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find Author "陈硕" 8 results
  • 氨甲环酸用于脊柱手术中的研究进展

    骨科大手术常常伴随大量失血及术中术后的输血治疗。而输血存在诸多风险,如发热、感染、输血反应、输血相关传染病等。最近的十多年时间里,氨甲环酸作为一种围手术期止血及减少输血的药物得到广泛应用。综合国外有关氨甲环酸在脊柱手术中应用的文献可以发现,氨甲环酸可有效降低围手术期的失血和输血,降低住院费用,减少住院时间,同时并未增加血栓等并发症的发生率。但在脊柱手术中氨甲环酸使用的最佳剂量、给药方式及使用时间尚无定论,需进一步研究。

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  • Clinical Analysis of Subsequent Non-operative Vertebral Compressible Fracture after Percutaneous Vertebroplasty

    ObjectiveTo explore the therapeutic effects and clinical characteristics of repeated percutaneous vertebroplasty (PVP) on subsequent non-operative osteoporotic vertebral compressible fractures (OVCF) after initial PVP for OVCF. MethodsFrom January 2008 to May 2013, 277 patients (331 vertebral bodies) with OVCF who were regularly followed up had underwent PVP. Among the 277 patients, the second treatment group included 42 patients who developed subsequent OVCF, which were retreated by PVP. And they were divided into adjacent new OVCF group (group A, 19 patients) and non-adjacent new OVCF group (group B, 23 patients). Analgesic effects and functional improvements were compared between the initial and second treatment. The interval of new OVCF after initial surgery, complications, and other clinical characteristics including age, gender, history of trauma, the amount of injected polymethylmethacrylate (PMMA) and PMMA leakage were compared between group A and B. ResultsThe improvement rates of visual analogue scale scores were (64.6±12.6)% in the initial treatment group and (67.4±12.8)% in the second treatment group (P>0.05). The improvement rates of Oswestry Disability Index (ODI) were (60.6±13.3)% in the initial treatment group and (62.6±12.9)% in the second treatment group (P>0.05). The interval of incidence of subsequent new OVCF after the initial treatment were (62.4±45.5) days in group A and (203.7±77.6) days in group B, respectively (P<0.05). There were no significant differences in age, gender, history of trauma, the amount of injected PMMA and PMMA leakage between group A and group B (P>0.05). No surgery-related complications occurred after the second treatment except asymptomatic cement leakage in 5 patients, one of whom suffered from adjacent OVCF 3 months after the operation. ConclusionThe therapeutic effect of repeated PVP for new OVCF on alleviating the pain and improving the function is just as the effect of the initial operation. Adjacent new OVCF primarily occurs earlier after initial PVP.

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  • OPERATIVE TREATMENT OF TERRIBLE TRIAD OF THE ELBOW

    Objective To retrospectively reviewed the operative therapy of the terrible triad of the elbow. Methods From October 2003 to September 2007, 10 cases of terrible triad were treated, with an elbow dislocation and an associated fracture of both the radial head and the coronoid process. There were 3 males and 7 females with the age of 18-66 years. The injury was caused by traffic accidents in 4 cases, fall ing from a height in 4 cases, and tumbl ing in 2 cases. The coronoid process fractures of the patients were 5 cases of type I, 3 cases of type II and 2 cases of type III according to Regan- Morrey classification. The radial head fractures of the patients were 1 case of type I, 6 cases of type II and 1 case of type IIIaccording to Mason classification, and their radial heads of the other 2 patiants were resected before they were in hospital. The general approach was to repair the damaged structures sequentially from deep to superficial, from coronoid to anterior capsule to radial head to lateral l igament complex to common extensor origin. And selected cases were repaired of the medial collateral l igaments and assisted mobile hinged external fixation to keep the forearm fixed in functional rotation position. The function of the elbows were evaluated with the criteria of the HSS2 score system. Results The other wounds healed by first intention except 1 case which had infection 7 days after operation and whose soft tissue defect in posterior elbow were repaired with the pedicle thoracoumbil ical flap. The patients were followed up 6 to 51 mouths (mean 24.9 mouths). The fracture heal ing time was 6 to 20 weeks (mean 9.6 weeks). Six mouths postoperatively, the mean flexion-extension arc of the elbow was 106.5° (85-130°), and the mean pronation-supination arc of the forearm was 138°( 100-160°) respectively. According to the criteria of the HSS2 score, the results were excellent in 4 cases, good in 4 cases, and fair in 2 cases. No compl ications such as stiffness and ulnohumeral arthrosis occurred. The radial nerve injury was found in 1 patient 1 day after operation who was treated with neurolysis, and the nerve function was recovered after 4-6 months. And heterotopic ossification occurred in 6 patients 6 months after operation and radiographic subluxation developed in 1 patient 36 months after operation, and conservative treatment weregiven. Conclusion The terrible triad of the elbow can lead to serious elbow instabil ity and should be treated with operationto restore the anatomic structures, to repair the articular capsule and the collateral l igament, using the adjuvant hinged external fixation and early exercise to avoid immobil ization and recover the articular function.

    Release date:2016-09-01 09:05 Export PDF Favorites Scan
  • Evaluation of CT-guided Percutaneous Iliosacral Screw Fixation in Treating Unstable Pelvic Fracture

    目的 探讨CT导航下经皮骶髂螺钉固定技术治疗骨盆环损伤的安全性及临床疗效。 方法 对2009年1月-2011年3月期间我科收治的16例骨盆后环骨折脱位患者资料进行回顾性分析,所有患者均在计算机导航系统辅助下采用经皮骶髂螺钉固定技术进行治疗。 结果 16例患者骶1平面共植入18枚骶髂螺钉,其中14例单侧植入1枚螺钉。14例患者获得随访,随访时间14~49个月,平均19个月。根据Majeed临床效果评定标准:满意8例,良好5例,差1例。所有随访患者均无神经、血管损伤、骶髂螺钉松动、断裂等并发症。 结论 经皮骶髂螺钉固定技术是恢复骨盆后环稳定性的一种安全、有效的方法,具有创伤小、临床效果好、并发症少、手术操作简便、性价比高等优势,值得临床推广。

    Release date:2016-09-08 09:12 Export PDF Favorites Scan
  • BIOMECHANICAL STUDY ON POSTEROLATERAL ROTATORY INSTABILITY OF ELBOW IN CORONOID PROCESS FRACTURE WITH ANTERIOR BUNDLE INJURY OF MEDIAL COLLATERAL LIGAMENT

    Objective To investigate whether or not posterolateral rotatory instabil ity of the elbow is due to type-I and type-II coronoid process fracture together with anterior bundle of medial collateral l igament (AMCL) injury so as to provide a theoretic basis for its cl inical treatment. Methods Ten fresh-frozen upper extremities were collected from cadavera which was donated voluntarily with no evidence of fracture, dislocation, osteoarthritis, mechanical injury of the surrounding l igament and joint capsule. They included 9 males and 1 female with an average age of 25.1 years (range, 19-40 years), including 3 cases at left sides and 7 cases at right sides. All specimens were transected at the upper midhumeral and carpal levels preserving the distal radioulnar joints to get the bone-l igament specimens. An axial load of 100 N compressing the elbow joint was appl ied along the shaft of the forearm in the sagittal plane through the biomechanical study system. The load-displacement plot was measured and analyzed at elbow flexion of 90, 60, and 45° and under four conditions (intact elbow, type-I coronoid process fracture, type-I coronoid process fracture with AMCL deficient, and type-II coronoid process fractures with AMCL deficient). Results The posterior displacements were maximum at 90° elbow flexion. Hence, the results at 90° elbow flexion were analyzed: under condition of intact elbows, the posterior displacement was the smallest (2.17 ± 0.42) mm and the posterolateral rotatory stabil ity was the greatest; under condition of type-I coronoid process fracture, the posterior displacement was (2.20 ± 0.41) mm, showing no significant difference compared with that of the intact elbow (P gt; 0.05); under condition of type-I coronoid process fracture with AMCL deficient, the posterior displacement was (2.31 ± 0.34) mm, showing no significant difference compared with that of intact elbow (P gt; 0.05); and under condition of type-II coronoid process fracture with AMCL deficient, the posterior displacement was (2.65 ± 0.38) mm, showing a significant difference compared with that of intact elbow (P lt; 0.05). There was no macroscopic ulnohumeral dislocation or radial head dislocation during the experiment. Conclusion An simple type-I coronoid process fracture or with AMCL deficient would not cause posterolateral rotatory instabil ity of elbow and may not need to be repaired. But type-II coronoid process fractures with AMCL deficient can cause posterolateral rotatory instabil ity of elbow, so the coronoid process and the AMCL should be repaired or reconstructed to restore posterolateral rotatory stabil ity as well as valgus stabil ity.

    Release date:2016-08-31 05:47 Export PDF Favorites Scan
  • The past 10 years of clinical trial registration in China: status and challenge

    Since the public clinical trial registration system was launched twelve years ago in China, as the primary register of the WHO International Clinical Trial Registry, the Chinese Clinical Trial Registry (ChiCTR) has largely promoted the development of clinical trial registration in China, particularly in recent three years. The quantity of registered trials has increased rapidly and 3939 studies were registered in ChiCTR in 2017. An increasing number of investigators, Institutional Review Boarders and funding agencies were taking the trial registration into account in the medical research ethics issues these years. Considering the large number of workforce in public health, limited researchers knew clinical trial registration very well, even with misunderstandings. For instance most of them do not know the purpose of trial registration and the principle of local registration. A lot of Chinese medical journals editors have been working together with us to promote the development of clinical trial transparency in last ten years, and they have made outstanding contributions. We would like to appeal more medical journals to join the great revolution of medical research.

    Release date:2018-06-20 02:05 Export PDF Favorites Scan
  • An investigation based on registered clinical trials on Chinese clinical trial registry for exploring the factors of impacting quality of clinical trials

    Objectives To explore potential important factors that impacts the quality of Chinese trials. Methods We randomly selected clinical studies registered in the Chinese Clinical Trial Registry during March 15th, 2016 to December 31st, 2016. The randomized controlled trials protocols were retrieved to assess the quality based on the SPIRIT guideline, their data management plan and statement of sharing individual participant data were also investigated. Results 457 studies were randomly selected from 2 205 studies by a rate of 1∶4. Among them, 393 were randomized controlled trials. Pre-market trials of new medicines conducted by the State Clinical Study Bases had better quality of protocols. In total, 4 protocols were rated as high quality (1.02%) and 21 as higher quality (5.34%). 129 studies in 457 (28.23%) described a correct data management system including a paper case record form and an electronic data capture. 392 studies (85.77%) stated that public sharing IPD will be available. Conclusions Poorly developed protocol and lack of professional data management system are common issues in some Chinese clinical studies. We feel confident that most Chinese investigators are good in learning considering that they are willing to share the IPD of their studies. Providing education and technical support focus on three technical aspects are crucial: introducing SPIRIT for developing protocol, providing standardized data management system, and introducing the concept of transparency include sharing IPD which is an essential requirement of clinical study ethics.

    Release date:2018-06-20 02:05 Export PDF Favorites Scan
  • Analysis of the relationship between venous thromboembolism after surgical treatment for bronchiectasis and preoperative hemoglobin amount

    Objective To study the correlation of preoperative hemoglobin amount with venous thromboembolism (VTE) after surgical treatment of bronchiectasis and the clinical significance. Methods A retrospective study was performed on patients with bronchiectasis who underwent surgical treatment in our center from June 2017 to November 2021. The differences in blood parameters between the VTE patients and non-VTE patients were compared. The relationship between preoperative hemoglobin and VTE was confirmed by quartile grouping and receiver operating characteristic (ROC) curve. Results A total of 122 patients were enrolled, including 50 males and 72 females, with a mean age of 52.52±12.29 years. The overall incidence of VTE after bronchiectasis was 9.02% (11/122). Preoperative hemoglobin amount (OR=0.923, 95%CI 0.870-0.980, P=0.008) and D-dimer amount (OR=1.734, 95%CI 1.087-2.766, P=0.021) were independent influencing factors for VTE after bronchiectasis. The incidence of VTE after bronchiectasis decreased gradually with the increase of preoperative hemoglobin amount. The area under the ROC curve (AUC) of postoperative D-dimer alone was 0.757, whereas the AUC of postoperative D-dimer combined with preoperative hemoglobin amount was 0.878. Conclusion Low preoperative hemoglobin is an independent risk factor for postoperative VTE. Postoperative D-dimer combined with preoperative hemoglobin amount has a better predictive performance compared with postoperative D-dimer alone for postoperative VTE.

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