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find Keyword "迷走神经" 36 results
  • The Effect of Highly Selective Vagotomy Plus Mucosal Antrectomy and Highly Selective Vagotomy Alone on Motor Function of Gastric Antrum

    Objective To investigate the effects of highly selective vagotomy plus mucosal antrectomy (HSVMA) and highly selective vagotomy (HSV) alone on the functions of the gastric antrum. MethodsEighteen dogs and 48 patients with chronic duodenal ulcer were tested. The time of gastric emptying, antral myoelectric activity, antral pressure were measured 4-6 months after operation in 18 dogs which were randomized into the control, HSV and HSVMA groups. The gastric evacuation, frequency and amplitude of electrogastrography (EGG) were observed 4-6 months after operation in 48 patients who were randomly divided into HSV (20 patients) and HSVMA (28 patients) group, their preoperative values were considered as control group. ResultsIt was found by barium meal examinations that the shape of the stomach and duodenum was normal and gastric peristalsis was clearly visible in all the animals and patients of two postoperative groups. The beginning and ending time of gastric emptying were (5.0±0.06) min and (4.0±0.4) h respectively in the dogs of HSVMA group, which were similar to those of the dogs of control and HSV group (Pgt;0.05). The frequency of the antral myoelectric action potential was (3.11±0.65 ) cycles/min in the dogs of HSVMA group, the frequency of EGG was (3.25±0.75) cycles/min in the patients of HSVMA group, which were significantly lower than that of the dogs or patients of control and HSV group (P<0.05). Injection of pentagastrin in dogs or taking meal in patients significantly increased the antral pressure or amplitude of EGG. Conclusion The motor function of the reconstructed antrum in the HSVMA group approaches the normal level despite a lower antral myoelectric frequency. It is believed that HSVMA will be a choice for the treatment of duodenal ulcer.

    Release date:2016-08-28 05:10 Export PDF Favorites Scan
  • Effect of Injection with Bradykinin in Atrium Dextrum on Respiration in Neonatal Rats

    目的 探讨在Sprague-Dawley大鼠右心房注射缓激肽对呼吸的影响。 方法 7~9 d和21~23 d大鼠在迷走神经完整和迷走神经切断的情况下从右心房注射缓激肽,观察呼吸指标的变化。 结果 ① 右心房注射缓激肽后,7~9 d大鼠出现呼吸暂停,而在21~23 d大鼠仅出现呼吸抑制(P<0.05);② 切断迷走神经后,右心房注射缓激肽在两组大鼠均不再出现呼吸暂停。 结论 右心房注射缓激肽在7~9 d大鼠产生呼吸暂停,且依赖于迷走神经的完整性。

    Release date:2016-09-08 09:13 Export PDF Favorites Scan
  • THE EFFECT OF HIGHLY SELECTIVE VAGOTOMY AND MUCOSAL ANTRECTOMY ON SERUM GASTRIN AND GASTRIC EMPTYING

    Forty-two patients with duodenal ulcer underwent highly selective vagotomy and mucosal antrectomy (HSV+MA) and were followed up for 3 years. Two weeks, 1 year and 3 year after operation, serum gastrim level and gastric emptying capacity were tested. The results show that he postoperative levels of serum gastrin were lower than the preoperative ones, but wih no significant difference (P>0.05). Only a few patients had delayed gastric emptying 2 weeks and 1year after operation,but it returned to normal in 3 years .The authors conclude that HSV+MA is a better operative treatment for duodenal ulcer since it can abolish the factors of postoperative ulcer recurence and perserve the functions of the antrum and the pylorus.

    Release date:2016-08-29 03:44 Export PDF Favorites Scan
  • GROSS AND HISTOLOGICAL OBSERVATIONS OF DOG’S STOMACH AFTER HIGHLY SELECTIVE VAGOTOMY AND MUCOSAL ANTRECTOMY

    Six dogs underwent high selective vagotomy and mucosal antrectomy (HSV+MA). The gross and histological change of dog’s stomach were observed at 4-6 months after operation. It was found that the reconstructed antrum healed well and there was no stasis and distension in the stomach .The appearance of the nerves in muscular layer of the antrum was normal. No serious gastritis and mucosal atrophy was observed. These results indicat that HSV+MA is a reasonable procedure for the treatment of duodenal ulcer.

    Release date:2016-08-29 03:44 Export PDF Favorites Scan
  • 迷走神经刺激术治疗药物难治性癫痫中影响治疗效果的相关因素分析

    迷走神经刺激术(Vagus nerve stimulation,VNS)自 1997 年经美国食品药品监督局批准以来,应用越来越广泛,目前为止,全世界约有 80 000 多例药物难治性癫痫患者接受了 VNS 治疗。大量文献证实,VNS 不仅能减少药物难治性癫痫患者的发作频率,还能减轻癫痫发作严重程度、缩短发作的持续时间或发作后的恢复时间,改善患者生活质量。尽管如此,仍有一部分药物难治性癫痫患者 VNS 治疗效果不理想,甚至无效。为此,选择适合 VNS 治疗的患者,术前根据相关影响因素预测治疗效果尤为重要。文章以综述形式阐述可能影响 VNS 治疗癫痫效果的因素。

    Release date:2018-05-22 02:14 Export PDF Favorites Scan
  • 迷走神经刺激治疗难治性癫痫:欧洲347例儿童24个月随访研究

    为了进一步探究迷走神经刺激术(Vagus nerve stimulation, VNS)在儿童难治性癫痫中的作用, 进行了连续随访达24个月, 系迄今最大样本量的多中心回顾性研究。主要目标是评估VNS术后癫痫主要发作类型(定义为最易致残的发作类型)的频率变化, 连续收集从基线开始一直到植入术后6、12及24个月的患者数据。统计人群包括347例患者(年龄6个月~17.9岁)。在植入后第6、12及24月, 分别有32.5%、37.6%及43.8%的患者主要发作类型的发作与基线相比, 有50%减少。亚组分析中, 在试验期间没有更换抗癫痫药物(AEDs)的患者有更好的反应。较好的结果也存在于所有次要指标, 包括癫痫发作持续时间、严重程度和发作后严重程度、生活质量、安全性等。多组分析表明VNS每天总放电量与反应效率有相关性。VNS治疗被认为是局灶性结构性癫痫患儿的附加治疗, 指那些经过两种及以上AEDs治疗后仍不适合外科手术的患者。全面性发作, 有遗传及结构异常的, 如Dravet综合征和Lennox-Gastaut综合征的患者能从VNS治疗中获益。结果表明随访24个月后, 难治性癫痫患儿通过附加的VNS治疗能够减少癫痫发作频率, 安全性良好; 多组分析表明VNS有剂量相关性。

    Release date:2016-10-02 06:51 Export PDF Favorites Scan
  • The Effect of Right Atrial Injection of PGE-2 on Respiration in Neonatal Rats

    目的:探讨在不同年龄SD大鼠右心房注射前列腺素E2(PGE2)对呼吸的影响。方法:7~9 d和21~23 d大鼠在迷走神经完整和迷走神经切断的情况下从右心房注射PGE-2,观察呼吸指标的变化。结果:①右心房注射PGE2在7~9 d和21~23 d大鼠中均引起呼吸暂停,呼气延长时间分别为基础呼气时间的9.5和7.5倍(Plt;0.05);②切断迷走神经后,右心房注射PGE-2在7~9 d和21~23 d大鼠均不再产生呼吸暂停,仅出现轻微呼吸抑制。结论:右心房注射PGE2在7~9 d和21~23 d大鼠均产生呼吸暂停,且依赖于迷走神经的完整性。

    Release date:2016-09-08 09:54 Export PDF Favorites Scan
  • Efficacy and predictive factors analysis of vagus nerve stimulation in patients with refractory MRI-negative epilepsy

    ObjectiveTo investigate the efficacy of vagus nerve stimulation (VNS) in patients with refractory magnetic resonance imaging (MRI)-negative epilepsy and to evaluate potential clinical predictors. MethodsA retrospective collection of efficacy data was conducted on 24 patients with intractable MRI-negative epilepsy treated with VNS, who were followed up for more than six months, at Beijing Tiantan Hospital and Beijing Fengtai Hospital from January 2016 to September 2023. Patients were divided into two subgroups based on their response to VNS: responders (≥50% reduction in seizure frequency) and non-responders (<50% reduction in seizure frequency). The relationship between preoperative clinical data and VNS efficacy was further analyzed to identify potential predictors of VNS efficacy. ResultsA total of 24 patients were included, with an average age of (14.26±8.39) years old. Seizure frequency was reduced by more than 50% in 37.5% of patients, and 8.3% of patients achieved seizure-free after VNS treatment. Preoperative seizure frequency and interictal epileptiform discharge type were significantly associated with VNS efficacy (P<0.05). Multivariate regression analysis showed that a monthly seizure frequency of less than 100 and focal interictal epileptiform discharges were independent predictors of VNS efficacy (P<0.05). ConclusionVNS is an effective treatment for patients with refractory MRI-negative epilepsy. Lower monthly seizure frequency and focal interictal epileptiform discharges are potential predictors of VNS efficacy. These findings provide important references for clinicians in selecting and evaluating patients for VNS treatment.

    Release date:2024-08-23 04:11 Export PDF Favorites Scan
  • 超声引导下穿刺术并发血管迷走神经性晕厥的护理

    目的 探讨超声引导下穿刺术后并发血管迷走神经性晕厥患者的护理方法及要点。 方法 对2011年7月-2012年6月32例血管迷走神经性晕厥患者进行严密观察,并针对血管迷走神经性晕厥发生的相关因素采取积极的应对护理措施。 结果 所有患者经过及时正确的处理后生命体征恢复稳定。 结论 及时观察、早期发现及早期处理是超声引导下穿刺致血管迷走神经性晕厥并发症护理的正确原则。

    Release date:2016-09-07 02:37 Export PDF Favorites Scan
  • 贲门癌手术对胆囊收缩功能的影响

    目的 研究贲门癌患者围手术期对胆囊功能的影响,减少术后消化道并发症。方法 将82例贲门癌患者按手术中是否保留迷走神经,分为两组,Ⅰ组(n=65): 手术中未保留迷走神经;Ⅱ组(n=17): 手术中保留迷走神经。用B型超声波测量胆囊容积、胆囊收缩功能,并进行手术前后自身对照和两种术式的对比研究。结果 Ⅰ组胆囊容积、收缩功能术前与术后比较差别具有显著性意义(P<0.01),Ⅱ组改变不明显(P>0.05);术后胆囊容积两组比较差别具有显著性意义(P<0.01);Ⅰ组患者术后消化道症状明显,胆囊结石发生明显增多。结论 保留迷走神经干的贲门癌切除术有利于患者术后的胆囊功能恢复和提高生活质量。

    Release date:2016-08-30 06:34 Export PDF Favorites Scan
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