目的 探讨腹腔镜胆囊切除术(LC)同时同孔完成多脏器手术可能性及手术方法。方法 总结1993年3月至1999年4月完成LC 2 170例，其中LC同时同孔完成多脏器手术51例。结果 该51例手术全部成功，无1例术中中转开腹，除1例患者LC同时同孔行绝育手术后怀孕，其余无术中及术后并发症发生。结论 LC同时同孔完成多脏器手术实现了跨区域、多脏器同期手术，虽创伤范围增多，操作有一定的难度，仍具有微创外科的特点。一次完成多种手术，不明显增加患者的痛苦及费用，避免了患者在一种疾病治愈后再次住院手术治疗另一种疾病。
Objective To investigate the frequency of variant at XmnⅠ, MspⅠ sites of apolipoprotein (Apo) AⅠ-CⅢ-AⅣ gene cluster and its relation to cholesterol cholecystolithiasis in Chinese population. Methods The restriction fragment length polymorphisms (RFLP) at Xmn Ⅰ, MspⅠ sites of ApoAⅠ-CⅢ-AⅣ gene cluster was studied by using polymerase chain reaction (PCR) in healthy subjects (control group) and patients with gallstones(gallstone group) from a population of Chinese with the Han nationality in Sichuan Province. Results The X1, M1 alleles were the major alleles in both gallstone group and control group, and X1X1, M1M homozygous genotypes were the most frequent ones. The frequencies of X1X2, X2X2 and X2 alleles in female patients of the gallstone group were significantly higher than those in female of control group (P＜0.05), and the frequencies of X1X1 and X1 alleles in control group were significantly higher than those in gallstone group (P＜0.05). The frequencies of M1M1 in male patients of the gallstone group were significantly lower than those in male of control group (P＜0.05), whereas, the frequencies of M1M2 were significantly higher in gallstone group (P＜0.05). Conclusion The polymorphism of XmnⅠ RFLP of ApoAⅠ-CⅢ-AⅣ gene cluster in female and the polymorphism of MspⅠ RFLP of ApoAⅠ-CⅢ-AⅣ gene cluster in male may be associated with cholesterol cholecystolithiasis in Chinese population.