目的探讨下肢深静脉血栓形成(DVT)的治疗方法及经验。方法分析我院2007年1月至2010年1月期间237例DVT患者的临床资料,其中行以抗凝、祛聚为主的非手术治疗198例,行介入手术治疗39例。结果198例给予抗凝、祛聚为主的非手术治疗者中临床治愈85例(42.93%),有效108例(54.55%),无效5例(2.52%); 39例给予介入手术治疗(均先行下腔静脉滤器置入,然后行球囊导管取栓治疗33例,行介入溶栓6例)者均临床治愈(100%)。总有效率为97.89%(232/237)。对39例行介入手术治疗患者术后随访3~24个月(平均10个月),2例患者出现下腔静脉阻塞并发下肢DVT,经抗凝、祛聚等治疗后症状缓解; 均未见滤器移位、肺栓塞等并发症。结论DVT患者介入治疗效果优于非手术治疗,早期诊断和合理的治疗方案是DVT治疗成功的关键。
目的总结坏死性筋膜炎的特点和治疗方法。 方法回顾性分析北京协和医院2000年2月至2014年3月期间所收治的20例坏死性筋膜炎病例的临床资料。 结果20例患者中男15例,女5例,男女比例3:1;发病年龄(52.3±11.0)岁(39~76岁);病变部位双下肢11例,肛周7例,腹部切口1例,颈部1例。15例存在合并症,其中合并糖尿病7例。共18例患者接受手术,行1次手术者6例,2次及以上手术者12例,其中手术次数最多者达21次;另有1例患者因病重无手术机会而死亡,1例患者放弃抢救。共10例患者接受输血治疗。20例患者中好转13例(65%),转院2例(10%),死亡或放弃抢救治疗5例(25%)。 结论坏死性筋膜炎进展迅速,早期诊断较难,死亡率较高。彻底清创是最重要的治疗手段,多数患者需要多次手术来控制疾病的进展。
Objective To explore the preventive effectiveness of early physiotherapy on arm lymphedema after modified radical mastectomy for breast cancer. Methods A total of 206 patients who underwent modified radical mastectomy for breast cancer in The First Affiliated Hospital of Henan University from June 2014 to June 2016, enrolled in this randomized controlled clinical trial. Then these patients were randomly divided into intervention group and control group equally. Patients in the control group received routine treatment, and the patients in the intervention group began to use the air pressure pump combined with the microwave physiotherapy on the second day after the radical surgery. The incidences of limb lymphedema in 6 months and 1 year after operation between the 2 groups were compared, and the influencing factors of arm lymphedema were explored. Results The clinical data of 195 patients were analyzed at end, including 99 patients of the intervention group and 96 patients of the control group. ① There were statistical significance in the incidences of arm lymphedema in 6 months and 1 year after operation between the 2 groups (P<0.05), that incidences of arm lymphedema in the intervention group were both lower than those of the control group at the2 time points [6 months after operation: 2.0% (2/99)vs. 9.4% (9/96); 1 year after operation: 5.1% (5/99) vs. 17.7% (17/96)]. ② The results of non-conditional logistic regression analysis shown that, age (OR=1.45, P=0.008), tumor location (OR=1.72, P<0.001), TNM stage (OR=2.01, P=0.033), the number of invasive axillary lymph nodes (OR=1.15, P=0.005), and postoperative radiotherapy (OR=1.23, P=0.016) were the influencing factors of arm lymphedema after modified radical mastectomy for breast cancer, patients with age older than 60 years, tumor position at the outside area, stage Ⅲ of TNM, the number of invasive axillary lymph nodes >5, and patients received radiotherapy after operation had high risk of arm lymphedema. Conclusion Early physiotherapy can effectively prevent the occurrence of arm lymphedema after modified radical mastectomy for breast cancer, and early physiotherapy should be performed for patients with high risk of arm lymphedema.