ObjectiveTo observe the ocular manifestations of presumed ocular tuberculosis in patients with pulmonary tuberculosis. MethodsOne hundred and fifty nine patients with pulmonary tuberculosis received examinations of visual acuity, slit lamp microscopy and indirect ophthalmoscopy. Those patients with retinochoroidal inflammatory lesions, retinal hemorrhages or detachments underwent fundus fluorescein angiography (FFA) and optical coherence tomography (OCT) to determine whether the presumed ocular tuberculosis was involved. There were 9 patients (16 eyes, 5.67%) of presumed ocular tuberculosis, including 5 males and 4 females. The age was ranged from 19 to 64 years old, with an average of 35.12 years. Seven patients were affected bilaterally and 2 patients affected unilaterally. There were 8 patients (15 eyes, 93.75%) with uveitis and 1 patient (1 eye, 6.25%) with central retinal vein occlusion (CRVO). The blood laboratory tests were negative in all cases. ResultsThe corrected vision was from light sensation to 0.15 in 6 uveitis eyes, 0.8 to 1.0 in 10 eyes. The anterior segment change was found in 10 eyes, which including granulomatous uveitis (8 eyes) and non-granulomatous uveitis (2 eyes). Granulomatous uveitis eyes had iris nodules, posterior synechia of the iris and mutton-fat keratic precipitates (KP). Non-granulomatous uveitis eyes had KP only. Choroidal tubercles were found in 7 eyes in which 3-7 off-white lesions of varying sizes were found with local retinal detachment. FFA revealed hypo-fluorescence with obscure boundary in arterial phase and arterial and venous phase, and hyper-fluorescence with obscure boundary in later phase. OCT showed retinal pigment epithelium uplift. There was 1 eye with CRVO, which had punctate, splinter and linear hemorrhage, white lesions in some hemorrhagic focus. ConclusionThe presumed ocular tuberculosis eyes showed mainly granulomatous inflammation and multiple choroid tubercles, and CRVO sometime.
ObjectiveTo observe the image characteristics of optical coherence tomography (OCT) in patients with primary vitreoretinal lymphoma (PVRL).MethodsA retrospective clinical study. Thirty-two eyes of 19 patients diagnosed with PVRL by vitreous pathology in the Department of Ophthalmology, Beijing Tongren Hospital from September 2016 to October 2019 were included in this study. There were 7 males and 12 females. The median age was 56 years. The mean time from symptom onset to final diagnosis was 6.1±3.8 months. The first diagnosis was uveitis in 12 cases (63.1%, 12/19), retinal vein occlusion in 2 cases (10.5%, 2/19), central retinal artery occlusion in 1 case (5.3%, 1/19), and suspected PVRL of camouflage syndrome in 4 cases (21.1%, 4/19). Routine ophthalmic examination and frequency-domain OCT examination were performed in all the patients, and typical images were stored for analysis. According to the examination results, PVRL OCT signs were divided into vitreous cells, inner retinal infiltration, outer retinal infiltration, retinal pigment epithelial (RPE) infiltration, sub-RPE infiltration, and subretinal fluid.ResultsVitreous cells were found in all eyes (100.0%, 32/32). RPE infiltrated were observed in 19 eyes (59.4%, 19/32), RPE infiltration in 16 eyes (50.0%, 16/32), outer retinal infiltration in 8 eyes (25.0%, 8/32), inner retinal infiltration in 16 eyes (50.0%, 16/32), and subretinal fluid in 4 eyes (12.5%, 4/32).ConclusionsPVRL OCT signs can involve vitreous and retinal anatomical levels, including vitreous cells, inner retinal infiltration, outer retinal infiltration, RPE infiltration, sub-RPE infiltration and subretinal fluid. The same patient can show multiple signs at the same time.