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find Author "魏世辉" 62 results
  • 颈动脉狭窄引起的眼部缺血性病变

    颈动脉狭窄是缺血性脑病、缺血性眼病的重要原因之一,可以导致多种眼缺血性疾病。急性期常表现为一过性黑曚、视网膜中央动脉和分支动脉阻塞;慢性期常表现为静脉淤滞性视网膜病变、眼缺血综合征,后者可引发新生血管性青光眼。颈动脉超声或头颅磁共振血管成像、CT 血管造影检查、数字减影血管造影检查有利于明确诊断,确定颈动脉狭窄程度超过70%的患者宜行颈动脉内膜切除术或颈动脉支架成形术治疗。眼科医生发现患者有眼部缺血性病变时,要考虑到患者有颈动脉狭窄的可能,并选用合理的检查项目明确诊断,以便使患者得到及时的专科治疗。 (中华眼底病杂志,2007,23:222-224) 

    Release date:2016-09-02 05:48 Export PDF Favorites Scan
  • 追忆缅怀眼血管循环研究的先驱Sohan Singh Hayreh教授

    Release date:2023-06-16 05:21 Export PDF Favorites Scan
  • The progress in clinical applications of monoclonal antibodies in the treatment of neuromyelitis optica spectrum disorder

    Neuromyelitis optica spectrum disorder (NMOSD) is a kind of demyelinating disease of central nervous system which mainly affect optic nerve and spinal cord. Because of its serious blindness and disability, how to effectively prevent relapse has become the focus of ophthalmologists. With the deep understanding of the pathogenesis and the progress of scientific and technological means, more and more monoclonal antibodies(mAb) continue to enter clinical trials. B cell surface antigen CD20 blocker, rituximab, has become a first-line drug for the treatment of NMOSD. CD19 blocker, inebilizumab, can reduce the recurrence and disability of NMOSD patients. The addition of interleukin 6 receptor blocker, satralizumab, and complement C5 inhibitor, eculizumab, reduce the recurrence. Some mAbs such as natalizumab and alemtuzumab may not be effective for the treatment of NMOSD. The expansion of mAb treatment indications and the launch of new drugs still require more clinical trials which are large-scale and international cooperation. At the same time, its potential adverse events and cost issues cannot be ignored.

    Release date:2021-04-19 03:36 Export PDF Favorites Scan
  • Related research progress of neuromyelitis optica

    Neuromyelitis optica (NMO) is an autoimmune inflammatory diseases of the central nervous systems (CNS) mainly affecting the optic nerves and spinal cord. It has the characteristics of high recurrence rate and poor prognosis. NMO related optic neuritis is a common neuro-ophthalmic disease which often results in permanent visual loss or even blindness. Aquaporin 4 (AQP4) antibody is a specific and pathogenic autoantibody in NMO patients. Although AQP4 is expressed in multiple tissues, NMO pathology is remarkably limited to the CNS. Corticosteroids and other immunosuppressive drugs are the standard managements for NMO patients, in order to reduce the relapses and the severity of the acute attack. Multiple avenues of investigation in the laboratory have significantly advanced our understanding of NMO pathophysiology, which is helpful for our understanding of immunologic and nonimmunologic mechanisms. Many offer significant means for NMO therapy by selectively targeting pathways. In the future, moving these agents from the bench to the bedside offers the opportunity to identify safe and effective therapies that limit CNS injury and preserve visual function.

    Release date:2019-01-19 09:03 Export PDF Favorites Scan
  • 光相干断层扫描技术在神经眼科应用的现状

    光相干断层扫描(OCT)技术在神经眼科的应用日益广泛。研究发现, 视神经炎(ON)、非动脉炎性前部缺血性视神经病变及外伤性视神经病变视盘周围神经纤维层(RNFL)厚度均变薄。遗传性视神经病变视盘RNFL厚度变薄部位局限在颞侧; 黄斑部视网膜厚度变薄部位发生在鼻侧, 与盘斑束位置一致。随着高清OCT的普及, 黄斑部神经节细胞复合体(GCC)的变化在神经眼科疾病的意义也日益受到重视, 已有研究发现, GCC与ON视功能预后密切相关。神经眼科疾病的这些OCT特征将为其诊断及鉴别诊断带来更多帮助。

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  • Enhance the awareness of neuromyelitis optica-related optic neuritis to improve early diagnosis and treatment outcomes

    Neuromyelitis optica-related optic neuritis (NMO-ON) is a kind of severe optic nerve disease, which always leads to replase, poor prognosis, and even blindness. Aquaporin 4 antibody (AQP4-IgG) is the main diagnostic biomarker for neuromyelitis optica with high specificity. Serum myelin oligodendrocyte glycoprotein antibody (MOG-IgG) is helpful for the diagnosis of AQP4-IgG negative patients. The study of biomarkers is helpful to deeply understand the pathogenesis of NMO-ON, help the diagnosis of the disease, and finally make precise treatment. Orbital MRI can help to differentiate MOG-IgG positive from AQP4-IgG positive neuromyelitis optica and optic neuritis, which is very important for the diagnosis of NMO-ON. At present, the standardized treatment of NMO-ON can be divided into two clinical stages: acute stage and remission stage. Corticosteroids and plasma exchange are the main treatments in acute stage, aiming at alleviating acute inflammatory reaction and improving prognosis. Immunosuppressive agents and biological agents are the main treatments in remission stage, aiming at preventing or reducing recurrence. With the development of the diagnosis and treatment of NMO-ON, we find that it is more and more important to strengthen the construction of neuro-ophthalmology team in China, establish clinical epidemiological database of NMO-ON, and carry out multi-centre, large-sample, prospective clinical control studies in China to provide evidence-based medicine for Chinese people. In addition, we need to strengthen efforts to establish and improve the diagnostic criteria for NMO-ON and the promotion of diagnostic and therapeutic criteria, and strive to improve the clinical diagnosis and treatment level of NMO-ON in China.

    Release date:2019-05-17 04:15 Export PDF Favorites Scan
  • 颈动脉狭窄致眼部缺血疾病的临床浅析

    Release date:2016-09-02 05:46 Export PDF Favorites Scan
  • The review and prospect of the decade of neuro-ophthalmology in China

    Neuro-ophthalmology is an interdisciplinary discipline that spans multiple disciplines such as ophthalmology, neurology, and neurosurgery, and plays an important role in ophthalmology. Since the establishment of the Neuro-Ophthalmology Group in 2011, it has shown a good momentum of accelerated development of neuroophthalmology team building, promoting the process of neuroophthalmology standardization and strengthening interdisciplinary cooperation. However, there is still a gap between the level of neuro-ophthalmology in China and that in developed countries, which still cannot get rid of the stage of introduction and imitation. It is still a long way to form neuro-ophthalmology with unique characteristics in China. In the future, we should carry out clinical research while advancing basic research work, and establish a standard training system to strengthen the training of neuroophthalmologists. It is expected that in the next 10 years, China's neuro-ophthalmic diagnosis and research level will be significantly improved, and a number of landmark academic achievements will be achieved, and a number of internationally and domestically renowned neuro-ophthalmologist will be trained to further enhance the international academic status of neuro-ophthalmic research in China.

    Release date:2020-05-19 02:20 Export PDF Favorites Scan
  • Bibliometric analysis on research of ischemic optic neuropathy from Pubmed database

    Objective To learn the hotspots of study in ischemic optic neuropathy (ION). Methods Literature on ION published in January 2000 to July 2012 was identified in Pubmed database. MeSH terms that frequently appeared were identified and co-word analysis was carried out by cluster analysis. Then a network was drawn using social network analysis. Results A total of 1045 papers were included. The United States, England, Germany, France and Netherlands together accounted for 71.53% (748) of the articles. There were 28 high-frequency MeSH terms and hot topics clustered into four fields. The appearance frequency of MeSH showed that most research focused on: (1)postoperative or arteritic ION; (2)epidemiology, pathology and diagnosis of ION; (3)pathophysiology and therapy of ION; (4) chemically induced ION. Conclusion The international main research focus of ION includes four fields, which may provide reference or scholars both in scientific research and clinical research.

    Release date:2016-09-02 05:22 Export PDF Favorites Scan
  • 首诊于眼科的Creutzfeld-Jakob病一例

    Release date:2016-09-02 05:52 Export PDF Favorites Scan
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