillary thyroid cancer. MethodsThe total clinical data of 40 cT1-3N0M0 thyroid cancer patients admitted from January 2015 to January 2016 in our hospital were collected, and the SLN with indocyanine green (ICG) as fluorescent trace agent were observed and detected, and the effect of ICG detecting SLN and the guide role of SLNB on the dissection of the central area of neck lymph nodes by intraoperative frozen biopsy pathology and postoperative paraffin pathology were analyzed. ResultsA total of 40 thyroid cancer patients were treated by SLNB and then conducted by the dissection of the central area of neck lymph nodes, and 37 cases detected SLN, so the detection rate was 92.5% (37/40). And a total of 98 SLNs were detected, 1-5 for each case, average of 2.65/case. Intraoperative frozen pathological detected 28 cases of patients with metastases in SLN, and 9 patients without metastasis, including 1 case with postoperative pathology detecting micrometastasis in SLN and other 8 cases without metastasis in the central area of neck lymph nodes. Three cases who were not detected the SLN showed no metastases in final postoperative paraffin pathology. The SLNB of ICG fluorescent tracer was with a sensitivity of 96.6% (28/29), false-negative rate of 3.45% (1/29). ConclusionThe fluorescent tracer technique can guide the dissection of the central of neck lymph node of cN0 thyroid cancer patients accurately with a high detection rate and advantages of high sensitivity in detecting the SLN of thyroid cancer.

    Release date:2016-10-25 06:10 Export PDF Favorites Scan
  • Expression of microRNA-21 in Gastric Cancer of Different Tumor Stages

    ObjectiveTo quantitate expression of microRNA-21 (miRNA-21) in gastric cancer of different tumor stages and discuss its clinical value. Method The relative expressions of miRNA-21 were quantitated in the cancer tissues, corresponding normal gastric tissues adjacent to gastric cancer, and serums of 50 gastric cancer patients received opera-tion and confirmed gastric cancer by pathology and the serums of nongastric cancer patients in Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine and its Chongming Branch from January 2015 to January 2016 by real time quantitative PCR. ResultsThe relative expression level of miRNA-21 in the gastric cancer tissues was significantly higher than that in the normal gastric tissues adjacent to gastric cancer. Among the TNM stageⅠ, Ⅱ, Ⅲ of gastric cancer patients, the relative expression levels of miRNA-21 in the cancer tissues were 2.17 (1.48-2.90), 4.08 (2.30-4.86), 8.64 (5.82-18.20), respectively and the differences among these three stages were statistically significant (P<0.05). The relative expression level of the serum miRNA-21 in the gastric cancer patients was significantly higher than that in the nongastric cancer patients, which in the serums for stageⅠ, Ⅱ, and Ⅲpatients were 31.00 (24.60-37.15), 39.10 (28.90-39.80), 44.15 (38.95-56.68), respectively and the differences among three stages were statistically significant (P<0.05). The relative expression level of miRNA-21 in the serums and cancer tissues had a positive correlation (r=0.86, P<0.05). ConclusionMiRNA-21 appears to have a potential association with TNM stage of gastric cancer, which cautiously suggests that it might be a potential indicator for prediction of preoperative TNM stage of gastric cancer.

    Release date:2016-11-22 10:23 Export PDF Favorites Scan
  • 结直肠癌术后并发症的风险预测模型

    目的探讨与结直肠癌术后并发症相关的主要危险因素并建立风险预测模型。方法回顾性收集 2015 年 1 月至 2016 年 12 月期间于新华医院崇明分院、堡镇医院及庙镇医院行结直肠癌手术且符合本研究纳入条件患者的临床病理资料,分析结直肠癌术后并发症发生的危险因素并建立风险预测模型,同时采用回代样本进行验证。结果本研究共纳入符合条件的结直肠癌手术患者 450 例,术后发生并发症 67 例,并发症发生率为 14.9%。单因素分析结果显示,患者的年龄高、合并糖尿病、合并心脑血管疾病、合并慢性阻塞性肺炎、无术前化疗、ASA 分级高、手术持续时间长、TNM 分期晚、肿瘤分化程度低、主刀手术例数少、术中输血及术前营养不良这 12 个因素与结直肠癌根治术后并发症发生有关(P<0.05);进一步行多因素 logistic 回归分析结果显示,这 12 个因素是结直肠癌根治术后并发症发生的危险因素(P<0.05),通过将包括这 12 个危险因素与常数项建立的 logistic 回归风险模型判断结直肠癌术后并发症的灵敏度和特异度分别为 68.7%(46/67)和84.9%(325/383);采用 40 例回代样本进行验证,此模型判断结直肠癌术后并发症的灵敏度和特异度分别为 66.7%(18/27)和 84.6%(11/13)。结论本研究根据多因素 logistic 回归分析得出了 12 项结直肠癌术后并发症发生独立的危险因素并以此建立的回归风险模型能够较为准确地预测结直肠癌术后的并发症发生率。

    Release date:2021-02-08 07:10 Export PDF Favorites Scan
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