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find Author "陈长征" 70 results
  • 引领创新大家风范——记中山大学中山眼科中心吴乐正教授

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  • The role of ras homolog family/ras homolog family kinase signaling pathway and its inhibitors in the optic nerve disease

    Ras homolog family (Rho)/ Rho-associated coiled-coil kinase (ROCK) signaling pathway widely exists in human and mammal cells, which is closely related to inhibition of repair after optic nerve damage. The expression level of Rho/ROCK signaling pathway-related proteins is up-regulated in glaucoma, and related with the death of retinal ganglionic cell (RGC) and the axon activity. ROCK inhibitors can protect the surviving RGC and promote axon extension with a dose-dependent manner. ROCK inhibitors also can inhibit glial scar formation, lower intraocular pressure and inhibit inflammatory response to some degrees. Rho/ROCK signaling pathway correlates with the optic nerve disease progression, and ROCK inhibitors hope to become a new therapeutic drug.

    Release date:2017-09-19 03:09 Export PDF Favorites Scan
  • 趋化因子受体3在脉络膜新生血管性疾病中的研究进展

    趋化因子受体3(CCR3)是一种新的趋化因子受体,在一些炎症免疫疾病中发挥重要作用。CCR3在眼部主要分布于视网膜色素上皮细胞中,亦可表达于脉络膜血管内皮细胞中。在一些脉络膜新生血管(CNV)疾病发现CCR3表达;在CNV动物模型中CCR3活化能够促进新生血管形成。通过CCR3抗体和基因敲除方法抑制CCR3和其配体,能够使动物模型中CNV面积明显减小;使用CCR3拮抗剂亦能够显著抑制CNV的体积。进一步深入研究CCR3及其配体生理状态下在眼部的分布和表达,了解其在CNV疾病发生发展中的变化规律及机制,对于CNV形成研究以及寻找CNV形成的检测指标和新一代CNV治疗药物具有积极意义。

    Release date:2016-09-02 05:26 Export PDF Favorites Scan
  • Progress in the application of leakage index in retinal diseases

    Retinal leakage is not only a very common pathological phenomenon but also a common pathological feature of many retinal diseases, its pathogenesis is very complex. The application of ultra-wide-angle fluorescein angiography is one of the main means to observe and evaluate retinal leakage. Leakage index is a new index for evaluating retinal leakage. Studies have explored its correlation in diabetic retinopathy, retinal vein occlusion, uveitis and other diseases, evaluating treatment effects and predicting prognosis. However, the number of related studies is small and the conclusions are inconsistent. In the future, it is still necessary to further advance the quantitative analysis of leakage, the application of leakage in more diseases, and the clinical trials of leakage rate to explore its role in predicting and evaluating treatment effects in retinal diseases.

    Release date:2022-08-16 03:23 Export PDF Favorites Scan
  • Progress in diagnosis and treatment of adult Coats disease

    Adult Coats disease is characterized by abnormal expansion of retinal capillaries, often accompanied by massive lipid exudation and exudative retinal detachment. Unlike Coats disease in young children, adult Coats disease is mostly limited to peripheral retina, with slow progress and better prognosis. Adult Coats disease should be identified with Coats-like diseases such as exudative age-related macular degeneration, diabetic retinopathy, obsolete retinal vein occlusion, idiopathic macular telangiectasia 1, obsolete posterior uveitis, retinal vasculitis, or acute retinal necrosis. Because the pathogenesis of Coats disease is not clear, it lacks specific treatment measures for the cause of disease. The purpose of simple or combined laser photocoagulation, freezing, vitreous intravitreal injection against vascular endothelial growth factor drugs or triamcinolone and surgery is to eliminate abnormal blood vessels and exudation, maintain visual function, which can also improve retinal detachment and prevent neovascular glaucoma and other complications. To explore the similarities and differences of adult Coats disease with Coats disease in young children, to further promote the study of the pathogenesis of adult Coats disease and to provide new targets for its treatment are the direction of future research.

    Release date:2018-05-18 06:38 Export PDF Favorites Scan
  • The status and advances in the application of choroidal vascular index in fundus diseases

    The choroidal vascular index (CVI) is the ratio of the luminal area to the total choroidal area. It can not only reflect the changes in the vascular composition of the choroid, but also serve as an observation index for follow-up treatment effects. CVI is a new biometric tool, which is gradually applied to the observation of choroidal structure in various eye diseases. It has great application prospects in the study of pathophysiological mechanisms, disease process monitoring and efficacy evaluation such as central serous chorioretinopathy, polypoid choroidal vascular disease, age-related macular degeneration, diabetic retinopathy,etc. Understanding the research progress of CVI in various eye diseases can provide reference for clinical research of CVI.

    Release date:2020-12-18 07:08 Export PDF Favorites Scan
  • Outer retinal tubulations

    Outer retinal tubulations (ORT) are tubular structures that are visualized on spectral domain optical coherence tomography in single B-scans as nonedematous circular or ovoid structures at the level of the outer nuclear layer. It is most commonly seen in exudative age-related macular degeneration and pseudoxanthoma elasticum, as well as in multifocal choroiditis, panuveitis, geographic atrophy, central serous chorioretinopathy, polypoid choroidal neovascularization, choroideremia and some other diseases related to outer retinal structural damage. ORT is the structure of dislocation junction of outer membrane and ellipsoid band in the process of self-repair after destroyed. Cystoid retinal edema, subretinal fluid and photoreceptor layer damage are important factors for ORT formation. Anti-vascular endothelial growth factor (VEGF) drugs cannot make ORT disappear, and distinguishing between ORT and retinal cystoid edema is helpful to avoid unnecessary anti-VEGF treatment. ORT has a certain predictive value for the prognosis of vision, and has guiding significance for clinical treatment. However, the mechanism of ORT formation and its relationship with clinical practice are not yet fully understood. More advanced imaging equipment and a large number of cases are needed to study the formation of ORT and its relationship with classical choroidal neovascularization, retinal fibrous scarring and retinal atrophy.

    Release date:2018-09-18 03:28 Export PDF Favorites Scan
  • 玻璃体腔注射抗血管内皮生长因子药物治疗早产儿视网膜病变的研究现状

    与冷冻及激光光凝治疗比较,玻璃体腔注射抗血管内皮生长因子(VEGF)药物治疗早产儿视网膜病变(ROP)可减少对视网膜解剖结构的破坏,促使周边视网膜继续血管化,降低视网膜脱离、视野缺损及高度近视的发生。在ROP 1区病变及屈光间质混浊等激光光凝难以施行的患眼中有其独特优势。选择合理的药物和剂量,掌握最佳治疗时间,注意避免局部并发症及全身安全性等方面的问题,对进一步提高玻璃体腔注射抗VEGF药物治疗ROP的应用水平具有重要意义。

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  • Strengthen the construction of tertiary prevention and treatment network of retinopathy of prematurity in China

    The prevention and treatment of retinopathy of prematurity (ROP) is an important strategic content of blindness prevention and treatment in China. Medical institutions including remote areas have strengthened the awareness of neonatal fundus screening, however, there are problems of vague screening standards, mainly manifested in expanding the scope of screening and even universal screening of newborns. At the same time, all kinds of fundus changes found in the examination cannot be correctly interpreted and handled, which increase the economic and psychological burden of children's families. In addition, with the wide application of intravitreal injection of anti-neovascular endothelial growth factor, problems such as improper grasp of indications and improper treatment of complications have become increasingly prominent. At this stage, it is urgent to strengthen the construction of ROP prevention and control network, which is suitable for China's national conditions, led by the government and coordinated participation of health and medical institutions at all levels.

    Release date:2022-08-16 03:23 Export PDF Favorites Scan
  • 玻璃体腔注射抗血管内皮生长因子单克隆抗体bevacizumab后视功能的变化

      玻璃体腔注射抗血管内皮生长因子单克隆抗体bevacizumab(商品名:Avastin)后,患眼功能改善或稳定,疗效和安全性良好。其中,视功能变化表现为视力显著提高,对比敏感度稳定不变或明显改善,视网膜电图(ERG)未出现显著改变,多焦视网膜电图(mfERG)反应稳定或改善,眼电图(EOG)和视觉诱发电位(VEP)与治疗前相比无明显改变,视野保持稳定或轻微改善,色觉保持不变。但重复注射、bevacizumab联合其它治疗后的视功能变化以及长期疗效及安全性仍需更加充分的评估依据进行大样本长时间随访研究。

    Release date:2016-09-02 05:37 Export PDF Favorites Scan
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