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find Author "邵军" 5 results
  • Expressions of IL-17 and IL-27 in Liver Tissue of Hepatic Alveolar Echinococcosis

    ObjectiveTo detect expressions of interleukin-17 (IL-17) and interleukin-27 (IL-27) proteins in liver tissue of hepatic alveolar echinococcosis. MethodsThe edge liver tissues (from the lesion edge 0.5 cm) and the normal liver tissues (from the lesion edge 5 cm) of 20 patients with hepatic alveolar echinococcosis in the Affiliated Hospital of Qinghai University were collected and stored at-80℃ freezer. The immunohistochemical method was used to detect the expressions of IL-17 and IL-27 proteins in these two tissues. ResultThe positive rates of IL-17 and IL-27 protein expressions in the edge liver tissues were significantly higher than those in the normal liver tissues[IL-17:80.0% (16/20) versus 10.0% (2/20), χ2=12.36, P < 0.01; IL-27:85.0% (17/20) versus 20.0% (4/20), χ2=12.36, P < 0.01]. ConclusionHigh expressions of IL-17 and IL-27 protein in edge liver tissue might participate in progress of hepatic alveolar echinococcosis.

    Release date:2016-10-02 04:54 Export PDF Favorites Scan
  • Antibody microarray analysis of the tissue apoptosis factors in patients with hepatic alveolar echinococcosis

    Objective To detect and analize the expressions and it’s clinical significance of apoptosis factors in hepatic alveolar echinococcosis tissues by using antibody chip technology. Methods The liver tissue specimens (including the edge of lesions and normal liver tissues) of surgical resection of 6 patients with hepatic alveolar echinococcosis in Affiliated Hospital of Qinghai University were collected. The tissue protein was extracted and the level of apoptosis was detected by antibody chip technology. The data were analyzed by AAH-APO-G1 software. Results The expression levels of 5 kinds of apoptosis factors (Bad, Fas, IGFBP-3, P21 and XIAP) in the liver tissues of the marginal zone of hepatic alveolar echinococcosis were compared with that of the normal liver tissues, and the difference was statistically significant (P<0.05). The expression levels of Bad, Fas, IGFBP-3 and P21 were up-regulated, and the expression level of XIAP was down regulated. Conclusions Apoptosis-related factors play a role in the progression of the hepatic alveolar echinococcosis, there may be contact with the immune escape mechanisms, while promote apoptosis factor and inhibitory apoptosis factor that may exist the function imbalance, so more in-depth exploration the mechanism of apoptosis factors on hepatic alveolar echinococcosis in diagnosis and treatment have important significance.

    Release date:2017-04-18 03:08 Export PDF Favorites Scan
  • Literature review of the diagnosis and treatment of bone hydatid disease in China from 1975 to 2015

    Objective To analyze the clinical manifestations, diagnosis, treatment and prognosis of bone hydatid disease in China by literature review. Methods We searched the databases of China National Knowledge Infrastructure and Wanfang for case reports of bone hydatid disease published from 2000 to 2015 in China. Data were extracted by using a standardized form and a retrospective clinical analysis was performed. Results A total of 21 relevant literatures published from 2000 to 2015 were included, including 87 cases of bone hydatid disease treated from 1975 to 2015. The regional distribution of bone hydatid disease was mainly concentrated in the animal husbandry areas in China. In terms of diagnosis basis, imaging examination was mentioned in 54 cases (62.1%), laboratory examination was mentioned in 32 cases (36.8%), and pathologic examination was mentioned in 8 cases (9.2%), etc. Surgical treatment was the main treatment, and some treatments were combined with chemotherapy. The outcomes of bone hydatid disease were relatively poor. In the 44 cases whose outcomes were reported, 26 cases (59.1%) had recurrence, 18 cases were cured (40.9%), 10 cases (22.7%) underwent re-operation, and 2 cases (4.5%) died. Conclusions Bone hydatid disease is rare. Surgical treatment is still the main method for treating bone hydatid disease. The rate of recurrence of bone hydatidosis is relatively high, so it is very important to explore new methods for diagnosis and treatment of bone hydatid disease.

    Release date:2018-09-25 02:22 Export PDF Favorites Scan
  • Retrospective Analysis of Echinococcosis Outside Liver in China

    ObjectiveTo summarize regional and body distributions, diagnosis, treatment, and prognosis of echinococcosis outside liver in China. MethodsThe published literatures about echinococcosis outside liver in China (not including Hong Kong, Macao and Taiwan regions) from 2000 to 2015 were searched in the databases of CNKI and Wanfang. Data were extracted by using a standardized form and a retrospective clinical analysis was performed. ResultsA total of 66 published literatures about echinococcosis outside liver and data of 884 cases reported were collected. The regional proportions of cases reported were different, five high regions were Xinjiang (68.73%), Tibet (8.77%), Ningxia (6.75%), Qinghai (6.41%), Gansu (5.62%). The organ distributions of cases reported were also different, five high organs were lung (61.09%), bone (9.95%), brain (9.73%), spleen (8.60%), and kidney (6.22%). The main clinical symptoms of patients with echinococcosis outside liver included general asymptoms and organ dysfunction, and the most common examinations were X-ray (30.77%), B ultrasound (7.47%),CT(17.43%), MR (1.59%), and laboratory (36.31%). The main therapy choice was operation (73.30%), and some patients were performed operation combined with drug therapy. ConclusionRegional distribution of echinococcosis outside liver is almost the same as total echinococcosis, and distributed more in organs rich in blood supply, its clinical diagnosis mainly depends on imaging and immunology examination, and operation is still the main therapy choice.

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  • 泡球蚴囊液对大鼠肝星状细胞TGF-β1、IL-6及TNF-α表达的影响

    目的观察泡球蚴囊液对大鼠肝星状细胞(HSC-T6)中转化生长因子β1(TGF-β1)、白细胞介素6(IL-6)及肿瘤坏死因子-α(TNF-α)表达的影响,以初步揭示泡型肝包虫病免疫调节作用的潜在机理。 方法以泡球蚴囊液中蛋白成分的浓度代表囊液浓度,分别以0、0.01、0.025、0.05、0.1、0.2、0.4、0.9、1.7、3.4、6.8及13.5 mg/mL的泡球蚴囊液干预大鼠HSC-T6细胞,作用24 h后收集各组细胞上清,采用酶联免疫吸附法检测上清中TGF-β1、IL-6及TNF-α的浓度。 结果以不同浓度泡球蚴囊液(0~13.5 mg/mL)干预后,HSC-T6细胞培养液上清中的TGF-β1浓度几乎不变,各浓度组间两两比较差异均无统计学意义(P>0.05)。当泡球蚴囊液浓度≤3.4 mg/mL时,上清中IL-6的浓度趋于平稳,各浓度组间两两比较差异均无统计学意义(P>0.05);当泡球蚴囊液浓度为6.8和13.5 mg/mL时,IL-6浓度较0 mg/mL组均升高,差异均有统计学意义(P<0.01)。当泡球蚴囊液浓度≤0.2 mg/mL时,上清中的TNF-α浓度趋于平稳,各浓度组间两两比较差异均无统计学意义(P>0.05);当泡球蚴囊液浓度为0.4 mg/mL时,TNF-α浓度达到最大,为0 mg/mL组的3.53倍(P<0.05);此后随浓度增高TNF-α浓度又逐渐降低,但仍高于0 mg/mL组(P<0.05)。 结论IL-6和TNF-α可能在肝星状细胞介导的泡型肝包虫病的纤维化和组织损伤中扮演重要角色,而TGF-β1的作用尚不确定。

    Release date:2016-12-21 03:35 Export PDF Favorites Scan
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