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find Keyword "重度烧伤" 4 results
  • EFFECT OF LOW-DOSE CYCLOPHOSPHAMIDE ON THE APOPTOSIS OF LUNG PARENCHYMA CELLS IN THE EARLY SEVERE BURN STAGE IN RATS

    Objective To study the effect of low-dose cyclophosphamide (CY) on apoptosis of lung parenchyma cells in the early severe burn stage in rats. Methods Ninety clean SD male rats were randomly divided into 3 groups: the normal group (n=10), the experimental group (n=40) and the burn group (n=40). The model of degree III with 30% burn area was made in the experimental group and the burn group. CY (2 mg/kg) was injected into the abdominal cavity right after burn in the experimental group. No treatment was done in the normal group and burn group. Lung tissues were obtained at 3, 6, 12and 24 hours, respectively, after burn, and were observed by HE staining. Apoptosis of lung parenchyma cells was observed by TUNEL. Results Lung tissues were observed under the opticalmicroscopy in the normal group: the pulmonary structure was clear, and there were no inflammatory cells and exudation in the alveolar space and bronchial lumen. Besides, a few RBCs were seen. Pathological changes of lung tissues were observed under the opticalmicroscopy in the burn group: alveolar septum was obviously widened; alveolar wall was destroyed; interstitial edema and atelectasis occurred; and pathological lesion was gradually aggravated as time passed by. The pathological lesion of lung tissues mentioned above in the experimental group was better than those in the burn group. Compared with the normal group, the apoptosis ratio of lung parenchyma cells continuously increased in the burn group from the 3 hour after burn, and reached the peak at 12 hours. There were significant differences between the two groups (P lt; 0.05). However, in the experimental group, the apoptosis ratio of lung parenchyma cells increased at 3 hours after burn, cut down to normal at 6 and 12 hours, respectively, and notably decreased at 24 hours. There were significant differences between the experimental group and the normal group (P lt; 0.05). Compared with the burn group, the apoptosisrate of lung parenchyma cells in the experimental group began to decrease strikingly from the 6 hours after burn, and there were significant differences between the two groups (P lt; 0.05). Conclusion Low-dose CY can restrain the apoptosis of lung parenchyma cells in the early severe burn stage in rats and alleviate the injury of the lung.

    Release date:2016-09-01 09:19 Export PDF Favorites Scan
  • 批量烧伤患者的急救护理

    目的 探讨批量重度烧伤患者急救护理方法。 方法 于2012年7月11日一次性收治严重大面积烧伤患者13例。其中特重大烧伤伴中、重度呼吸道损伤者8例。入院时立即启动应急预案,组织医护人员合理分工、配合,抢救有序,立即建立静脉通道,气管切开,呼吸机辅助呼吸,创面清创处理,加强疼痛、心理护理,积极做好分流工作。 结果 13例中除1例因烧伤后因多脏器功能衰竭死亡,其余12例均平稳渡过休克期,在短期内治愈出院,生活能自理,随访满意。 结论 健全的抢救预案、第一时间建立指挥领导小组、抢救时人力合理安排、急救药品及物品准备充足、丰富的临床经验、较强的综合应变能力,抢救人员配合默契,护理中严密全程监测病情、对重点伤员重点实施心理护理,可提高烧伤患者的抢救成功率,减少并发症发生。

    Release date:2016-09-07 02:34 Export PDF Favorites Scan
  • 重度烧伤并发下肢深静脉血栓开线的原因及护理对策

    目的探讨重度烧伤康复期深静脉血栓形成(DVT)的原因及护理对策,降低重度烧伤患者住院期间DVT的发生率,提高其治愈率。 方法对2012年1月-2013年2月发生重度烧伤且并发DVT的5例患者,予以制动、防止腹压增加及药物治疗,并采取积极有效的护理措施,促进下肢静脉回流,改变血液浓缩及高凝状态,保护血管内膜不受损伤,以预防深静脉血栓的发生。 结果64例患者仅5例发生DVT,经积极处置和护理全部治愈。 结论重度烧伤患者住院时间长,卧床时间久,极易发生下肢DVT,故重在预防,一旦发生,及时采取制动、溶栓等措施是保证患者康复的关键。

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  • 预见性护理在重度烧伤患者并发应激性溃疡中的应用及效果观察

    目的探讨预见性护理在重度烧伤患者并发应激性溃疡中的应用及效果观察。 方法将2012年 1月-12月收治的96例患者随机分为对照组与干预组,对照组采取常规护理措施,干预组实施预见性护理措施,观察两组患者并发应激性溃疡的发生率。 结果对照组发生应激性溃疡16例,发生率为33.3%,干预组发生应激性溃疡7例,发生率为14.6%,两组发生率差异有统计学意义(χ2=4.631,P=0.031)。 结论对重度烧伤患者实施综合预见性护理,结合必要的药物治疗,可有效降低应激性溃疡的发生,提高患者及家属的满意度。

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