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find Author "邓馨" 9 results
  • 眶额区病变及脑脊膜膨出表现为颞叶内侧发作一例

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  • 在常规表面电极脑电图检测中慎用“表面蝶骨电极”

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  • 非惊厥性发作持续状态脑电图一例报告

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  • 皮质发育畸形核磁共振成像与脑电图异常部位不一致四例

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  • 限局性皮质发育障碍分型、诊断和治疗

    限局性皮质发育障碍(Focal cortical dysplasia, FCD), 特点为神经元迁移、增殖及分化异常, 导致的皮质分层异常及出现异常神经元、气球细胞。FCD发作机制与多种因素有关, 哺乳动物mTOR异常是FCD结构和电生理异常的基础, 病毒、基因、影响神经元后期迁移的脑损伤均可引起FCD。FCD易于产生癫痫样发放并扩布至临近部位甚至远隔部位。国际抗癫痫联盟(ILAE)基于组织学并结合临床以及神经影像学将FCD分为:FCDⅠ型(FCDⅠa型、FCDⅠb型、FCDⅠc型)、FCDⅡ型(FCDⅡa型、FCDⅡb型)、FCDⅢ型(FCDⅢa型、FCDⅢb型、FCDⅢc型、FCDⅢd型)。癫痫发作是FCD最常见的症状, 并且发作类型仅与病变部位有关。FCD患者40%~70%有限局性发作及发作间期脑电图异常。颅内电极可记录到持续癫痫样发放, 分为三型:①募集型; ②反复暴发型; ③持续性或节律性棘波>10 s。磁光振成像(MRI)为发现FCD最重要的手段, 但区分不同亚型有一定困难。MRI后处理技术如VBM、曲线重组形态分析程序等可以明显提高发现率。MRI主要异常为灰白质交界处模糊、皮质增厚、皮质信号异常、皮质下白质信号异常、穿透现象、沟底发育障碍及脑回脑沟异常。抗癫痫药治疗效果不佳, 外科治疗可使60%左右的患者发作消失

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  • 灰质异位与癫痫发作

    灰质异位在药物难治性癫痫中并非少见,是胚胎发育阶段神经元移行障碍导致的大脑畸形之一,其主要原因有遗传因素(最常见的是 FLNA 基因突变)、肌动蛋白缺乏及母亲在妊娠期接受 X 线或其他外界因素的影响。灰质异位癫痫发作的机制尚不完全了解,据颅内电极尤其是立体定向脑电图(SEEG)研究发现,发作多起源于异位灰质及相关皮质两者,少数起源于异位灰质或大脑皮质。灰质异位的诊断主要依据为在大脑内有与大脑皮质信号一致的结节、团块或与皮质平行的带状异常。对于合并癫痫发作者头皮脑电图意义不大,颅内电极尤其是 SEEG 可以发现发作的起源、异位灰质与大脑皮质的关系,以及异常网络间的联系,所以 SEEG 是必不可少的检测项目。灰质异位合并的癫痫,绝大多数为药物难治性患者,在 SEEG 指导下的外科治疗可以获得非常好的疗效。

    Release date:2018-11-21 02:23 Export PDF Favorites Scan
  • 双外侧裂综合征伴发作性肢体感觉障碍及手足畸形一例报道

    Release date:2021-01-07 02:57 Export PDF Favorites Scan
  • 高龄老年患者颅内巨大脑膜瘤术后出现部分性运动发作一例并文献复习

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  • EEG waveform and spectrum-power analysis under different settings of filter parameter

    Objective To explore the change of EEG waveform recorded by clinical EEG under different filtering parameters. Methods22 abnormal EEG samples of epilepsy patients with abundant abnormal waveforms recorded in Peking University first hospital were selected as the case group (abnormal group), and 30 normal EEG samples of healthy people with matched sex and age were selected as the control group (normal group). Visual examination and power spectrum analysis were then performed to compare the difference of wave forms and spectrum power under different settings of filter parameter between the two groups. ResultsThe results of visual examination show that, lower high-frequency filtering has an effect on the fast wave composition of EEG and may distort and reduce the spike wave. Higher low-frequency filtering has an effect on the overall background and slow wave activity of EEG and may change the amplitude morphology of some slow waves. The results of power spectrum analysis show that, Compare the difference between the EEG normal group and the abnormal group, the main difference under the settings of 0.5~70Hz was on the θ and α3 frequency band, different brain regions were slightly different. In the central region, the difference in the high frequency band (α3, γ1, γ2) decreases or disappears with the decrease of the high frequency filtering. In the rest of the brain, the difference in the δ band appears gradually with the increase of the low frequency filtering. Compare the difference between frontal area and occipital area under different filter set, for the normal group, under the settings of 0.5 ~ 70 Hz, the difference between two regions is mainly on the θ, γ1 and γ2 band. When high frequency filter reduces, the difference between two regions on high frequency band (γ1, γ2) are gradually reduced or disappeared. And when low frequency filter increases, the difference on δ band appears. For the abnormal group, the difference between frontal and occipital region under the settings of 0.5 ~ 70 Hz is mainly on γ1 and γ2 bands. When the high-frequency filter decreases, the difference between two regions on high-frequency bands are gradually decreased or disappeared. All the results can be corrected by FDR. ConclusionThe results show that the filter setting has a significant influence on EEG results. In clinical application, we should strictly set 0.5 ~ 70 Hz bandpass filtering as the standard.

    Release date:2022-04-28 09:14 Export PDF Favorites Scan
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