Objective To investigate the changes of multifocal electroretinogram (mf-ERG) in type 2 diabetes without clinically apparent retinopathy. Methods Eighteen type 2 diabetes patients (32 eyes) without clinically observed retinopathy and 14 normal control eyes received mfERG examination. Results The latency of P1 wave in the ring one, ring two and ring three of diabetes were (48.47±2.33), (31.19±15.53), (15.67±5.73) ms respectively, which had significantly statistical difference with the normal control eyes (t=5.145，2.376，2.276；P＜0.05). The amplitude density of P1 wave of temporal retina in diabetes patients was (9.07±2.19) nV/deg2,which was significant different （t=-3.468,P＜0.05） with the normal control eyes (14.13±2.76) nV/deg2. Conclusion The latency of mf-ERG P1 wave is delayed, and the amplitude density of P1 wave of temporal retina is declined in type 2 diabetes patients without clinically apparent retinopathy.