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find Author "陈长征" 69 results
  • 引领创新大家风范——记中山大学中山眼科中心吴乐正教授

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  • 《中华眼底病杂志》2001至2010年刊出论文被引情况分析

    Release date:2016-09-02 05:26 Export PDF Favorites Scan
  • 趋化因子受体3在脉络膜新生血管性疾病中的研究进展

    趋化因子受体3(CCR3)是一种新的趋化因子受体,在一些炎症免疫疾病中发挥重要作用。CCR3在眼部主要分布于视网膜色素上皮细胞中,亦可表达于脉络膜血管内皮细胞中。在一些脉络膜新生血管(CNV)疾病发现CCR3表达;在CNV动物模型中CCR3活化能够促进新生血管形成。通过CCR3抗体和基因敲除方法抑制CCR3和其配体,能够使动物模型中CNV面积明显减小;使用CCR3拮抗剂亦能够显著抑制CNV的体积。进一步深入研究CCR3及其配体生理状态下在眼部的分布和表达,了解其在CNV疾病发生发展中的变化规律及机制,对于CNV形成研究以及寻找CNV形成的检测指标和新一代CNV治疗药物具有积极意义。

    Release date:2016-09-02 05:26 Export PDF Favorites Scan
  • 玻璃体腔注射抗血管内皮生长因子单克隆抗体bevacizumab后视功能的变化

      玻璃体腔注射抗血管内皮生长因子单克隆抗体bevacizumab(商品名:Avastin)后,患眼功能改善或稳定,疗效和安全性良好。其中,视功能变化表现为视力显著提高,对比敏感度稳定不变或明显改善,视网膜电图(ERG)未出现显著改变,多焦视网膜电图(mfERG)反应稳定或改善,眼电图(EOG)和视觉诱发电位(VEP)与治疗前相比无明显改变,视野保持稳定或轻微改善,色觉保持不变。但重复注射、bevacizumab联合其它治疗后的视功能变化以及长期疗效及安全性仍需更加充分的评估依据进行大样本长时间随访研究。

    Release date:2016-09-02 05:37 Export PDF Favorites Scan
  • 玻璃体腔注射抗血管内皮生长因子药物治疗早产儿视网膜病变的研究现状

    与冷冻及激光光凝治疗比较,玻璃体腔注射抗血管内皮生长因子(VEGF)药物治疗早产儿视网膜病变(ROP)可减少对视网膜解剖结构的破坏,促使周边视网膜继续血管化,降低视网膜脱离、视野缺损及高度近视的发生。在ROP 1区病变及屈光间质混浊等激光光凝难以施行的患眼中有其独特优势。选择合理的药物和剂量,掌握最佳治疗时间,注意避免局部并发症及全身安全性等方面的问题,对进一步提高玻璃体腔注射抗VEGF药物治疗ROP的应用水平具有重要意义。

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  • Comparison of 23G and 25G+ vitrectomy for treatment of proliferative diabetic retinopathy

    ObjectiveTo compare the outcomes of 23G and 25G plus (25G+) vitrectomy in treatment of proliferative diabetic retinopathy (PDR). MethodsThis is a prospective randomized study. Fifty-seven PDR patients (75 eyes) with symptoms requiring vitrectomy were randomly divided into 23G vitrectomy group (30 patients, 39 eyes) and 25G+ vitrectomy group (27 patients, 36 eyes). Visual acuity, intraocular pressures, ophthalmoscopy, B-scan ultrasound was examined before surgery. The follow-up period was 10.0 (23G group) and 8.5 months (25G+ group) respectively. Intraoperative complications, operation time, postoperative visual acuity, intraocular pressure, postoperative complications and postoperative ocular conditions were analyzed. ResultsThe mean surgical times were (53.35±7.42) minutes and (49.16±5.17) minutes in 23G and 25G+ group respectively, and the difference was significant (t=4.37, P < 0.05). Iatrogenic injuries occurred in 11 eyes (28.21%) and 5 (13.89%) eyes in 23G and 25G+ group respectively, and the difference was significant (χ2=4.93, P < 0.05). The postoperative visual acuity of 23G and 25G+ group were improved compared to before surgery (χ2=16.81, 18.29; P < 0.05). At last follow-up, there was 25 eyes and 24 eyes with visual acuity≥0.05 in 23G and 25G+ groups respectively, and the difference was not significant (χ2=0.13, P > 0.05). Hypotony was detected in 7 and 3 eyes at the third postoperative day in 23G and 25G+ group respectively, and the difference was significant (χ2=5.67, P < 0.05). Conclusion25G+ vitrectomy is a safe and effective treatment for PDR with shorter surgery time and fewer surgical complications.

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  • 影响渗出型老年性黄斑变性患者玻璃体腔注射雷珠单抗治疗反应的临床特征与基因因素

    玻璃体腔注射雷珠单抗可减少渗出型老年性黄斑变性(wAMD)患者的脉络膜新生血管(CNV)生成,稳定或改善视力。随着临床应用研究的逐渐深入,发现并非所有wAMD患者对玻璃体腔注射雷珠单抗均表现出良好的治疗效果。研究发现,患者基线视力、CNV病灶大小及类型、年龄、玻璃体视网膜黏附状态、疾病的基因特征等均可影响患者对治疗的反应。充分了解影响wAMD患者雷珠单抗治疗反应的相关因素,增强玻璃体腔注射雷珠单抗治疗的针对性,提高其临床应用效果具有重要意义。

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  • 黄斑微囊样水肿的研究现状及进展

    黄斑微囊样水肿(MME)是新近发现于视神经、视网膜相关病变的一种特征性眼底影像表现, 病因与发病机制尚不明确。光相干断层扫描(OCT)检查是目前确诊MME的重要手段。MME的OCT特征主要表现为局限于内核层且边界清楚、囊样腔隙性的弱反射信号区域, 常有内核层水肿及神经节细胞功能损害。激光扫描检眼镜也可用来检测MME, 主要表现为弱信号暗区, 并能清楚直观地显示MME累及范围。MME与多发性硬化、视神经脊髓炎等多种视神经疾病和老年性黄斑变性、黄斑前膜等视网膜疾病有一定相关性。这一新的眼底影像特征对于了解这些视神经、视网膜疾病发病机制或病程进展可能具有一定的参考价值。进一步了解MME的临床特征, 探讨其发病机制及其与视神经、视网膜疾病之间的关系有重要的临床意义。

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  • Improve our understanding of ocular fundus diseases with ultra-wide-field fluorescein angiography

    Ultra-wide-field fluorescein angiography (UWFA) can obtain very wide retinal images (up to 200°), and is a very helpful tool to detect peripheral retinal lesions which cannot be found by other imaging methods. Analyzing the characteristics of the UWFA images may improve our understanding, treatment outcomes and management strategies of ocular fundus diseases. However this technology is still in its premature stage, there is still a lot of work to be done to improve its clinical application and study the characteristics and clinical meanings of these peripheral retinal lesions.

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  • The role of ras homolog family/ras homolog family kinase signaling pathway and its inhibitors in the optic nerve disease

    Ras homolog family (Rho)/ Rho-associated coiled-coil kinase (ROCK) signaling pathway widely exists in human and mammal cells, which is closely related to inhibition of repair after optic nerve damage. The expression level of Rho/ROCK signaling pathway-related proteins is up-regulated in glaucoma, and related with the death of retinal ganglionic cell (RGC) and the axon activity. ROCK inhibitors can protect the surviving RGC and promote axon extension with a dose-dependent manner. ROCK inhibitors also can inhibit glial scar formation, lower intraocular pressure and inhibit inflammatory response to some degrees. Rho/ROCK signaling pathway correlates with the optic nerve disease progression, and ROCK inhibitors hope to become a new therapeutic drug.

    Release date:2017-09-19 03:09 Export PDF Favorites Scan
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