At present, systematic reviews of animal experimental studies has become a new trend and an important way to synthesize the results of animal experimental studies, improve the conducting and reporting quality of animal experimental studies and provide references for the furture clinical research. However, there are many problems in the design and implementation process of published systematic reviews of animal experimental studies. Therefore, it is important to design a scientific and standard practical process to improve the quality of systematic reviews of animal experimental studies. In this paper, we developed a standard process for systematic reviews of animal experimental studies, in order to improve the quality of systematic reviews of animal experimental studies.