west china medical publishers
Author
  • Title
  • Author
  • Keyword
  • Abstract
Advance search
Advance search

Search

find Author "马琳" 11 results
  • 大肠癌肝转移患者的术中超声特征的差异性

    Choti MA,Kaloma F,de Oliveira ML等人对99例大肠癌肝转移行肝切除术患者的术中超声图像进行回顾性分析,评估肿瘤转移灶术中B超回声在不同患者间的差异性。结果显示,大肠癌肝转移灶超声表现为低回声者占总病例的52.0%,等回声者占35.7%,高回声者占12.3%,大多数患者表现为均质回声(50.8%),少数呈“靶征”、“牛眼征”(20%)或伴有钙化(19%),其临床病理特征与超声表现无相关性,同一患者的肝转移灶术中超声特征比不同患者间更为相似,其结果提示超过一处转移的患者,可以由一个病变指标的回声表现推断其他隐匿性疾病〔Arch Surg, 2008-01; 143(1)∶29-34〕。

    Release date:2016-09-08 11:47 Export PDF Favorites Scan
  • Features and progress of metadata standards of clinical research

    A metadata standard is a high level document that establishes a common way of structuring and understanding data, and includes principles and implementation issues for utilizing the standard. It helps to record their collections and processes and to structure this information, and can be used to validate data integrity and quality. Metadata standards improve the quality and interoperability of information across information technology platforms by increasing compatibility, improving the consistency and efficiency of information collection, and reducing redundancy. This article introduced the progress and features of metadata standards of clinical research, and aimed to promote the standardization of clinical research and scientific process of therapeutic evaluation.

    Release date: Export PDF Favorites Scan
  • 肺癌组织中hMLH1基因的表达及其临床意义

    目的 了解错配修复基因hMLH1蛋白在肺癌组织中的表达情况。方法 应用免疫组织化学SP法对60例肺癌组织中hMLH1蛋白的表达进行检测。结果 60例肺癌组织中35例hMLH1蛋白表达阳性(58.3%)。伴有淋巴结转移者肺癌组织中hMLH1的阳性率(31.8%)低于无淋巴结转移者(P<0.05);临床Ⅲ~Ⅳ期肺癌组织中hMLH1的阳性率(34.8%)低于Ⅰ~Ⅱ期(P<0.05);肺鳞癌hMLH1的阳性率(46.2%)低于肺腺癌(P<0.05);hMLH1基因的表达在肺癌组织不同病理分化程度者间差别无显著性意义。结论 hMLH1基因可能参与了肺癌的发生和发展过程,尤其在肺鳞癌的发生和发展中可能起更为重要的作用。hMLH1的表达多发生于晚期肺癌及伴有淋巴结转移的病例,hMLH1蛋白的检测有助于肺癌的辅助诊断及估计预后。

    Release date:2016-08-30 06:34 Export PDF Favorites Scan
  • Efficacy and safety of plasminogen activator assist external ventricular drainage in cerebral hemorrhage: a systematic review

    ObjectivesTo systematically review the efficacy and safety of plasminogen activator assist external ventricular drainage in cerebral hemorrhage.MethodsPubMed, EMbase, The Cochrane Library, CNKI, VIP, CBM and WanFang Data databases were electronically searched to collect randomized controlled trials (RCTs) on the efficacy and safety of plasminogen activator assist external ventricular drainage in cerebral hemorrhage from inception to March 2019. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies, then, meta-analysis was performed by using RevMan 5.3 software.ResultsA total of 23 RCTs involving 1 560 patients were included. The results of meta-analysis showed that, compared with the blank control or placebo, the addition of plasminogen activator urokinase after puncture and drainage could improve the clinical efficacy (RR=1.36, 95%CI 1.26 to 1.47, P<0.000 01), shorten removal time of hematoma (MD=−3.37, 95%CI −3.89 to −2.85, P<0.000 01), reduce postoperative re-bleeding rate (Peto OR=0.30, 95%CI 0.18 to 0.51, P<0.000 01), reduce the incidence of intracranial infection (Peto OR=0.47, 95%CI 0.25 to 0.87, P=0.02), and reduce mortality (Peto OR=0.45, 95%CI 0.27 to 0.76, P=0.003). The differences were statistically significant between two groups.ConclusionsCurrent evidence shows that the combination with urokinase can improve curative effect of hypertension cerebral hemorrhage patients with external ventricular drainage. In reducing hemorrhage, intracranial infection and mortality, urokinase also has great curative effect. Due to limited quality and quantity of the included studies, more high quality studies are required to verify above conclusions.

    Release date:2019-09-10 02:02 Export PDF Favorites Scan
  • Optimization of pulmonary ultrasound in ultra-fast-track anesthesia for congenital heart disease surgery: A randomized controlled trial

    ObjectiveTo investigate the effect of pulmonary ultrasound on pulmonary complications in ultra-fast-track anesthesia for congenital heart disease surgery.MethodsIn 2019, 60 patients with congenital heart diseases underwent ultra-fast-track anesthesia in Shenzhen Children's Hospital, including 34 males and 26 females with the age ranging from 1 month to 6 years. They were randomly divided into a normal group (group N, n=30) and a lung ultrasound optimization group (group L, n=30). Both groups were used the same anesthesia method and anesthetic compatibility. The group N was anesthetized by ultra-fast-track, the tracheal tube was removed after operation and then the patients were sent to the cardiac intensive care unit (CCU). After operation in the group L, according to the contrast of pre- and post-operational lung ultrasonic examination results, for the patients with fusion of B line, atelectasis and pulmonary bronchus inflating sign which caused the increase of lung ultrasound score (LUS), targeted optimization treatment was performed, including sputum suction in the tracheal tube, bronchoscopy alveolar lavage, manual lung inflation suction, ultrasound-guided lung recruitment and other optimization treatments, and then the patients were extubated after lung ultrasound assessment and sent to CCU. The occurrence of pulmonary complications, LUS, oxygenation index (OI), extubation time, etc were compared between the two groups.ResultsCompared with the induction of anesthesia and 1 hour after extubation of the two groups, the incidence of pulmonary complications in the group L (18 patients, 60.0%) was lower than that in the group N (26 patients, 86.7%, χ2= 4.17, P=0.040) and the rate of patients with LUS score reduction was higher in the group L (15 patients, 50.0%) than that in the group N (7 patients, 23.3%, χ2=4.59, P=0.032). The correlation analysis between the LUS and OI value of all patients at each time point showed a good negative correlation (P<0.05). Extubation time in the group L was longer than that in the group N (18.70±5.42 min vs. 13.47±4.73 min, P=0.001).ConclusionUltra-fast-track anesthesia for congenital heart disease can be optimized by pulmonary ultrasound examination before extubation, which can significantly reduce postoperative pulmonary complications, improve postoperative lung imaging performance, and help patients recover after surgery, and has clinical application value.

    Release date: Export PDF Favorites Scan
  • Arbutin alleviates LPS-induced acute lung injury in mice through PI3K/Akt/mTOR signaling pathway

    ObjectiveTo investigate the protective effect and mechanism of arbutin on LPS induced Acute lung injury in mice. Methods SPF BCLB/C mice were randomly divided into control group, model group,arbutin group, and arbutin+PI3K inhibitor group.arbutin group and arbutin+PI3K group were intervened with corresponding drugs respectively; Constructing an ALI model by intranasal instillation of LPS into mice; After modeling for 6 hours, the mice were killed. After staining the lung tissue slices, observe the pathological changes of the lung tissue and evaluate the lung injury score, and calculate the wet to dry weight ratio (W/D); ELISA method was used to determine the levels of TNF-a and IL-6 in serum and bronchoalveolar lavage fluid (BALF); Measure the ROS content, MDA level,and MPO activity in the lungs; Western blot method was used to detect the expression of PI3K/Akt/mTOR pathway related proteins and autophagy related proteins Beclin-1 and LC3II/I. ResultsCompared with the control group, the pathological changes in the lung tissue of model group mice worsened, and the W/D and lung injury scores increased, The levels of IL-6 and TNF-a in BALF and serum was increased, The ROS content, MDA expression and MPO activity in the lungs was increased,the expression of Beclin-1 and LC3II/I in the lungs was increased. The expression of PI3K/Akt/mTOR pathway related proteins in the lungs decreased (P<0.05). Compared with the model group, the pathological changes in the lung tissue of arbutin group mice were alleviated, with a decrease in W/D and lung injury score, The levels of IL-6 and TNF-a in BALF and serum decrease,ROS content, MDA expression and MPO activity in lung were decreased.The expression of PI3K/Akt/mTOR pathway related proteins in the lung was increased, The expression of Beclin-1 and LC3II/I decreased. However, the appeal performance was partially blocked in the arbutin+PI3K group after the administration of LY294002.ConclusionsArbutin regulates autophagy through PI3K/Akt/mTOR pathway to inhibit inflammatory response and oxidative stress in LPS-induced ALI mice, and plays a protective role in LPS-induced ALI.

    Release date: Export PDF Favorites Scan
  • Experimental Study of Intrahepatic Biliary Perfusion by Contrast Enhanced Ultrasonography via Bile Duct

    ObjectiveTo explore the possibility of intrahepatic biliary perfusion by contrast enhanced ultrasonography via bile duct. MethodsSixteen rabbits weighing 2 000-2 500 g were studied. A 22 gauge catheter was inserted in the common bile duct by surgery. The rabbits were divided into 4 groups according to the concentration of contrast agent, including group A:1/100 of standard concentration; group B:1/200 of standard concentration; group C:1/400 of standard concentration; and group D:1/800 of standard concentration. We observed the filling status, presence of outflow of contrast enhanced signal and satisfactory enhanced time after the injection of contrast agent via the catheter in common bile duct. ResultsFive milliliter of contrast agent was injected in each rabbit. The number of homogeneous filling in group A, B, C and D was 4, 4, 3 and 0 respectively. The number of presence of outflow of contrast enhanced signal in group A, B, C and D was 4, 1, 0 and 0 respectively. The satisfactory enhanced time in group A, B, C and D was (340±29) s, (284±37) s, (82±8) s and 0 s respectively. There was no statistical difference in the satisfactory enhanced time between group A and B (P=0.06) while significant difference in the satisfactory enhanced time between group A and C (P < 0.01), and between group B and C (P < 0.01) was found. ConclusionIt is possible to perfuse the intrahepatic biliary system by sonographic contrast agents via bile duct, and 1/200 of standard concentration is a proper concentration of contrast agent to achieve satisfactory imaging.

    Release date: Export PDF Favorites Scan
  • Analysis of Risk Factors for Retinopathy in Patients with Type 2 Diabetes

    ObjectiveTo investigate the risk factors for retinopathy in type 2 diabetes patients. MethodsA total of 112 patients with type 2 diabetes treated between December 2009 and December 2012 were divided into two groups. Fifty-two patients had no diabetic retinopathy (NDR group) and 60 had diabetic retinopathy (DR group). Blood pressure, blood lipids, and blood glucose were detected to analyze the correlation of retinopathy with disease course, blood pressure, blood lipid, and blood sugar. ResultsDisease course was longer and blood glucose level was higher in DR group than in NDR group (P<0.05). Logistic regression analysis results showed that the incidence of retinopathy was correlated with blood glucose[OR=1.490, 95% CI (1.123, 1.976), P=0.006] and disease course[OR=2.207, 95% CI (1.579, 3.085), P=0.000]. ConclusionBlood glucose and disease course may be the risk factors for DR. Active control of the blood glucose can be benefit for the prevention and treatment of DR.

    Release date: Export PDF Favorites Scan
  • Systematic evaluation and meta-analysis of repeated transcranial magnetic stimulation for epilepsy

    ObjectiveTo systematically evaluate the effect of repeated transcranial magnetic stimulation (rTMS) in treating epilepsy.MethodsThe randomized controlled trials (RCTs) of rTMS for epilepsy and related diseases were collected from PubMed, EMbase, Cochrane Library, CBM, CNKI, VIP, and Wanfang databases by computer. The retrieval time was from establishment to June 2019. Two researchers independently screened the literature, extracted the data and evaluated the deviation risks of the included studies. RevMan5.3 software was used for Meta analysis.ResultsA total of 21 RCTs were included, including 1 587 patients. The results showed that rTMS assisted antiepileptics drugs (AEDs) could improve the effective rate of epilepsy treatment [RR=1.28, 95% CI (1.19, 1.37)], significantly reduced HAMA, HAMD and NFDS scores in the treatment of patients with epilepsy combined with anxiety and depression [MD=−3.94, 95% CI (−4.25, −3.63)], and improve DQ and GMFM-88 scores in children with cerebral palsy combined with epilepsy [MD=7.95, 95% CI (7.00, 8.90)]. In addition, using rTMS will not cause additional adverse reaction [peto OR=0.52, 95% CI (0.31, 0.84)].ConclusionsThe current evidence showed that rTMS combined AEDs can improve the efficient of AEDs therapy. When treat anxiety depression comorbidity, it can significantly reduce the anxiety depression score. In addition in children with cerebral palsy merger, it can improve muscle strength and development. And rTMS will not cause additional adverse reactions. Limited by the quantity and quality of the selected studies, the conclusions need to be verified by more high-quality studies.

    Release date:2019-11-14 10:46 Export PDF Favorites Scan
  • 新型冠状病毒疫苗与癫痫相关研究进展

    新型冠状病毒肺炎(Coronavirus disease 2019,COVID-19)目前仍在世界范围内呈现大流行的趋势,随着病毒的肆意蔓延及迅速变异,针对新冠病毒的疫苗研发工作也在不断深入。癫痫患者作为新冠疫苗的慎用人群,其适用条件的探究也在随着患者需求的增加而日渐清晰。目前已有相关指南对癫痫患者能否接种新冠疫苗给出初步建议,但针对患者个体情况的具体应用条件尚未明确。现有研究表明,目前已上市投入使用的疫苗中,接种后的神经系统不良反应虽存在,但癫痫患者并非疫苗接种的绝对禁忌人群。本文主要就新型冠状病毒疫苗针对癫痫患者的具体适用条件及相关建议作一综述。

    Release date:2021-06-24 01:26 Export PDF Favorites Scan
2 pages Previous 1 2 Next

Format

Content