目的:探讨开颅夹闭和血管内栓塞治疗颅内动脉瘤的效果比较及并发症。方法:从2003~2008年近五年来我院收治的颅内动脉瘤54例,其中开颅夹闭24例(Hunt Hess分级Ⅰ~Ⅱ级20例,Ⅲ级2例,Ⅳ级2例),共26个动脉瘤。血管内栓塞30例(HuntHess分级Ⅰ~Ⅱ级23例,Ⅲ级5例,Ⅳ级2例),共31个动脉瘤。临床结果按GOS进行评价。结果:两组的良好率、并发症及死亡率无显著差别(Pgt;0.05)。随访平均12月,Ⅰ~Ⅱ级动脉瘤患者治疗良好率为100.0%(43/43),并发症发生率为4.7%(2/43),Ⅲ~Ⅳ级者分别为18.2%(2/11)和90.9%(10/11),两者相差显著(Plt;0.05)。结论:开颅夹闭和血管内栓塞治疗颅内动脉瘤,二者疗效相仿,各有优缺点。动脉瘤患者病情级别越高,治疗效果越差。
目的 探讨白细胞介素1α(IL-1α)基因多态性与颅内动脉瘤发生的关系。 方法 以2010年6月-2012年3月145例颅内动脉瘤患者和181例正常对照者为研究对象,采用聚合酶链反应-限制性片段长度多态性检测IL-1α-889C/T和+4845G/T多态性,统计分析基因多态性与颅内动脉瘤的相关性。 结果 IL-1α-889C/T位点:CT/TT基因型在颅内动脉瘤组中的频率为32.4%,显著高于其在对照组中的频率(21.5%),两组相比差异有统计学意义(χ2=4.90,P<0.05);T等位基因在颅内动脉瘤组中的频率为16.9%,显著高于其在对照组中的频率(10.8%),两组相比差异有统计学意义(χ2=5.17,P<0.05)。IL-1α+4845G/T多态性在两组人群中的分布差异无统计学意义(P>0.05)。 结论 IL-1α -889C/T多态性与颅内动脉瘤的发病有关,-889T等位基因可能是颅内动脉瘤的遗传易感基因。
ObjectiveTo investigate the efficacy of stellate ganglion block (SGB) on postoperative palpebral edema in patients undergoing intracranial aneurysm surgery. MethodsSixty patients who were scheduled to undergo intracranial aneurysm surgery between September 2012 and Novermber 2014 were recruited, and were assigned into 2 groups randomly with 30 in each:SGB group and control group. Patients in SGB group were administered SGB by injecting 0.3% ropivacaine on the operative side under the ultrasound guidance after surgery completed, while patients in the control group received injection of saline on the operative side under the ultrasound guidance. Incidence of postoperative palpebral edema at hour 24, 48, and 72 after surgery were measured. Numerical rating scale (NRS) was used to detect the severity of uncomfortable symptoms for palpebral swelling during rest state. The severity of palpebral edema was evaluated with continuous rating scale (0-5, 0 indicated normal palpebral, and higher score indicated more serious palpebral edema). Complications related with SGB were recorded. ResultsThe overall incidence of palpebral edema at hour 24 after surgery in SGB group was lower than that in the control group (P<0.05). There was no statistically significant difference in the overall incidence of palpebral edema at hour 48 and 72 after surgery between the two groups (P>0.05). The palpebral edema rating scores of the SGB group at hour 24 after surgery were lower than those of the control group (P<0.01).The incidence of palpebral edema which was scored 3 or more at hour 24 and 48 after surgery in SGB group was lower than that in the control group (P<0.05). No statistically significant difference was found in the incidence of palpebral edema which was scored 3 or more at hour 72 after surgery between the two groups (P>0.05). No complication related with SGB was found. ConclusionSGB can safely reduce the incidence of postoperative palpebral edema in patients undergoing intracranial aneurysm surgery, and reduce the severity of palpebral edema.
目的 分析颅内动脉瘤弹簧圈栓塞治疗术中出血的原因和防治对策。 方法 回顾性分析2003年3月-2012年8月358例颅内动脉瘤采用弹簧圈栓塞治疗患者,7例弹簧圈栓塞过程中出血,并继续栓塞止血。2例为弹簧圈栓塞中造影仅见血流明显变慢,术后CT证实的出血。术后对症治疗6例,开颅引流减压3例。 结果 9例术中破裂者中8例致密栓塞,1例部分栓塞。5例恢复好,1例一过性动眼神经麻痹,3例死于颅内高压 结论 术中出血与手中操作、动脉瘤形态和患者血管条件、血压变化有关,继续填塞及合理术中与后续治疗可以挽救大部分患者生命。
目的:探讨血管内Neuroform支架置入联合弹簧圈栓塞治疗颅内复杂动脉瘤的疗效、技术要点、安全性及并发症防治。方法: 研究对象为20例颅内复杂动脉瘤患者,其中颈内动脉海绵窦段4例,眼动脉段3例,后交通动脉段7例,脉络膜前动脉起始部1例,大脑中动脉M1段1例,椎动脉颅内段4例。首先将微导管置入瘤腔,然后跨瘤颈释放支架,栓塞弹簧圈。结果: 所有病例栓塞操作均顺利完成。其中致密栓塞13例,大部分栓塞7例;术后脑梗塞1例,1个月后恢复;2例弹簧圈尾端疝入载瘤动脉,均未引起相应的临床症状。随访3~24个月,平均13个月,无再出血及血栓栓塞症状。结论: 血管内支架植入联合弹簧圈治疗颅内复杂动脉瘤安全有效。